Document 1. Supplemental table and appendix

Document 1. Supplemental table and appendix

Supplement Table 1
n
CIR
(%+/- SE)
NRM
(%+/- SE)
acute GVHD
grade II-IV
(%+/- SE)
chronic
GVHD
(%+/- SE)
OS
(%+/- SE)
LFS
(%+/- SE)
NPM1wt / Flt3wt
290
14+/-2%
16+/-2%
31+/-3%
44+/-3%
75+/-3%
70+/-3%
NPM1mut/ Flt3wt
68
16+/-5%
10+/-4%
17+/-5%
43+/-7%
81+/-5%
75+/-5%
NPM1wt / Flt3-ITD
75
34+/-6%
17+/-5%
35+/-6%
31+/-6%
54+/-7%
48+/-7%
NPM1mut/ Flt3-ITD
269
26+/-3%
13+/-2%
29+/-3%
38+/-3%
66+/-3%
60+/-7%
0.0009
0,75
0,23
0,27
0,003
0.002
global P value
Influence of molecular subgroups on outcome at two years after allogeneic
HSCT (univariate analysis)
Abbreviations: CIR, cumulative incidence of relapse;
NRM, non-relapse mortality; GvHD, graft-versus-host disease; SE, standard error;
OS, overall survival; LFS, leukemia-free survival
Appendix: Participating centers
Patients were reported from the following EBMT transplant centers, whose contribution
to this analysis is highly appreciated (numbers indicate EBMT center identification
code):
207 Paris [St Louis], 233 Besancon [H Jean Minjoz], 515 Helsinki [Univ Central H], 624
Toulouse [H Purpan], 666 Villejuif [Gustave Roussy], 267 Pessac [H Haut-Leveque],
246 Rotterdam [Erasmus ` den Hoed] 253 Nantes [Hotel Dieu] 209 Leuven [Univ H] 718
Pilsen [Charles Univ H] 230 Marseille [Paoli Calmettes], 283 Lund [Univ H],650 Angers
[CHRU], 212 Stockholm [Univ H],235 Oslo [Rikshospitalet], 672 Strasbourg [H
Hautepierre], 676 Vandoeuvre_Les_Nancy [H d`Enfants,926 Montpellier [University],
202 Basel, 206 Copenhagen [Rigshospitalet], 658 Bergamo [Ospedale, ematol], 671
Lyon [H E Herriot], 311 Wiesbaden [Kl Diagnostik], 152 Augsburg [Zentra Kl], 203
Leiden [Univ H], 250 Saint_Etienne [St Etienne], 556 Budapest [National Med Ctr], 613
Barcelona [H Trias i Pujol], 225 Turku [University], 262 Paris [Pitie-Salpetrriere], 546
Groningen [Univ H], 565 Maastricht [Univ H],, 810 Freiburg [University], 289 Goeteborg
[Sahlgrenska Univ H], 775 Paris [St Antoine], 277 Lille [H Claude Huriez], 544 Monza
[Osp S Gerardo] 941 Rouen [Becquerel] , 251 Caen [Hopital, Hematol], 257 Dublin [St
James], 270 Grenoble [H A Michallon], 659 Brest [H Agustin-Morvan], 661 Rennes [H
Sud/Pontchaillou], 665 Clamart [H Percy], 726 Liege [University], 237 Nijmegen [St
Radboud], 242 Santander [Valdecilla], 252 Creteil [H Mondor Hematol], 273 ClermontFerrand [Jean Perrin], 756 Rome [Tor Vergata], 231 Torino [S. Giovanni (CTO)], 387
Birmingham [Queen Elizabeth] , 977 Limoges [CHRU], 208 Zürich [208], 215 Brussels
[Jules Bordet], 234 Brussels [St. Luc], 259 Essen [Univ H], 260 Barcelona [SCreu i S
Pau], 304 Firenze [Careggi-Meyer],642 Oviedo [H Covadonga], 731 Umeå [Univ H], 204
Ulm [Medizin Kl / Polikl], 232 Rome [Emat, `La Sapienza`], 264 Poitiers [H La
Miletrie],281 Patras [Univ H], 290 Karlsruhe [Klinikum]´, 588 Amsterdam [VU Univ Med
Ctr], 598 San_Sebastian [H Aranzazu], 614 Hamburg [Univ H], 623 Verona [Policlinico],
625 Nürnberg [Klinikum], 717 Nottingham [City H], 727 Salamanca [H Clinico], 744
Gent [Univ H], 785 Homburg [Univ Saarland], 161 Tel_Aviv [Sourasky] , 216 London
[Royal Free], 224 London [UCL], 255 Oxford [Radcliffe H], 268 Belfast [City H], 523 Nice
[H de l`ARCHET I], 561 Thessaloniki [G Papanicolaou G H], 602 Bremen [Kl BremenMitte], 740 Linköping [Univ H] , 778 Sheffield [Royal Hallamshire], 955 Amiens [H Sud],
994 Istanbul [Nightingale], 996 Antwerp_Edegem [UZA]