human population genomics and genetic

Transcription

HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY
COURSE
(from 29th September to 10th October, 2014)
This two-week course presents theoretical lectures, research examples and hands-on computer
training on concepts and tools used in the study of human population genomics and genetic
epidemiology.
The first week consists in three days of both theoretical lectures and research examples, and two
days of hands-on-computer training and discussions presenting the concepts and the technical
tools used in both human population genomics and genetic epidemiology.
The second week consists in detailed theoretical bases in population genomics and genetic
epidemiology analyses and practical computer-based training in the most recent concepts and
analyses used in both disciplines.
The practical training (computer laboratory work and discussion of the results) is based on realdata examples, using as a paradigm infectious diseases.
Candidates must have basic knowledge in molecular genetics, statistics and informatics
Co-directors
Lluis QUINTANA-MURCI
Unit of Human Evolutionary Genetics
CNRS URA 3012
Institut Pasteur, Paris
Alexandre ALCAIS
Human Genetics of Infectious Diseases
INSERM /Univ. Paris Descartes - Unité 1163
Institut Imagine, Paris
Director of the Epidemiology and Public Health theme
Arnaud FONTANET
Emerging Diseases Epidemiology Unit
Institut Pasteur, Paris
FIRST WEEK
th
Monday, 29 September
9:00 - 10:30
Human Genome Diversity
Welcome and administrative matter
General Introduction
10:45 - 12:15
Registration office - Secretary to the course
Alexandre ALCAIS (Institut Imagine, Paris)
and Lluis QUINTANA-MURCI (Institut Pasteur, Paris)
Human genome diversity and public databases
Lluis. QUINTANA-MURCI
(Institut Pasteur, Paris)
13:30 - 15:30
Basics in bioinformatics
Guillaume LAVAL
15:30 - 17:30
Principles in population genetics
Paul VERDU
(Muséum National d’Histoires Naturelles, Paris)
th
Tuesday, 30 September
9:00 - 10:30
Basics Population Genetics and Genetic Epidemiology
Basics in statistical genetics
Alexandre ALCAIS
(Institut Imagine, Paris)
10:45 - 12:15
Principles in genetic epidemiology
Alexandre ALCAIS
13:30 - 15:00
Linkage disequilibrium: principles and methods
Etienne PATIN
15:30 - 17:00
Linkage disequilibrium: hands-on computer
Quentin VINCENT
and Alexandre ALCAIS
st
Wednesday, 1
9:00 - 10:30
October
Linkage analyses in humans
Research examples in genetic epidemiology: why and how
Alexandre ALCAIS
10:45 - 12:15
Linkage analyses: principles and methods
Sophie GARNIER
(Univ. Pierre & Marie Curie, Paris)
13:30 - 17:00
Linkage analyses: hands-on computer
Jean GASCHIGNARD
(Univ. Paris-Descartes, Paris)
and Audrey GRANT
nd
Thursday, 2
9:00 - 10:30
October
From association studies to human demography
Association studies: principles and methods
Audrey GRANT
10:45 - 12:15
Association studies: hands-on computer
Audrey GRANT
13:30 - 17:00
Population structure and human demography
Guillaume LAVAL
rd
Friday, 3 October
9:00 - 10:30
Natural selection in the human genome
Research examples in population genetics: why and how
10:45 - 12:15
Natural selection: principles and methods
Luis BARREIRO
(Univ. Montreal, Canada)
13:30 - 17:00
Natural selection: hands-on computer
Hélène QUACH
and Luis BARREIRO
****
SECOND WEEK
th
Monday, 6 October
9:00 - 11:00
Genome-wide scans for selection (GSS) and eQTLs
The genetics of gene expression: principles, methods and eQTLs
Luis BARREIRO
11:15 - 12:15
Basics in genome-wide statistics
Guillaume LAVAL
13:30 - 17:00
Genome-wide scans for selection: principles and hands-on computer Guillaume LAVAL
and Etienne PATIN
th
Genome-wide association studies (GWAS)
9:00 - 10:30
Genome-wide association studies: principles and methods
Tuesday, 7 October
Etienne PATIN
10:45 - 12:15
Genome-wide association studies: hands-on computer 1
Aurelie COBAT
and Jean GASCHIGNARD
13:30 - 15:00
Genome-wide association studies: hands-on computer 2
15:30 - 17:00
Genome-wide association studies: research examples
Aurelie COBAT
and Jean GASCHIGNARD
Anavaj SAKUNTABHAI
th
Wednesday, 8 October
9:00 - 10:30
DNA sequencing and beyond
Methylation in health and disease
Maud FAGNY
10:45 - 12:15
Whole exome sequencing and disease
Quentin VINCENT
13:30 - 15:00
Human genetics and microbiota
Laure SEGUREL
(Muséum National d’Histoires Naturelles, Paris)
15:30 - 17:00
The ENCODE project
Quentin VINCENT
th
Thursday, 9 October
9:00 - 12:15
Working together
Discussion of research: population genomics
and Hélène QUACH
13:30 - 17:00
th
Discussion of research: genetic epidemiology
Friday, 10 October
Alexandre ALCAIS
and Audrey GRANT
Keynote lectures
Both lectures will take place Room Jean-Paul Aubert (building Fernbach 68), on the ground floor
10:00 - 11:00
11:00 - 12:00
14:30 - 17:30
Human genetics of M. tuberculosis infection:
a new view of an old disease
Deconstructing aging-related cognitive decline: an
integrated “omics” approach to a clinical question using
prospective cohort studies
Written examination (Room 4 of the Teaching Centre)
Duration 3 hours - Grade out of 20
****
Erwin SCHURR
(McGill University, Canada)
Philip L. DE JAGER
(Harvard Medical School, USA)
HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY
COURSE
2014 - 2015
CO-DIRECTORS
Mr ALCAIS Alexandre
Human Genetics of Infectious Diseases,
INSERM /Université Paris Descartes - Unité 1163
Institut Imagine
24, boulevard du Montparnasse
75015 Paris
France

+33-(0)1 42 75 43 13
email : [email protected]
Mr QUINTANA-MURCI Lluis
Institut Pasteur
25/28, rue du Dr Roux
75724 Paris Cedex 15
France

+33-(0)1 40 61 34 43
LECTURERS
Mr BARREIRO Luis
CHU Sainte-Justine
University of Montreal
3175, Chemin de la Côte-Sainte-Catherine
Montreal (QC) H3T 1C5
Canada
Ms COBAT Aurélie
INSERM / Université Paris Descartes - Unité 1163
Institut Imagine
75015 Paris
France
email [email protected]
Mr DE JAGER Philip L.
Brigham & Women’s Hospital
Dept. Neurology
B. & W, Centr. Genetics and Genomics
Nrb 168
77 avenue Louis Pasteur
Boston, MA 02115
USA
email: [email protected]
Ms FAGNY Maud
Institut Pasteur
France
Ms GARNIER Sophie
Université Paris 6, Pierre & Marie Curie,
Faculté de Médecine Pitié-Salpêtrière
UMR ICAN 1166
91, boulevard de l'Hôpital
France
Mr GASCHIGNARD Jean
Human Genetics of Infectious Diseases,
INSERM U 980,
Université Paris-Descartes
96 rue Didot
France
Ms GRANT Audrey
Unité de Génétique Fonctionnelle des
Maladies Infectieuses
Institut Pasteur
France
Mr LAVAL Guillaume
Institut Pasteur
France
Mr PATIN Etienne
Institut Pasteur
France
Ms QUACH Hélène
Institut Pasteur
France
Mr SAKUNTABHAI Anavaj
Unité de Génétique Fonctionnelle des
Maladies Infectieuses
Institut Pasteur
France
Mr SCHURR Erwin
McGill University
Centre for the Study of Host Resistance
1650 Cedar Ave. - Room L11-520
Montreal (QC) H3G 1A4
Canada
Ms SEGUREL Laure
UMR 7206 Ecoanthropology
Muséum National d'Histoire Naturelle
57, rue Cuvier
CP 139
France
Mr VERDU Paul
UMR 7206 Ecoanthropology and Ethnobiology
Muséum National d'Histoire Naturelle
57, rue Cuvier
CP 139
France
Mr VINCENT Quentin
INSERM / Univ. Paris-Descartes / U1163
Institut Imagine
75015 Paris
France
_______________

human population genomics and genetic

Transcription

Documents pareils

human population genomics and genetic