Diététique et lithiase rénale : le rôle de leau

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SITUATION EXTRÊME 1 : ABSENCE D’ADH
Liquide interstitiel
PLASMA
Absence ADH
CANAL COLLECTEUR
Récepteur V2
2
1
eau
Osm. urinaire (sortie
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= 60 – 100 mOsm/kg
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3
eau
Osm. urinaire = 60 – 100 mOsm/kg
Osm. plasmatique
Cortex rénal =
290 mOsm/kg
Médulla =
290 – 1200 mOsm/kg
Osm. inter.
Cortex rénal =
290 mOsm/kg
Médulla =
290 – 1200 mOsm/kg
4
1. Pas d’activation du récepteur V2
2. Imperméabilité de l’épithélium à l’eau
3. Pas de modification de l’osmolalité
urinaire
4. Débit urinaire élevé pour éliminer
toute la charge osmotique
Débit urinaire élevé = 9 – 15 l/jour*
SITUATION EXTRÊME 2 : STIMULATION MAXIMALE DES RÉCEPTEURS V2
Récepteur V2
Absence ADH
1
2
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290 mOsm/kg
Médulla =
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Osm. inter.
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Médulla =
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4
Débit urinaire moins élevé = 0,75 l/jour*
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3. Modification de l’osmolalité urinaire
en cohérence de l’osmolalité
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4. Débit urinaire moins élevé pour
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