human population genomics and genetic

Transcription

HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY
COURSE
(from October 3 to October 14, 2016)
This two-week course presents theoretical lectures, research examples and hands-on computer
training on concepts and tools used in the study of human population genomics and genetic
epidemiology.
The first week consists in three days of both theoretical lectures and research examples, and two
days of hands-on-computer training and discussions presenting the concepts and the technical
tools used in both human population genomics and genetic epidemiology.
The second week consists in detailed theoretical bases in population genomics and genetic
epidemiology analyses and practical computer-based training in the most recent concepts and
analyses used in both disciplines.
The practical training (computer laboratory work and discussion of the results) is based on realdata examples, using as a paradigm infectious diseases.
Candidates must have basic knowledge in molecular genetics, statistics and informatics
Co-directors
Lluis QUINTANA-MURCI
Unit of Human Evolutionary Genetics
CNRS URA 3012
Institut Pasteur, Paris
Alexandre ALCAIS
Human Genetics of Infectious Diseases
INSERM /Univ. Paris Descartes - Unité 1163
Institut Imagine, Paris
FIRST WEEK
Monday, 3 October
9:00 - 10:30
Human Genome Diversity
Registrar’s office
Welcome
General Introduction
10:45 - 12:15
Alexandre ALCAIS (Univ. Paris-Descartes, Paris)
and Lluis QUINTANA-MURCI (Institut Pasteur, Paris)
Human genome diversity and public databases
(Institut Pasteur, Paris)
13:30 - 15:00
Principles in genetic epidemiology
Alexandre ALCAIS
(Univ. Paris-Descartes, Paris)
15:30 - 17:00
Principles in population genetics
Paul VERDU
(Muséum National d’Histoire Naturelle, Paris)
Tuesday, 4 October
9:00 - 10:30
Basics Population Genetics and Genetic Epidemiology
A survival kit to bioinformatics
Guillaume LAVAL
10:45 - 12:15
A survival kit to statistical genetics
Alexandre ALCAIS
13:30 - 15:00
Linkage analyses: principles and methods
Sophie GARNIER
(Univ. Pierre & Marie Curie, Paris)
15:30 - 17:00
Research examples in genetic epidemiology: why and how
Alexandre ALCAIS
Wednesday, 5 October
9:00 - 12:15
Linkage analyses in humans
Linkage analyses: hands-on computer
Fabienne JABOT-HANIN and Aurélie COBAT
13:30 - 15:00
Linkage disequilibrium: principles and methods
Etienne PATIN
15:30 - 17:00
Linkage disequilibrium: hands-on computer
Alexandre ALCAIS
Thursday, 6 October
9:00 - 10:30
From association studies to human demography and selection
Association studies: principles and methods
Alexandre ALCAIS
10:45 - 12:15
Association studies: hands-on computer
Aurélie COBAT
13:30 - 15:30
Population structure and human demography
Guillaume LAVAL
16:00 - 17:00
Genome diversity and natural selection: research example
Friday, 7 October
9:00 - 10:30
Natural selection in the human genome
Genetics of social networks in non-human primates: research example Luis BARREIRO
(Univ. Montreal, Montreal)
10:45 - 12:15
Natural selection: principles and methods
Luis BARREIRO
(Univ. Montreal, Montreal)
13:30 - 17:00
Natural selection: hands-on computer
******************
Hélène QUACH (Institut Pasteur, Paris)
and Luis BARREIRO (Univ. Montreal, Montreal)
SECOND WEEK
Monday, 10 October
9:00 - 12:15
Working together
Discussion of research: genetic epidemiology
Alexandre ALCAIS
and GenEpiTeam
13:30 - 17:00
Discussion of research: population genomics
and Hélène QUACH
Tuesday, 11 October
9:00 - 10:30
Genome-wide association studies (GWAS)
Genome-wide association studies: principles and methods
Etienne PATIN
10:45 - 12:15
Genome-wide association studies 1: hands-on computer
Aurélie COBAT
and Gaspar KERNER
13:30 - 15:00
Genome-wide association studies 2: hands-on computer
Aurélie COBAT
and Gaspar KERNER
15:30 - 17:00
Genome-wide association studies: research examples
Anavaj SAKUNTABHAI
Wednesday, 12 October
9:00 - 10:30
Genome-wide scans for selection (GSS)
Basics in genome-wide statistics
Guillaume LAVAL
10:45 - 11:30
Purifying selection and burden of deleterious mutations
Marie LOPEZ
11:15 - 12:15
Balancing selection and advantageous mutations
Joao TEIXEIRA
13:30 - 17:00
Genome-wide scans for selection: principles and
hands-on computer
Guillaume LAVAL
and Etienne PATIN
Thursday, 13 October
9:00 - 10:30
DNA sequencing and beyond
Human genetics of infectious diseases
Laurent ABEL
10:45 - 12:15
Genetics of gene expression: principles, methods and eQTLs
Maxime ROTIVAL
13:30 - 15:00
DNA Methylation in health and disease
Lucas HUSQUIN
15:30 - 17:00
Whole exomes/genomes sequencing in common diseases
Aurélie COBAT
Friday, 14 October
Keynote lectures
Both lectures will take place Room Jules Bordet, Building Metchnikoff (67), on the ground floor
10:00 - 11:00
11:00 - 12:00
The dark side of human expansions: a burden of
deleterious mutations
Single cell genetics and complex pathways
Laurent EXCOFFIER
(University of Bern, Switzerland)
Antonio RAUSELL
(Imagine Institute, Paris)
14:30 - 17:30
Written examination (Room 4 of the Teaching Centre)
Duration 3 hours - Grade out of 20
HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY
COURSE
2016 - 2017
CO-DIRECTORS
Mr ALCAIS Alexandre
Human Genetics of Infectious Diseases,
INSERM / Université Paris Descartes - Unité 1163
Institut Imagine
24, boulevard du Montparnasse
75015 Paris
France
Phone +33-(0)1 42 75 43 13
Email [email protected]
Mr QUINTANA-MURCI Lluis
Unit of Human Evolutionary Genetics
CNRS URA 3012
Institut Pasteur
25/28, rue du Dr Roux
75724 Paris Cedex 15
France
Phone +33-(0)1 40 61 34 43
Email [email protected]
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human population genomics and genetic

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human population genomics and genetic