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t p< Accumbens 7.20 10-10 Amygdala 8.32 10-13 BrainStem 3.79 .001 Caudate 5.88 10-7 Cerebellum GM 7.18 10-10 Cerebellum WM 3.51 .001 Cerebral WM 8.00 10-13 Hippocampus 12.80 10-26 Pallidum 4.77 10-5 Putamen 7.85 10-12 Thalamus 6.59 10-9 Lat vent -7.61 10-11 Inf lat vent -9.74 10-17 3rd ventricle -5.50 10-6 4th ventricle -1.79 n.s. Cingulate, caudal ant 6.22 10-8 Cingulate, rostral ant 6.37 10-8 Cingulate, posterior 8.76 10-14 Cingulate, isthmus 10.19 10-18 Volumetric ROIs Ventricular ROIs Surface ROIs Frontal, superior 5.98 10-7 Frontal, caudal middle 7.71 10-12 Frontal, rostral middle 6.07 10-8 Frontal, pars opercularis 6.69 10-9 Frontal, pars triangularis 5.86 10-7 Frontal, pars orbitalis 4.07 10-4 Frontal, lateral orbital 6.58 10-9 Frontal, medial orbital 5.78 10-7 Frontal, pole 3.50 .001 Parietal, precentral gyrus 5.13 10-6 Parietal, post central gyrus 3.52 .001 Parietal, paracentral gyrus 4.94 10-5 Parietal, superior 7.86 10-12 Parietal, inferior 10.74 10-19 Parietal, supramarginal 8.25 10-13 Parietal, precuneus 9.89 10-17 Temporal, parahippocampal 12.69 10-26 Temporal, entorhinal 11.93 10-25 Temporal, pole 9.36 10-16 Temporal, superior 8.34 10-13 Temporal, middle 12.81 10-25 Temporal, inferior 13.25 10-26 2.16 n.s. Temporal, Banks Sup Temp Sulc 10.97 10-20 Temporal, fusiform 13.15 10-26 Temporal, transverse Occipital, lateral 7.64 10-12 Occipital, pericalcarine 2.87 .01 Occipital, lingual 7.60 10-12 Occipital, cuneus 5.20 10-6 Supplementary Table 1 Test of differences in 1 year rate of atrophy between healthy controls and Alzheimer patients n.s. indicates p > .01