excel motors

EMILIE BERTRAND
14, bd du Général de Gaulle 91210 Draveil France
Born on the 6th of February 1983
In France
: (+33).9.51.63.96.65
: (+33).6.81.32.34.52
Email: [email protected]
2008 - 2012
2007
2004 - 2006
2012
(7 months)
2008-2012
2007
(7 months)
2006
(1 month)
2005
(1 month)
EDUCATION
Doctorat in Chemistry and Physical Chemistry of Polymer
« Laboratoire d'Analyse et de Modélisation pour la Biologie et L'Environnement », University of Evry,
France
Master « Science, Technologie, Santé, Mention Molécules et Matériaux, Spécialité Polymères
Fonctionnels »
University Paris XII, Créteil, France
Bachelor of Science in Biological & Biochemical Engineering
University Paris XII, Créteil, France
WORK EXPERIENCE
Post-doctorat in Polymer Chemistry, supervisor : Pr P. Guégan
Modification of cyclodextrin by click chemistry to obtain a ligand for cell target
Characterisation of complexes between cyclodextrin and polymers by ITC, Laboratoire d'Analyse et de
Modélisation pour la Biologie et L'Environnement, University of Evry, France
Doctorat in Chemistry and Physical Chemistry of Polymer, supervisor : Pr P. Guégan
Synthesis and characterization of new polymers based on linear poly(ethylenimine), as non toxic and
efficient vectors for gene therapy, LAMBE, University of Evry, France
Internship position, Elaboration of products for medical imaging: synthesis and physico-chemical
study of emulsions and liposomes
Pharmaceutical group GUERBET, Aulnay-sous-Bois, France
Laboratory technician, Blood analysis: histological tests, cell culture
« Laboratoire d’Analyse Medicale », Choisy-Le-Roi, France
Internship, Regioselective sulfation of glucose unprotected assisted imprinted polymers
« Laboratoire de Croissance, Réparation et Régénération Tissulaires », Créteil, France
2008 - 2011
-
TEACHING EXPERIENCE
Monitorat and semi-ATER
- TD and TP of Organic chemistry, Water solution chemistry (pH, conductimetry, electrochemistry...),
Thermodynamic (kinétic, calorimetry), Polymers (formulation, mechanical properties, polymers in
solution, macromolecular synthesis,) : first grade of licence at first grade of master, University of Evry,
France
- Popularisation of science during the one week Science Festival, for secondary school pupil,
University of Evry, Evry, France
EXPERTISES
Organic synthesis : modification of polymer (Mickael addition), modification of olygo-saccharide ( and
cyclodextrin by “Click chemistry”), modification of glucose (déméthylation, thyosylation, sulfatation)
Analysis techniques : Chromatography, Nuclear Magnetic Resonance, Mass spectrometry (ESI-MS, MALDI-TOF),
DSC, zeta potential, tonometry
Formulation : Nanoparticules Polymer/DNA complexation, Liposomes and Emulsions by extruder and microfluidizer.
Microbiological compound identification and purification : PCR, Western Blot, gel electrophoresis, histological
tests, cell culture
Logiels : Chemdraw, Isisdraw, Endnote, Topsin, Word, Excel, Powerpoint, Origin, motors of research : Titanescience,
Google Scholar, Science Direct
English
2008 - 2010
2008 - 2011
2008
ADMINISTRATIVE TASKS
Member of Scientific Research Council, Université d’Evry, France
Member of PhD school Council in Science and Engineering, Université d’Evry
First aid training
PUBLICATIONS
- Histidinylated linear PEI: a new efficient non toxic polymer for gene therapy. E. Bertrand, H. Cheradame, P. Midoux, P.
Guégan et al. ChemCom., 2011, 47 (46) 12547-49.
- Gene transfer by chemical vectors: A comparative study of the uptake routes of polyplexes, lipoplexes and lipopolyplexes
in a myoblast cells line. L. Billet, E. Bertrand, H. Cheradame, P. Guégan, B. Pitard, P. Lehn, P. Midoux. et al., 2012,
33(10),2980-90.
- Synthesis, Physicochemical and biological Characterization of Polyethylenimine grafted Histidine derivative; a New
Biomaterial for Gene Therapy. Y. El Ghoul, E. Bertrand, H. Cheradame, P. Lehn, T. Montier and P. Guégan et al. (in
preparation)
CONFERENCE PARTICIPATIONS
- Transendothelial passage of polyplexes across a pulmonary vascular endothelium, JP. Gomez, E. Bertrand, P. Guegan, P.
Midoux et al. (Poster), 10th Annual Congress of the French-Society-of-Cell-and-Gene-Therapy (SFTCG), Juin 2011
(Nantes, France)
- New polymer-based nonviral carrier for gene delivery, El Ghoul Y., Bertrand E., Midoux P., Cheradame H., Montier T.,
Guégan P. et al. (Poster), 12ème colloque “des Jeunes Chercheurs” (VLM), March 2011(Pasteur - Paris-France)
- Etude du passage transendothélial des polyplexes histidinylés à travers l’endothélium vasculaire pulmonaire - Gomez J.-P.,
E. Bertrand, P.A. Jaffres, H. Cheradame, P. Guégan, P. Midoux., et al. (Poster), 12 ème colloque “des Jeunes Chercheurs”
(VLM), March 2011 (Brest - France)
- Synthèse de nouveaux vecteurs, la lPEI histidinylée : étude de son efficacité in vitro pour la thérapie génique - E. Bertrand,
P. Lehn, H. Cheradame, P. Midoux , P. Guégan et al. (Oral), 3ème colloque “Polymères” (POL-IdF), September 2010
(Cergy - France)
- Histidinylated lPEIs as new DNA carriers for in vitro and in vivo gene transfer with low toxicity - P. Guégan, E. Bertrand,
T. Legall, C. Pichon, T. Montier, P. Lehn, H. Cheradame, P. Midoux (Oral) 32 th european conference on mucoviscidose
June 2009 (Brest - France)
- Histidinylated linear PEIs as new DNA carriers for in vitro and in vivo gene transfer with low toxicity, E. Bertrand, T.
Legall, C. Pichon, T. Montier, P. Lehn, H. Cheradame, P. Midoux, P. Guegan (Poster) 32 th european conference on
mucoviscidose June 2009 (France)
- Histidinylated lPEI as new DNA carrier for in vitro and in vivo Gene Transfer with Low Toxicity, P. Guegan, E. Bertrand,
P. Lehn, H. Cheradame, P. Midoux et al. (Poster) 32 th european conference on mucoviscidose June 2009 (Brest - France)
PROCEEDING
- Transendothelial passage of polyplexes across a pulmonary vascular endothelium, JP. Gomez, E. Bertrand, P. Guegan, P.
Midoux et al. Human gene Therapy, 2011, 22 (6), A19-A20.
- Histidinylated lPEI as new DNA carrier for in vitro and in vivo Gene Transfer with Low Toxicity, P. Guegan, E. Bertrand,
P. Lehn H., Cheradame H, P. Midoux et al. Journal of Cystic Fibrosis. 2009, 8(2), S30.2
COLLABORATION
- Centre de biophysique moléculaire, Université d’Orléans, France.
Formulation and transfection in vitro of vector/DNA
- Génétique moléculaire et génétique épidémiologique, Université de Brest Occidentale, Brest, France
Transfection in vivo of vector/DNA
- Laboratoire Polymères, Biopolymères, Surfaces, Université de Rouen, Rouen, France
Determination of molar mass by SEC/MALLS
FINANCIAL SUPPORTS
French Government scholarship for PhD
CENTER OF INTEREST
Collection of minerals, puzzle, Echecs, Tarot, Sudoku, Natation
REFERENCES
Philippe GUEGAN :
[email protected]
Hervé CHERADAME : [email protected]
Patrick MIDOUX :
[email protected]