Télécharger la liste des 67 posters
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Télécharger la liste des 67 posters
Participation IUCT Oncopole - CRCT 67 posters dont 3 communications orales et 9 posters 1er auteur Communications orales 1142 Frontline Therapy with Carfilzomib, Lenalidomide, and Dexamethasone (KRd) Induction Followed By Autologous Stem Cell Transplantation, Krd Consolidation and Lenalidomide Maintenance in Newly Diagnosed Multiple Myeloma (NDMM) Patients: Primary Results of the Intergroupe Francophone Du MyéLome (IFM) Krd Phase II Study Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 653. Myeloma: Therapy, excluding Transplantation: IMiD/Proteasome Inhibitor Combinations and Maintenance Therapy 1* 2* 3* 4* Murielle Roussel, MD , Valerie Lauwers-Cances, MD , Nelly Robillard, PhD , Karim Belhadj, MD , Thierry 5 6 7* 8* Facon, MD, PhD , Laurent Garderet, MD , Martine Escoffre, MD , Brigitte Pegourie, MD , Lotfi Benboubker, 9* 10* 11* 12* 13 14* MD, PhD , Denis Caillot , Cecile Fohrer, MD , Philippe Moreau , Xavier Leleu , Hervé Avet-Loiseau and 15 Michel Attal 1 Institut Universitaire du Cancer, toulouse, France 2 USMR, service d'Epidemiologie, CHU Toulouse, TOULOUSE, France 3 Hematology Laboratory, Nantes University Hospital, Nantes, France 4 CHU Henri Mondor, Creteil, France 5 Maladies du Sang, Lille University Hospital, Lille, France 6 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 7 CHU Rennes, Rennes, France 8 Hôpital A.Michallon, CHU Grenoble, Grenoble, France 9 Hôpital Bretonneau Service Hématologie et Thérapies Cellulaires, Centre Régional de Cancérologie Henry Kaplan CHRU de Tours, Tours, France 10 Hématologie Clinique, Dijon University Hospital, Dijon, France 11 HEMATOLOGY, CHU, Strasbourg, FRA 12 Department of Hematology, Nantes University Hospital, Nantes, France 13 ONCOLOGIE HEMATOLOGIQUE ET THERAPIE CELLULAIRE, CHU DE POITIERS, POITIERS, France 14 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 15 Institut Universitaire du Cancer-Oncopole, Toulouse, France 762 The Upper Age Limit for a Pediatric-Inspired Therapy in Younger Adults with Ph-Negative Acute Lymphoblastic Leukemia (ALL)? Analysis of the Graall-2005 Study Acute Lymphoblastic Leukemia: Clinical Studies Program: Oral and Poster Abstracts Type: Oral Session: 612. Acute Lymphoblastic Leukemia: Clinical Studies: New Approaches to Treatment Stratification and MRD Utilization 1* 2* 3 4 Françoise Huguet, MD , Thibaut Leguay , Xavier Thomas, MD, PhD , Nicolas Boissel, MD, PhD , Martine 5* 6* 7* 8 Escoffre-Barbe, MD , Patrice Chevallier, MD, PhD , Mathilde Hunault, MD, PhD , Norbert Vey, MD , Caroline 9* 10* 11 12,13 Bonmati, MD , Stéphane Leprêtre, MD , Jean-Pierre Marolleau, MD, PhD , Thomas Pabst, MD, PhD , 14* 15* 16 17* Philippe Rousselot, MD, PhD , Agnès Buzyn, MD, PhD , Jean-Yves Cahn, MD , Véronique Lhéritier , Marie C 18* 19* 20* Béné, PharmD, PhD , Vahid Asnafi, MD, PhD , Eric Delabesse, PharmD, PhD , Elizabeth Macintyre, MD, 21 13,22 23 24* PhD , Yves Chalandon, MD , Norbert Ifrah and Hervé Dombret, MD 1 Department of Hematology, Institut Universitaire de Cancérologie de Toulouse, Toulouse, France 2 Hematology, Bordeaux University Hospital, Pessac, France 3 Departement of Hematology, Centre Hospitalier Lyon Sud, HCL, Pierre Bénite, France 4 Hématologie Adulte, Saint-Louis Hospital, APHP, Paris, France 5 Departement of Hematology, CHU Rennes, Rennes, France 6 Department of Hematology, CHU, Nantes, France 7 Hematology, Medical University Hospital, Angers, France 8 Department of Hematology, Institut Paoli Calmettes, Marseille, France 9 Department of Hematology, Hôpitaux de Brabois, Vandoeuvre Lès Nancy, France 10 Department of Hematology, CLCC H Becquerel, Rouen, France Department of Hematology, CHU, Amiens, France 12 Department of Hematology, Bern University Hospital, Bern, Switzerland 13 Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland 14 Department of Hematology, Hôpital André Mignot, Versailles, France 15 Departement of Hematology, Hôpital Saint Antoine, AP-HP, Paris, France 16 Hematology, CHU Grenoble Alpes, Grenoble, France 17 GRAALL Coordination, Lyon-Sud University Hospital, Pierre-Bénite, France 18 Departement of Immunology, CHU, Nantes, France 19 Laboratory of Onco-Hematology, Hôpital Necker Enfants-Malades, APHP, Paris, France 20 Laboratory of Hematology, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 21 Laboratory of Onco-Hematology, Hôpital Necker Enfants-Malades, AP-HP, Paris, France 22 Division of Hematology, Geneva University Hospitals, Geneva, Switzerland 23 Departement of Hematologie, CHU, Angers, France 24 Departement of Hematology, Hôpital Saint-Louis, AP-HP, Paris, France 11 246 Evaluation of Minimal Residual Disease (MRD) in Relapsed/Refractory Multiple Myeloma (RRMM) Patients Treated with Daratumumab in Combination with Lenalidomide Plus Dexamethasone or Bortezomib Plus Dexamethasone Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Clinical Studies, Minimal Residual Disease, and Biomarkers 1* 2* 3* 4 5 Hervé Avet-Loiseau , Tineke Casneuf , Christopher Chiu, PhD , Jacob P. Laubach, MD , Je-Jung Lee , Philippe 6* 7 8* 9* 10* 11* Moreau , Torben Plesner, Professor , Hareth Nahi , Nushmia Z Khokhar , Ming Qi , Jordan Schecter , 12* 9* 11* 13 14 Victoria Carlton, Ph.D. , Xiang Qin , Kevin Liu , Kaida Wu, MD, PhD , Sen H. Zhuang, M.D., Ph.D. , 9* 9* 15 Tahamtan Ahmadi, MD , A. Kate Sasser, PhD and Jesús F. San-Miguel 1 Centre Hospitalier Universitaire Rangueil, Unité de Genomique du Myelome, Toulouse, France 2 Oncology Heme Translational Research Group, Janssen Research & Development, Beerse, Belgium 3 Oncology Heme Translational Research Group, Janssen Research & Development, LLC, Spring House, PA 4 Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 5 Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Jeollanamdo, Korea, The Republic of 6 Department of Hematology, Nantes University Hospital, Nantes, France 7 Department of Hematology, Vejle Hospital and University of Southern Denmark, Vejle, Denmark 8 Center for Hematology and Regenerative Medicine, Karolinska Institutet, Stockholm, Sweden 9 Janssen Research & Development, LLC, Spring House, PA 10 Janssen Research & Development, Spring House, PA 11 Janssen Research & Development, LLC, Raritan, NJ 12 Adaptive Biotechnologies Corp, South San Francisco, CA 13 Janssen Oncology, Springhouse, PA 14 Johnson & Johnson Pharmaceutical Research & Development, Raritan, NJ 15 Clínica Universidad de Navarra-CIMA, IDISNA, Pamplona, Spain Posters 674 Ixazomib-Lenalidomide-Dexamethasone (IRd) Combination before and after Autologous Stem Cell Transplantation (ASCT) Followed By Ixazomib Maintenance in Patients with Newly Diagnosed Multiple Myeloma (NDMM): A Phase 2 Study from the Intergroupe Francophone Du MyéLome (IFM) Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Type: Oral Session: 731. Clinical Autologous Transplantation: Results: Clinical Autologous Transplantation in Myeloma I 1* 2* 3* 4* 5* Philippe Moreau, MD , Cyrille Hulin, MD , Denis Caillot , Gerald Marit, MD , Aurore Perrot, MD , Laurent 6 7 8* 9* 10* Garderet, MD , Thierry Facon , Lotfi Benboubker, MD, PhD , Lionel Karlin, MD , Mourad Tiab , Bertrand 11* 12 13 14* 15* Arnulf, MD , Jean-Paul Fermand , Xavier Leleu , Cyrille Touzeau, MD , Murielle Roussel, MD , Lucie 16* 17* 18* 15* Planche , Stephane Minvielle , Marie-Christine Bene, PharmD , Hervé Avet-Loiseau , Thomas Dejoie, 19* 20 PharmD and Michel Attal 1 hematology department, university hospital, nantes, France 2 hematology department, university hospital, bordeaux, France 3 Hématologie Clinique, Dijon University Hospital, Dijon, France 4 hematology department, university hospital, Bordeaux, France 5 hematology department, university hospital, Vandoeuvre Les Nancy, France 6 Hematology Department, CHU St Antoine, Paris, France 7 Hematology, CHRU Lille Hôpital Claude Huriez, Lille, Lille, France 8 CHU Tours Hopital Bretonneau, Tours, France 9 hematology department, Hospices Civils de Lyon, PIERRE BENITE CEDEX, FRA 10 University Hospital, La Roche Sur Yon, France 11 hematology department, Hôpital Saint Louis, Paris, France 12 Hopital Saint-Louis, Paris, France 13 CHU DE POITIERS, POITIERS, France 14 Department of hematology, Nantes university Hospital and UMR892 INSERM, Nantes, France 15 hematology department, university hospital, toulouse, France 16 university hospital, nantes, France 17 Centre Hospitalier Universitaire de Nantes, Unité Mixte de Genomique du Cancer, Nantes, France 18 Hopital Hotel Dieu, Laboratoire d'Hematologie, Nantes, France 19 Biochemistry Laboratory, Centre Hospitalier Universitaire-Nantes, Nantes, France 20 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 1636 Dexamethasone Reduces Incidence of Relapse and Improves Overall Survival in Hyperleucocytic Acute Myeloid Leukemia Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 615. Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation: Poster I 1,2 1* 3* 4,5* Christian Récher, MD-Ph.D. , Sarah Bertoli, M.D; Ph.D , Muriel Picard, M.D , Emilie Bérard, M.D; Ph.D , 2* 1* 6* 7* 8* Clément Larrue, PhD , Suzanne Tavitian, M.D , Francois Vergez, DVM, Ph.D , Edwige Yon , Jean Ruiz, M.D , 9,10* 6* 11* 12 Eric Delabesse, PharmD, PhD , Isabelle Luquet, M.D , Laetitia Linares, PhD , Martin Carroll, MD , Audrey 13* 13* 2* Sarry , Françoise Huguet, M.D and Jean-Emmanuel Sarry, PhD 1 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 3 Service de Réanimation, CHU de Toulouse, Toulouse, France 4 Service d'Epidémiologie,, CHU de Toulouse, Toulouse, France 5 UMR 1027, INSERM-Université de Toulouse III, Toulouse, France 6 Laboratoire d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 7 Service d'Epidémiologie, CHU de Toulouse, Toulouse, France Service de Réanimation médicale, CHU de Toulouse, Toulouse, France 9 Laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France 10 Laboratory of Hematology, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 11 Institut de Recherche en Cancérologie de Montpellier, INSERM, U1194, Montpellier, France 12 Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA 13 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 8 3736 Interest in Initiating Corticosteroids By Intravenous Methylprednisolone at Standard Dose in Newly Diagnosed Immune Thrombocytopenia Adults: Results of the Prospective Carmen Registry Disorders of Platelet Number or Function Program: Oral and Poster Abstracts Session: 311. Disorders of Platelet Number or Function: Poster III 1* 2* 1* 3* 4* Anaïs Essilini , Thibault Comont , Johanne Germain, PhD , Natacha Brun, MD , Claire Dingremont, MD , 5* 6* 7* 8* Brice Castel, MD , Philippe Montané de la Roque, MD , Serge Madaule, MD , Laurent Sailler, MD, PhD , 9* 10* 11* 12* Laurent Prudhomme, MD , Sophie Arista, MD , Laurent Balardy, MD , Francis Gaches, MD , Benjamin 13* 14,15* 16* 17* Hebraud , Cecile Borel, MD , Stéphane Sire, MD , Miguel Carreiro, MD , Guillaume Martin-Blondel, MD, 11* 11* 18* 19* PhD , Laurent Alric, MD, PhD , Patrick Giraud, MD , Maryse Lapeyre-Mestre, MD, PhD , Odile Beyne20* 21* 22* Rauzy, MD, PhD , Daniel Adoue, MD, PhD and Guillaume Moulis, MD, PhD 1 UMR 1027 INSERM-University of Toulouse, Toulouse, France 2 Department of Internal Medicine, Toulouse University Hospital, Toulouse, France 3 Rodez Hospital, Rodez, France 4 Tarbes Hospital, Tarbes, France 5 Lourdes Hospital, Lourdes, France 6 Pamiers Hospital, Pamiers, France 7 Albi Hospital, Albi, France 8 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-University of Toulouse, Toulouse, France 9 Castres hospital, Castres, France 10 Auch hospital, Auch, France 11 Toulouse University Hospital, Toulouse, France 12 Ducuing hospital, Toulouse, France 13 Hématologie, CHU Toulouse, Toulouse, France 14 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse - CHU de Toulouse, Toulouse, France 15 IUCT-Oncopole, Toulouse, France 16 Cahors Hospital, Cahors, France 17 Montauban Hospital, Montauban, France 18 Pont de Chaume hospital, Montauban, France 19 Service de Pharmacologie Médicale et Clinique, INSERM U 1027, Toulouse, France 20 Service de medecine Interne, CHU Purpan, Toulouse, France 21 Service de Médecine Interne, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 22 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France Introduction. 3996 Survival Improvement for Acute Myeloid Leukemia Patients Treated in Routine Practice By Intensive Chemotherapy Between 2000 and 2014 Acute Myeloid Leukemia: Clinical Studies Program: Oral and Poster Abstracts Session: 613. Acute Myeloid Leukemia: Clinical Studies: Poster III 1* 2,3* 1* 4* Sarah Bertoli, M.D; Ph.D , Emilie Bérard, M.D; Ph.D , Suzanne Tavitian, M.D , Anne Huynh, MD , Cecile 5* 1* 6* 7* 4* Borel, MD , Sarah Guenounou , Isabelle Luquet, M.D , Eric Delabesse, PharmD, PhD , Audrey Sarry , Guy 1 8 4* 1,9 Laurent, M.D; Ph.D , Michel Attal , Françoise Huguet, M.D and Christian Récher, MD-Ph.D. 1 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Service d'Epidémiologie,, CHU de Toulouse, Toulouse, France 3 UMR 1027, INSERM-Université de Toulouse III, Toulouse, France Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 5 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse - CHU de Toulouse, Toulouse, France 6 Laboratoire d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 7 Laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France 8 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 9 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 4 1367 Positivity Rates of Tests Used at Immune Thrombocytopenia Diagnosis to Detect Associated Diseases. a Prospective Multicenter Cohort Study of 218 Patients Disorders of Platelet Number or Function Program: Oral and Poster Abstracts Session: 311. Disorders of Platelet Number or Function: Poster I 1* 2* 3* 3* Guillaume Moulis, MD, PhD , Thibault Comont , Johanne Germain, PhD , Anaïs Essilini , Natacha Brun, 4* 5* 6* 7* 8* MD , Claire Dingremont, MD , Brice Castel, MD , Philippe Montané de la Roque, MD , Serge Madaule, MD , 9* 10* 11* 12* Laurent Sailler, MD, PhD , Laurent Prudhomme, MD , Sophie Arista, MD , Laurent Balardy, MD , Francis 13* 14* 15* 16* 17* Gaches, MD , Benjamin Hebraud , Cecile Borel, MD , Stéphane Sire, MD , Miguel Carreiro, MD , 12* 12* 18* Guillaume Martin-Blondel, MD, PhD , Laurent Alric, MD, PhD , Patrick Giraud, MD , Maryse Lapeyre19* 20* 21* Mestre, MD, PhD , Odile Beyne-Rauzy, MD, PhD and Daniel Adoue, MD, PhD 1 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France 2 Department of Internal Medicine, Toulouse University Hospital, Toulouse, France 3 UMR 1027 INSERM-University of Toulouse, Toulouse, France 4 Rodez hospital, Rodez, France 5 Tarbes Hospital, Tarbes, France 6 Lourdes Hospital, Lourdes, France 7 Pamiers Hospital, Pamiers, France 8 Albi Hospital, Albi, France 9 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-University of Toulouse, Toulouse, France 10 Castres hospital, Castres, France 11 Auch hospital, Auch, France 12 Toulouse University Hospital, Toulouse, France 13 Ducuing hospital, Toulouse, France 14 Hématologie, CHU Toulouse, Toulouse, France 15 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse - CHU de Toulouse, Toulouse, France 16 Cahors Hospital, Cahors, France 17 Montauban Hospital, Montauban, France 18 Pont de Chaume hospital, Montauban, France 19 Service de Pharmacologie Médicale et Clinique, INSERM U 1027, Toulouse, France 20 Service de medecine Interne, CHU Purpan, Toulouse, France 21 Service de Médecine Interne, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 3991 Is Intermediate-Dose Cytarabine a Good Control for Patients with Relapsed or Refractory Acute Myeloid Leukemia? Acute Myeloid Leukemia: Clinical Studies Program: Oral and Poster Abstracts Session: 613. Acute Myeloid Leukemia: Clinical Studies: Poster III 1* 2* 1* 3* Sarah Bertoli, M.D; Ph.D , Noemie Gadaud , Suzanne Tavitian, M.D , Audrey Sarry , Emilie Bérard, M.D; 4,5* 1* 1,6 Ph.D , Françoise Huguet, MD and Christian Recher, MD, PhD 1 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France 3 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 4 Service d'Epidémiologie,, CHU de Toulouse, Toulouse, France 5 UMR 1027, INSERM-Université de Toulouse III, Toulouse, France 6 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 4764 Validation of an Algorithm Identifying Incident Primary Immune Thrombocytopenia in the French National Health Insurance Database Outcomes Research—Non-Malignant Conditions Program: Oral and Poster Abstracts Session: 903. Outcomes Research—Non-Malignant Conditions: Poster III 1* 2* 3* 4* Salim Mezaache , Hélène Derumeaux, MD, PhD , Pierre Ferraro, MD , Pascal Capdebon, MD , Jean5* 6* 7* 8* Christophe Steinbach, MD , Xavier Aballe, MD , Deborah Palas, MD , Nabil Saichi, MD , Franck Burgan, 9* 10* 11* 12* MD , Karine Desboeuf, MD , Maryse Lapeyre-Mestre, MD, PhD , Laurent Sailler, MD, PhD and Guillaume 13,14* Moulis, MD, PhD 1 UMR 1027 INSERM-University of Toulouse, Toulouse, France 2 Department of Medical Information, Toulouse University Hospital, Toulouse, France 3 Department of Medical Information, Auch Hospital, Auch, France 4 Department of Medical Information, Tarbes Hospital, Tarbes, France 5 Department of Medical Information, Castres Hospital, Castres, France 6 Department of Medical Information, Montauban Hospital, Montauban, France 7 Department of Medical Information, Albi Hospital, Albi, France 8 Department of Medical Information, Foix-Pamiers Hospital, Pamiers, France 9 Department of Medical Information, Pont-de-Chaume Hospital, Montauban, France 10 Department of Medical Information, Lavaur Hospital, Lavaur, France 11 Service de Pharmacologie Médicale et Clinique, INSERM U 1027, Toulouse, France 12 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-University of Toulouse, Toulouse, France 13 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France 14 CIC 1436, Toulouse University Hospital, Toulouse, France 3987 Platelet Transfusion Refractoriness Following Induction Chemotherapy in Acute Myeloid Leukemia Acute Myeloid Leukemia: Clinical Studies Program: Oral and Poster Abstracts Session: 613. Acute Myeloid Leukemia: Clinical Studies: Poster III 1* 2* 3* 4* 3* Thibault Comont , Suzanne Tavitian, M.D , Laurent Bardiaux , Marylise Fort , Benedicte Debiol , Daniele 3* 2* 2,5 2* Morere , Françoise Huguet, MD , Christian Récher, MD-Ph.D. and Sarah Bertoli, M.D; Ph.D 1 Service de Médecine Interne, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 3 Etablissement Français du Sang, Toulouse, France 4 Immunology, Toulouse Universitary Hospital, toulouse, France 5 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 2552 Effect of Pregnancy in Women with a History of Primary Immune Thrombocytopenia Considered As Cured Disorders of Platelet Number or Function Program: Oral and Poster Abstracts Session: 311. Disorders of Platelet Number or Function: Poster II 1* 2,3* 1* 1* Thibault Comont , Guillaume Moulis, MD, PhD , Karen Delavigne, MD , Pierre Cougoul, MD , Olivier Parant, 4* 4* 5 1* MD, PhD , Beatrice Guyard Boileau, MD , Christian Récher, MD-Ph.D. , Daniel Adoue, MD, PhD and Odile 1* Beyne Rauzy, MD, PhD 1 Service de Médecine Interne, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France 3 CIC 1436, Toulouse University Hospital, Toulouse, France 4 Department of Obstetrics and Gynecology, Paule de Viguier Hospital - CHU de Toulouse, Toulouse, France Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 5 1718 Outcome of AML Patients with IDH1 or IDH2 Mutations from Diagnosis and Refractory/Relapse Phase of the Disease in Routine Practice Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis Program: Oral and Poster Abstracts Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I 1* 1* 2,3* 4* Sarah Bertoli, M.D; Ph.D , Suzanne Tavitian, M.D , Eric Delabesse, PharmD, PhD , Audrey Sarry , Françoise 4* 1,5 Huguet, M.D and Christian Récher, MD-Ph.D. 1 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France 3 Laboratory of Hematology, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 4 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 5 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 3576 Impact of Non Professional Physicians’ Characteristics on Medical Decision Making in Older Patients with Acute Myeloid Leukemia Health Services Research—Malignant Conditions Program: Oral and Poster Abstracts Session: 902. Health Services Research—Malignant Conditions: Poster II 1,2* 3,4* 5* 1* Pierre Bories, MD , Sébastien Lamy, PhD , Celestine Simand , Sarah Bertoli, M.D; Ph.D , Sandra Malak, 6* 5* 7* 1,8 MD , Luc Mathieu Fornecker, MD, PhD , Stephane Moreau, MD , Christian Recher, MD, PhD and Antoine 9* Nebout, PhD 1 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 2 Réseau régional de cancérologie ONCOMIP, Institut Universitaire du Cancer de Toulouse Oncopole, Toulouse, France 3 Department of clinical pharmacology, Toulouse university hospital, Toulouse, France 4 Laboratory of Epidemiology and Analyses in public health (LEASP) - UMR 1027 Inserm, Toulouse III University, Toulouse, France 5 Haematology, University Hospital, Strasbourg, France 6 Hopital Rene Huguenin-Institut Curie, Saint Cloud, FRA 7 Haematology, University Hospital, Limoges, France 8 Centre de Recherches en Cancérologie de Toulouse, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 9 UR 1303 ALISS,, INRA University Paris-Saclay, Ivry-sur-Seine, France 2138 Daratumumab in Combination with Dexamethasone in Resistant or Refractory Multiple Myeloma: Primary Results of the IFM2014-04 Trial Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 653. Myeloma: Therapy, excluding Transplantation: Poster I 1* 1* 1* 2* Eileen Mary Boyle, MD, MSc , Marie-Odile Petillon, MD , Charles Herbaux, MD , Johanna Mimouni , Xavier 3 4* 5 6* 7* Leleu , Lionel Karlin, MD , Chantal Doyen, MD , Marc Wetterwald, MD, PhD , Muriel Roussel, MD , Cyrille 8* 9* 10* 11* 12* 13* Hulin , Bruno Royer, MD , Margaret Macro , Philippe Moreau , Karel Fostier, MD , Mamoun Dib , 14* 15* 16* 17* Sabine Brechignac, MD , Caroline Bureau , Gerald Marit, MD , Adrian Tempescul, MD , Marie Lorraine 18* 19* 20* 21* 22* Chretien , Charles Zarnitsky , Cecile Fohrer, MD , Aurore Perrot, MD , Lotfi Benboubker, MD, PhD , 23* 24* 25* 26* 27* Laurent Voillat , Jean Valere Malfuson , Clara Mariette , Mourad Tiab , Sophie Rigaudeau , Arnaud 28* 29 30* 31* 32* Jaccard, MD, PhD , Anne-Marie Stoppa , Laure Vincent , Jean Claude Eisenmann, MD , Laurent Frenzel , 33* 34 35 36* Bertrand Arnulf, MD , Mohamad Mohty, MD, PhD , Philippe Rodon, MD , Brigitte Kolb , Olivier Decaux, 37* 38* 1* 1* 1* 1* MD, PhD , Pascal Godmer , David Beauvais , Benjamin Carpentier , Sarah Bonnet, MD , Thomas Longval , 1* 39* 40 41* 42 Mathieu Dewevre , Hervé Avet-Loiseau , Michel Attal , Susanna Schraen, PharmD and Thierry Facon 1 Service des maladies du sang, Lille University Hospital, Lille, France 2 Departement de recherche clinique, Lille University Hospital, Lille, France 3 CHU DE POITIERS, POITIERS, France 4 hematology department, Hospices Civils de Lyon, PIERRE BENITE CEDEX, FRA 5 Department of Hematology, CHU Dinant Godinne UcL, Yvoir, Belgium 6 CHD Dunkerque, Dunkerque, France 7 Institut Universitaire du Cancer and University Hospital, Hematology department, Toulouse, France 8 Bordeaux Hospital University Center (CHU), Bordeaux, France 9 Department of Hematology, University Hospital, Amiens, France 10 Hopital Cote De Nacre, Caen Cedex 9, FRA 11 Department of Hematology, Nantes University Hospital, Nantes, France 12 Uz Brussel, Brussel, BEL 13 Hématologie - CHU - Hôpital du Bocage, Angers, France 14 Hopital Avicenne, bobigny, France 15 Polyclinique Bordeaux Nord Aquitaine, Bordeaux Cedex, FRA 16 hematology department, university hospital, Bordeaux, France 17 Hematology Department, CHU Brest, Brest, France 18 Hématologie Clinique CHU DIJON, Dijon, France 19 Hopital J Monod, Brest, France 20 HEMATOLOGY, CHU, Strasbourg, FRA 21 hematology department, university hospital, Vandoeuvre Les Nancy, France 22 Hôpital Bretonneau Service Hématologie et Thérapies Cellulaires, Centre Régional de Cancérologie Henry Kaplan CHRU de Tours, Tours, France 23 Centre Hospitalier William Morey, Chalons-sur-Saone, France 24 Hôpital d'instruction des armées Percy, Paris Cedex 10, FRA 25 Hematology, Grenoble University Hospital, Grenoble, France 26 University Hospital, La Roche Sur Yon, France 27 Service Hematologie, CHU Andre Mignot, Versailles, France 28 Department of Hematology, Centre National de Référence Maladies Rares: Amylose AL et Autres Maladies à Dépôts, CHU Limoges, Limoges, France 29 Institut Paoli Calmettes, Marseille, France 30 CHU, Montpellier, FRA 31 Hematology Department, CH Mulhouse, Mulhouse, France 32 Hopital Necker, Paris, FRA 33 hematology department, Hôpital Saint Louis, Paris, France 34 Department of Haematology, EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 35 Centre Hospitalier, Perigueux, France 36 Hopital Robert Debre, Reims Cedex, France 37 Internal Medicine, University Hospital CHU Rennes, Rennes, France 38 Department of Hematology, Hospital, Bretagne atlantique, France 39 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 40 Institut Universitaire du Cancer-Oncopole, Toulouse, France 41 Department of biochemistry, Lille Universiy Hospital, Lille, France 42 Service des Maladies du Sang, Hopital Claude Huriez, Lille, France 1743 Impact of Age and Treatment Group in Childhood High Hyperdiploid Low Risk B-Cell Acute Lymphoblastic Leukemia (ALL): Results of the CLG-EORTC 58951 Study Acute Lymphoblastic Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis Program: Oral and Poster Abstracts Session: 618. Acute Lymphoblastic Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster I 1* 2 3* 4 5* Laura Clement , Stefan Suciu, PhD , Isabelle Luquet, M.D , Alina Ferster, MD, PhD , Karima Yakouben, MD , 6* 7* 8* 9* Anne Uytterbroeck , Catherine Paillard, MD PhD , Nicolas Sirvent , Vitor Costa , Barbara De Moerloose, 10* 11 12* 13* 14* MD , Francoise Mazingue , Emmanuel Plouvier, MD , Martine Munzer , Maryline Poirée , Odile Minckes, 15* 16* 17* 18* 19* 20* MD , Frédéric Millot, MD , Dominique Plantaz , Caroline Piette , Frank Speleman, Prof , Hélène Cavé , 21* 22* 23* 24 Jutte VanderWerff-tenBossch , Pierre Simon Rohrlich, MD PhD , Yves Bertrand , Yves Benoit and 25* Geneviève Plat 1 CHU Toulouse, Toulouse, France 2 EORTC Headquarters, Brussels, Belgium 3 Laboratoire d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 4 Dept. of Hémato-oncologie pédiatrique, Children's University Hospital Reine Fabiola, Brussels, Belgium 5 Robert Debre Hospital, AP-HP, Paris, France 6 U.Z. gasthuisberg, Leuven, Belgium 7 Pediatric Hematology, CHU Strasbourg, Strasbourg, France 8 Pediatric Hematology and oncology department, CHU Montpellier, Montpellier, France 9 Instituto Portugues de Oncologia - Centro do Porto, Porto, Portugal 10 Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium 11 hematology, CHRU Lille, Lille, France 12 pediatric hematology, CHRU Besançon, Besançon, France 13 CHU Reims, Reims, France 14 CHU Nice, Nice, France 15 Pediatric Oncology Hematology Department, CHU Caen, Caen, France 16 University Hospital, Poitiers, FRA 17 Department of Pediatric Hematology-Oncology,, CHU Grenoble, Grenoble, France 18 University Department of Pediatric Oncology, CHR Citadelle, Liège, Belgium 19 Center for Medical Genetics, Ghent University, Ghent, Belgium 20 Hôpital Robert Debré, AP-HP, Paris, France 21 U.Z. Gasthuisberg, Leuven, Belgium 22 Hematology-Pediatry, Besan??on, FRA 23 CHU Lyon, Lyon, France 24 Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, University Hospital Ghent, Ghent, Belgium 25 Department of Hematology, CHU Toulouse, Toulouse, France 2128 IFM2012-03 Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 653. Myeloma: Therapy, excluding Transplantation: Poster I 1 2* 3* 4* 5* 6* Xavier Leleu , Guillemette Fouquet , Lionel Karlin, MD , Brigitte Kolb , Mourad Tiab , Carla Araujo , 7 8 9* 10* Nathalie Meuleman, MD, PhD , Jv Malfuson , Pascal Bourquard, MD , Pascal Lenain , Murielle Roussel, 11* 12* 13* 14* 15* MD , Arnaud Jaccard, MD, PhD , Marie-Odile Petillon, MD , Karim Belhadj-Merzoug , Gerard Lepeu , 16* 17* 18 19* 20* Marie-Lorraine Chretien , Jean Fontan , Philippe Rodon, MD , Anna Schmitt, MD , Fritz Offner , Laurent 21* 22* 23* 24* 25* Voillat , Sophie Cereja , Frederique Kuhnowski , Sophie Rigaudeau , Olivier Decaux, MD, PhD , 26* 27* 28* 29* Catherine Humbrecht-Kraut , Jamile Frayfer, MD , Olivier Fitoussi, MD , Damien Roos Weil , Jean Claude 30* 31* 32 33* 34 Eisenmann, MD , Veronique Dorvaux , Eric G. Voog, MD , Cyrille Hulin , Michel Attal , Philippe 35* 36 Moreau and Thierry Facon 1 ONCOLOGIE HEMATOLOGIQUE ET THERAPIE CELLULAIRE, CHU DE POITIERS, POITIERS, France 2 Maladies du Sang, Hôpital Claude Huriez, CHRU Lille, Lille, France 3 Service d'Hématologie, Centre Hospitalier Lyon Sud, Pierre Bénite, France 4 Hopital Robert Debre, Reims Cedex, France 5 University Hospital, La Roche Sur Yon, France 6 Centre Hospitalier de la côte basque, Bayonne, France 7 Hematology, Institut Jules Bordet, ULB, Brussels, Belgium 8 Dept. of Hematology, Hopital Percy, Clamart, France 9 Hopital Caremeau, Nimes, France 10 Centre Henri Becquerel, Rouen, France 11 HEMATOLOGY, IUCT ONCOPOLE, Toulouse, France Department of Hematology, Centre National de Référence Maladies Rares: Amylose AL et Autres Maladies à Dépôts, CHU Limoges, Limoges, France 13 Service des maladies du sang, Lille University Hospital, Lille, France 14 Service Hematologie, CHU Henri Mondor, Creteil, France 15 Service Hematologie, Centre Hospitalier H. Duffaut, Avignon, France 16 Hospital Bocage, Dijon, France 17 Service Hematologie, CHU Besancon, Besancon, France 18 Centre Hospitalier, Perigueux, France 19 Hematology Department, Institut Bergonie, Bordeaux, France 20 Ghent University Hospital, Ghent, Belgium 21 Department of Hematology, Hospital, Chalon sur saone, France 22 Service Hematologie, CH Francilien, Corbeil-Essones, France 23 Service Hematologie, Institut Curie, Paris, France 24 Service Hematologie, CHU Andre Mignot, Versailles, France 25 Internal Medicine, University Hospital CHU Rennes, Rennes, France 26 Service Onco-Hematologie, CH Louis Pasteur, Colmar, France 27 Hématologie, Meaux Hospital, Meaux, France 28 Polyclinique Bordeaux Nord-Aquitaine, Bordeaux, France 29 Service Hematologie, AP-HP Groupe Hospitalier Pitie-Salpetriere, Paris, France 30 Hematology Department, CH Mulhouse, Mulhouse, France 31 Medecine Interne, Hopital Notre Dame de Bon Secours, Metz-Thionville, France 32 Hematology Department, Le Mans, Centre Jean Bernard, Le Mans, France 33 Bordeaux Hospital University Center (CHU), Bordeaux, France 34 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 35 Hematology, University Hospital Hôtel Dieu, Nantes, France 36 Hematology, CHRU Lille Hôpital Claude Huriez, Lille, Lille, France 12 3128 Myelofibrosis in Real Life: Findings from the French Intergroup of Myeloproliferative Neoplasms (FIM) Registry Myeloproliferative Syndromes: Clinical Program: Oral and Poster Abstracts Session: 634. Myeloproliferative Syndromes: Clinical: Poster II 1 2* 3* 4* Brigitte Dupriez, MD , Sylvie Chevret, MD, PhD , Jean-Christophe Ianotto, MD , Francoise Boyer, MD , 5* 6* 7* 8* Pascale Cony-Makhoul, MD , Gabriel Etienne, MD, PhD , Mathieu Wemeau, MD , Jérome Rey , Laurent 9* 10 3* 11 Knoops, MD, PhD , Jean-Loup Demory, MD , Eric Lippert, PhD , Francois Girodon, MD, PhD , Laurence 12* 13* 14* 15* Legros, MD, PhD , Anne Vekhoff, MD , Stephane Courby, MD , Fabienne Vacheret, MD , Nathalie 16* 17* 18* 19* Cambier, MD , Stephane Giraudier, MD, PhD , Suzanne Tavitian, M.D , Kamel Laribi, MD , Sandra 20* 21* 22* 23* 24* Malak , Dana Ranta, MD , Fiorenza Barraco, MD , Isabelle Plantier, MD , Sophie Dupire , Marc Simon, 25* 26* 27* 28 29* MD , Selim Corm, MD , Ahmad AL Jijakli, MD , Philippe Rodon, MD , Lise Willems, MD, PhD , Bohrane 30* 31* 32* 33* Slama, MD , Ronan Le Calloch, MD , Pierre Morel, MD , Valerie Ugo, MD, PhD and Jean-Jacques 34 Kiladjian, MD, PhD 1 Service Hematologie Clinique, Centre hospitalier de Lens, Lens, France 2 Biostatistics department, Hôpital Saint-Louis, Paris, France 3 Centre Hospitalier Universitaire, Brest, France 4 Centre Hospitalier Universitaire, Angers, France 5 Centre Hospitalier Annecy-Genevois, Pringy, France 6 Hematology Department, Institut Bergonie, Bordeaux, France 7 CH, Arras, France 8 Hematology Department, Institut Paoli Calmettes, Marseille, France 9 Cliniques Universitaires Saint-Luc and de Duve Institute, Université catholique de Louvain, Brussels, Belgium 10 Hôpitaux de l'Université Catholique de Lille, Lille, France 11 Hospital University Center (CHU), Dijon, France 12 Hematology department, Hopital Archet 1, CHU Nice, Nice, France 13 Hematology and Cellular Therapy, Saint Antoine Hospital, Paris, France 14 Hematology department, CHU Grenoble, Grenoble, France 15 CH, Perpignan, France CHRU, Lille, France 17 Hôpital Henri-Mondor, Créteil, France 18 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 19 Centre Hospitalier, Le Mans, France 20 CHU Curie, Paris, France 21 Centre Hospitalier Universitaire, Nancy, Nancy, France 22 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 23 CH, Roubaix, France 24 CH, Bourg en Bresse, France 25 Centre Hospitalier, Valenciennes, France 26 Médipole de Savoie, Challes Les Eaux, France 27 CH Argenteuil, Argenteuil, France 28 Centre Hospitalier, Perigueux, France 29 Cochin Hospital, University Paris 5, Paris, France 30 CH, Avignon, France 31 CH, Quimper, France 32 Department of Hematology, University Hospital, Amiens, France 33 Laboratoire Hematologie, CHU Angers, Angers, France 34 Hôpital Saint-Louis and Paris Diderot University, Paris, France 16 241 Final Analysis of Overall Survival from the First Trial Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Clinical Studies, Minimal Residual Disease, and Biomarkers 1 2 3 4 5 Thierry Facon , Meletios Dimopoulos , Angela Dispenzieri , John V. Catalano , Andrew Belch , Michele Cavo, 6* 7* 8* 9 10,11 12* 13* MD , Antonello Pinto , Katja Weisel , Heinz Ludwig , Nizar J. Bahlis, MD , Anne Banos , Mourad Tiab , 14 15 16* 17 18* 19* Michel Delforge , Jamie D. Cavenagh , Catarina Geraldes , Je-Jung Lee , Christine Chen , Albert Oriol , 20* 21 22 23 24 25* Javier De La Rubia , Darrell White , Daniel Binder , Jin Lu , Kenneth C. Anderson , Philippe Moreau , 26 27 28* 29 29* Michel Attal , Jean-Paul Fermand , Hervé Avet-Loiseau , Annette Ervin-Haynes , Guang Chen , Vanessa 29* 30* 31* Houck , Cyrille Hulin and Lofti Benboubker 1 Service des Maladies du Sang, Hopital Claude Huriez, Lille, France 2 National and Kapodistrian University of Athens, School of Medicine, Athens, Greece 3 Mayo Clinic, Rochester, MN 4 Frankston Haematology and Oncology Center, Frankston, Australia 5 Cross Cancer Institute, Edmonton, AB, Canada 6 Seràgnoli Institute of Hematology, Bologna University School of Medicine, Bologna, Italy 7 Hematology-Oncology and Stem Cell Transplantation Unit, National Cancer Institute, Fondazione Pascale, IRCCS, Napoli, Italy 8 University of Tuebingen, Tuebingen, Germany 9 Wilhelminen Cancer Research Institute, Department of Medicine, Center of Oncology, Hematology and Palliative Care, Wilhelminenspital, Vienna, Austria 10 University of Calgary, Arnie Charbonneau Cancer Institute, Calgary, AB, Canada 11 University of Calgary, Calgary, AB, Canada 12 Centre Hospitalier de la Cote basque, Bayonne, France 13 University Hospital, La Roche Sur Yon, France 14 Department of Hematology, UZ Leuven, Leuven, Belgium 15 Department of Haemato-Oncology, St Bartholomew's Hospital, Barts Health NHS Trust, London, United Kingdom 16 Hospitals da Universadade de Combra, Combra, Portugal 17 Department of Hematology-Oncology, Chonnam National University Hwasun Hospital, Jeollanamdo, Korea, The Republic of 18 Princess Margaret Cancer Centre, Toronto, ON, Canada 19 Hospital Germans Trias i Pujol, Barcelona, Spain Hospital Universitari i Politècnic La Fe, Valencia, Spain 21 QEII Health Sciences Center, Dalhousie University, Halifax, NS, Canada 22 Kantonsspital Winterthur, Winterthur, CHE 23 Peking University Institute of Hematology, Peking University People’s Hospital, Beijing, China 24 Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 25 University of Nantes, Nantes, France 26 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 27 Hopital Saint-Louis, Paris, France 28 Unite de Genomique du Myelome, CHU Rangueil, Toulouse, France 29 Celgene Corporation, Summit, NJ 30 Bordeaux Hospital University Center (CHU), Bordeaux, France 31 CHU Tours Hopital Bretonneau, Tours, France 20 3569 Assessment of Mobilization Cost for Multiple Myeloma Using 2 Different Mobilization Strategies: HighDose Cyclophosphamide Versus Plerixafor. on Behalf of IFM Health Services Research—Malignant Conditions Program: Oral and Poster Abstracts Session: 902. Health Services Research—Malignant Conditions: Poster II 1* 2* 3* 4* 5 Zoe van de Wyngaert , Nabih Azar, MD , Pascal Lenain , Margaret Macro , Jean-Henri Bourhis, MD, PhD , 6 7* 8* 9* Laurent Garderet, MD , Arnaud Jaccard, MD, PhD , Lionel Karlin, MD , Christine Giraud , Stéphanie Guidez, 10* 11* 12* 13* 14* MD , Benjamin Hebraud , Muriel Roussel, MD , Gerald Marit, MD , Cyrille Hulin, MD , Eric Deconinck, 15 16 17* 18* 19* 20 MD, PhD , Michel Attal , Philippe Moreau , Denis Caillot , Samuel Limat, PhD , Xavier Leleu and Marie21* Lorraine Chretien 1 Service des Maladies du sang, hopital claude hurriez, CHRU lille, Lille, France 2 Service d'Hématologie Clinique, Hôpital de la Pitié-Sâlpétrière, PARIS CEDEX 13, France 3 Centre Henri Becquerel, Rouen, France 4 Haematology Department, Caen University Hospital, Caen, France 5 Division of Hematology, Institut Gustave Roussy, Villejuif, France 6 Hematology Department, CHU St Antoine, Paris, France 7 Department of Hematology, Centre National de Référence Maladies Rares: Amylose AL et Autres Maladies à Dépôts, CHU Limoges, Limoges, France 8 hematology department, Hospices Civils de Lyon, PIERRE BENITE CEDEX, FRA 9 CHU de POITIERS, Poitiers, FRA 10 Oncologie hématologique et thérapie cellulaire, CHU Poitiers, Poitiers, France 11 CHU Toulouse, TOULOUSE, FRA 12 Institut Universitaire du Cancer and University Hospital, Hematology department, Toulouse, France 13 hematology department, university hospital, Bordeaux, France 14 hematology department, university hospital, bordeaux, France 15 Hematology, INSERM UMR1098 - CHU Jean Minjoz, Besancon, France 16 Institut Universitaire du Cancer-Oncopole, Toulouse, France 17 Department of Hematology, Nantes University Hospital, Nantes, France 18 Hématologie Clinique, Dijon University Hospital, Dijon, France 19 Pharmacy, CHRU Besancon, Université de Bourgogne Franche -comté, Besançon, France 20 ONCOLOGIE HEMATOLOGIQUE ET THERAPIE CELLULAIRE, CHU DE POITIERS, POITIERS, France 21 Hospital Bocage, Dijon, France 3476 Allogeneic Stem Cell Transplantation in First Chronic Phase CML during the Last Decade: Retrospective Analysis of the National SFGM-TC Registry Clinical Allogeneic Transplantation: Results Program: Oral and Poster Abstracts Session: 732. Clinical Allogeneic Transplantation: Results: Poster II 1,2 2,3* 4 Franck-Emmanuel Nicolini, MD, PhD , Valerie Coiteux, MD , Gerard Socie, MD, PhD , Didier Blaise, MD, 5 6 7* 8* PhD , Eric Deconinck, MD, PhD , Patrice Chevallier, MD, PhD , Pierre Simon Rohrlich , Stephanie Nguyen, MD, 9* 10 11 12* PhD , Thierry Lamy, MD PhD , Jean-Henri Bourhis, MD, PhD , Marie-Thérèse Rubio, MD, PhD , Felipe Suarez, 13 14* 15 16* 17 MD, PhD , Jerome Cornillon, MD , Gandhi Damaj, MD , Natacha Maillard, MD , Noel Milpied, MD PhD , 18* 19 20* 21* Patrice Ceballos, MD , Mohamad Mohty, MD, PhD , Claude-Eric Bulabois, MD , Bruno Lioure, MD , Gerard 22* 23 24 25* 26* Michel, MD , Norbert Ifrah , Yves Beguin, MD, PhD , Anne Huynh, MD , Nathalie Contentin, MD , 27 28* 29* Jacques-Olivier Bay, MD, PhD , Yves Bertrand, MD, PhD , Yves Perel, MD , Jean-Hugues Dalle, MD, PhD, 30 31* 32* 33* Prof. , Gaelle Guillerm, MD , jean-Valere Malfuson, MD , Aude Marie-Cardine, MD , Mauricette Michallet, 2,34 35* 36* 34* MD, PhD , Nicole Raus, Data Manager , Marie Balsat, MD , Helene Labussiere, MD , Regis Peffault De 4* 37 Latour, MD, PhD and Ibrahim Yakoub-Agha, MD, PhD 1 Centre Hospitalier Lyon Sud, Hématologie clinique 1G, Pierre Bénite, France 2 Fi-LMC group, Pessac, France 3 Hematology, CHU de Lille, Lille, France 4 Hematology / Transplantation, Saint Louis Hospital, Paris, France 5 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 6 Hematology, INSERM UMR1098 - CHU Jean Minjoz, Besancon, France 7 Department of Hematology, Nantes University Hospital, Nantes, France 8 Pediatric Oncology, CHU Nice, Nice, France 9 Department of hematology, Pitie Salpetriere Hospital, Paris, France 10 INSERM U917, CHU Pontchaillou, Rennes, France 11 Gustave Roussy Cancer Center, Villejuif, France 12 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 13 Hôpital Universitaire Necker-Enfants Malades, Paris, France 14 Department of Hematology, Institut de Cancérologie Lucien Neuwirth, Saint-Etienne, France 15 Hematology Department, CHU Caen, Caen, France 16 Bone Marrow Transplant Unit Clinical Hematology, Hopital La Miletrie, Poitiers, France 17 Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Leveque and University of Bordeaux, Bordeaux, France 18 Hematology, CHU Lapeyronie, Montpellier, France 19 Department of Haematology, EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 20 Hematology, CHU Grenoble, Grenoble, France 21 Hematology and Oncology, Hopital Hautepierre, Strasbourg, France 22 Hematology, CH Timone, Marseille, France 23 Hematology, Angers University Hospital, Angers, France 24 Hematology, University and CHU of Liege, Liege, Belgium 25 Institut Universitaire du Cancer, Oncopole IUCT, Toulouse, France 26 Hematology, Centre Henri Becquerel, Rouen, France 27 Hematology department, CHU Clermont Ferrand, Clermont Ferrand, France 28 Department of Pediatric Hematology and Oncology, University Hospital of Lyon, Lyon, France 29 Pediatric Hematology department, CHU Pellegrin, Bordeaux, France 30 Pediatric Hematology Department, Robert Debre Hospital, Paris, France 31 Hematology and Oncology, CH Augustin Morvan, Brest, France 32 Military Hospital, Clamart, France 33 Pediatric Hematology department, Charles Nicolle Hospital, Rouen, France 34 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 35 SFGM-TC, Lyon, France 36 Hématologie Clinique, Lyon-Sud Hospital, Pierre Benite, France 37 Hematology, Hôpital HURIEZ UAM allogreffe de CSH, CHRU, Lille, France 3696 Antifungal Prophylaxis in AML Patients Receiving Intensive Induction Chemotherapy. Prospective Observational Study from the Acute Leukemia French Association (ALFA) Group Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections Program: Oral and Poster Abstracts Session: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III 1 1* 1* Mauricette Michallet, MD, PhD , Mohamad Sobh, PharmD , Alexandre Deloire, CRA , Emmanuel Raffoux, 2* 3* 4* 5 6* MD , Stephane de Botton , Denis Caillot , Oumedaly Reman, MD , Stephane Girault, MD , Celine Berthon, 7* 8* 9* 10* 11 MD, PhD , Francoise Huguet, MD , Stephane Lepretre , Thibaut Leguay, MD , Sylvie Castaigne, MD, PhD , 12* 13* 14* 15* Bruno Royer, MD , Cecile Pautas, MD , Jean-Valere Malfuson, MD , Jose Fernandes, MD , Thomas Prebet, 16* 17* 18* 19 20* MD , Thorsten Braun, MD , Lauris Gastaud, MD , Felipe Suarez, MD, PhD , Aline Schmidt, MD , Remy 21 22* 23* 24* Gressin, MD , Jacques Delaunay, MD , Caroline Bonmati, MD , Karine Celli-Lebras, CRA , Mohamed El1* 2 1 25* Hamri, CRA , Herve Dombret, MD, PhD , Xavier Thomas, MD, PhD and Anne Bergeron, MD, PhD 1 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 2 Hematology Department, Saint Louis Hospital, Paris, France 3 Institut Gustave Roussy, Villejuif, France 4 Hématologie Clinique, Dijon University Hospital, Dijon, France 5 Hematology, CHU Caen, Caen, France 6 Hematology, Limoges university hospital, Limoges, France 7 Hematology, CHRU de Lille, Lille, France 8 Hématologie, Toulouse Cancer University Institute, Toulouse, France 9 Hematology, Henri Becquerel Anti-Cancer Center, Rouen, France 10 Hematology, CHU Bordeaux, Pessac, France 11 Hematology, Hopital Mignot, Le Chesnay, France 12 Department of Hematology, University Hospital, Amiens, France 13 Hematology, Henri Mondor Hospital, Creteil, France 14 Hematology, Military Hospital, Clamart, France 15 Hematology, Centre Hospitalier Valenciennes, Valenciennes, France 16 Hematology, Institut Paoli-Calmettes, Marseille, France 17 Hematology, Avicenne Hospital, APHP, Bobigny, France 18 Hematology, Centre Antoine Lacassagne, Nice, France 19 Hôpital Universitaire Necker-Enfants Malades, Paris, France 20 Hematology, CHU angers, Angers, France 21 Hematology, CHU Grenoble, Grenoble, France 22 Hematology, Nantes University Hospital, Nantes, France 23 Hematology, CHU Nancy, Nancy, France 24 ALFA group, Paris, France 25 Pneumology, Saint Louis Hospital, Paris, France ???? 3450 Bendamustine-Based (BeEAM) Conditioning before Autologous Stem Cell Transplantation: Result of a French Multicenter Study of 386 Patients from Lysa Centers Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Session: 731. Clinical Autologous Transplantation: Results: Poster II 1* 2* 3* Sylvain Chantepie, MD , Emmanuelle Tchernonog, MD , Frederic Peyrade, MD , Marie-Virginie Larcher, 4* 5* 6* 7* 8* MD , Momar Diouf, MD , Luc Mathieu Fornecker, MD, PhD , Roch Houot, MD, PhD , Thomas Gastinne, MD , 9 10* 11* 12* Carole Soussain, MD, PhD , Sandra Malak, MD , Olivier Tournilhac, MD, PhD , Caroline Delette , Ahmad 13* 1* 14* 15* Ibrahim , Anne-Claire Gac, MD , Jean-Pierre Vilque, MD , Mohamed Amine Bekadja , Rene-Olivier 16* 17 18* 19* Casasnovas, MD , Remy Gressin, MD , Arnaud Jaccard, MD, PhD , Benjamin Carpentier , Reda Garidi, 20* 21* 22* 23* 24* MD , Bachra Choufi, MD , Stéphanie Guidez, MD , Adrian Tempescul, MD , Adrien Chauchet, MD , 25 26 27* Emmanuel Gyan, MD, PhD , Ibrahim Yakoub-Agha, MD, PhD , Krimo Bouabdallah, MD , Eric Durot, 28* 29 MD and Gandhi Damaj, MD 1 Institut d'Hématologie de Basse-Normandie, CHU, Caen, France 2 Department of Clinical Hematology, University Hospital Montpellier, Montpellier, France 3 Hematology Department, Centre Antoine Lacassagne, Nice, France 4 Hematology, Toulouse University Hospital, Toulouse, France 5 Amiens University hospital, Amiens, France 6 Haematology, University Hospital, Strasbourg, France 7 Hematology, University hospital, Rennes, France 8 Department of Hematology, Nantes University Hospital, Nantes, France 9 Dept. of hematology, Curie Institute, Hôpital René Huguenin, Saint-Cloud, France 10 Hopital Rene Huguenin-Institut Curie, Saint Cloud, FRA 11 Service d'Hematologie Clinique et de Therapie Cellulaire, CHU, Universite d'Auvergne, EA7283, CIC501, Clermont-Ferrand, Clermont Ferrand, France 12 Oncopole Hopital Sud, Amiens, FRA 13 Makassed General Hospital, Beirut, LBN 14 Institut d'Hématologie de Basse-Normandie, Centre François Baclesse, Caen, France 15 Hematology and Cell Therapy, Etablissement Hospitalier Universitaire (EHU) 1st November, Oran, Algeria 16 Hematology, University Hospital, Dijon, France 17 Hematology, CHU Grenoble, Grenoble, France 18 Department of Hematology, Centre National de Référence Maladies Rares: Amylose AL et Autres Maladies à Dépôts, CHU Limoges, Limoges, France 19 Service des maladies du sang, Lille University Hospital, Lille, France 20 Hospital, Saint Quentin, France 21 Service d'Hématologie, CH Boulogne sur Mer, BOULOGNE SUR MER, France 22 Oncologie hématologique et thérapie cellulaire, CHU Poitiers, Poitiers, France 23 Hematology, Brest University Hospital, Brest, France 24 Hematology, CHU, Besancon, France 25 Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France 26 Hematology, Hôpital HURIEZ UAM allogreffe de CSH, CHRU, Lille, France 27 Haematology, CHU de Bordeaux, Bordeaux, France 28 Department of Hematology, Centre Hospitalier Universitaire, Reims Cedex, FRA 29 Hematology Department, CHU Caen, Caen, France 895 Is Arsenic Trioxide (ATO) Required in the Treatment of High Risk Newly Diagnosed APL? Analysis of a Randomized Trial (APL2006) By the French Belgian Swiss APL Group Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 615. Acute Myeloid Leukemia: Commercially Available Therapy, excluding Transplantation: APL and other AML Specific Subsets 1 2* 3 4* Lionel Ades, MD, PhD , Emmanuel Raffoux, MD , Olivier Spertini , Agnès Guerci, MD, PhD , Christian Recher, 5 6* 7 8* 9 MD, PhD , Denis Guyotat , Eric Deconinck, MD, PhD , Thierry Lamy De La Chapelle , Xavier Thomas, MD, PhD , 10 11,12 13* 14,15* Dominique Bordessoule, MD, PhD , Norbert Vey , Stephane de Botton , Arnaud Pigneux, MD , Denis 16* 17 18* 19 Caillot , Jean-Yves Cahn, MD , Patrice Chevallier, MD, PhD , Jean-Francois Lambert, MD , Claude Gardin, 20* 21* 22* 23* 24 MD, PhD , Herve Dombret , Julie Lejeune , Sylvie Chevret and Pierre Fenaux, MD, PhD 1 Service d’Hématologie Séniors,, St Louis hospital, University Paris 7, Paris, France 2 Hematology Department, Saint-Louis Hospital, Paris, France 3 Hematology, CHUV, Lausanne, Switzerland 4 Hématologie Clinique, CHU Nancy-Brabois, Vandoeuvre, France 5 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 6 Hematology, Lucien Neuwirth Cancer Institute, Saint-Priest-en-Jarez, France 7 Hematology, INSERM UMR1098 - CHU Jean Minjoz, Besancon, France 8 Universite de Rennes, Rennes Cedex 9, FRA 9 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 10 Hematology, Limoges University Hospital, Limoges, France 11 Department of Hematology, Institut Paoli Calmettes, Marseille, France 12 Aix Marseille Université, Marseille, France 13 Institut Gustave Roussy, Villejuif, France 14 Hôpitaux du Haut Lévéque CHU Bordeaux, Pessac, France 15 INSERM UMR 1035, Bordeaux University, Bordeaux, France 16 Hématologie Clinique, Dijon University Hospital, Dijon, France 17 Hematology, CHU Grenoble Alpes, Grenoble, France 18 Department of Hematology, Nantes University Hospital, Nantes, France 19 Hospital of Nyon, Nyon, Switzerland 20 Hematology Department, Avicenne Hospital, APHP, University Paris 13, Bobigny, France Hematology, Hôpital Saint-Louis, Paris, France 22 Hôpital Saint Louis, Assistance Publique - Hôpitaux de Paris, Paris, France 23 Statistics St-Louis Hospital, Paris 7, Paris, France 24 Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France 21 4612 Long Term Follow-up of Hematopoietic Stem Cell Transplantation (HSCT) for Primary Plasma Cell Leukemia (pPCL): Final Results of a Prospective Study of IFM Group Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence Program: Oral and Poster Abstracts Session: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Poster III 1* 2* 3* 4* 5* Bruno Royer, MD , Momar Diouf , Murielle Roussel , Lionel Karlin, MD , Cyrille Hulin , Bertrand Arnulf, 6* 7* 8* 9* 10* 11* MD , Margaret Macro , Sylvie Cailleres , Annie Brion, MD , Sabine Brechignac, MD , Karim Belhadj, MD , 12* 13* 14* 15* 16 Marie Lorraine Chretien , Marc Wetterwald, MD, PhD , Carine Chaleteix , Mourad Tiab , Xavier Leleu , 17* 18 19* 20* Laurent Frenzel , Laurent Garderet, MD , Sylvain Choquet, MD , jean Gabriel Fuzibet , Charles Dauriac, 21* 22* 23* 24 25* MD , luc-Matthieu Fornecker , Lotfi Benboubker, MD, PhD , Thierry Facon , Philippe Moreau , Hervé 26* 27* 28 Avet-Loiseau , Stephane Minvielle and Jean Pierre Marolleau, MD, PhD 1 Department of Hematology, University Hospital, Amiens, France 2 University Hospital, Amiens, France 3 Institut Universitaire du Cancer, toulouse, France 4 Service d'Hématologie, Centre Hospitalier Lyon Sud, Pierre Bénite, France 5 Bordeaux Hospital University Center (CHU), Bordeaux, France 6 hematology department, Hôpital Saint Louis, Paris, France 7 Haematology Department, Caen University Hospital, Caen, France 8 Centre hospitalier, aix en Provence, France 9 Hopital Jean Minjoz, Besancon, France 10 Hopital Avicenne, bobigny, France 11 CHU Henri Mondor, Creteil, France 12 CHRU Dijon, Dijon, France 13 CHD Dunkerque, Dunkerque, France 14 university hospital, Clermont Ferrand, France 15 University Hospital, La Roche Sur Yon, France 16 CHU DE POITIERS, POITIERS, France 17 Hopital Necker, Paris, FRA 18 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 19 Department of Clinical Hematology, Pitie-Salpetriere Hospital and Pierre et Marie Curie University, Paris, France 20 University hospital, Nice, France 21 Hematology, CHU Rennes, Rennes, France 22 university hospital, strasbourg, France 23 Hôpital Bretonneau Service Hématologie et Thérapies Cellulaires, Centre Régional de Cancérologie Henry Kaplan CHRU de Tours, Tours, France 24 Hematology, CHRU Lille Hôpital Claude Huriez, Lille, Lille, France 25 Department of Hematology, Nantes University Hospital, Nantes, France 26 Institut Universitaire du Cancer and University Hospital, Unité de Génomique du Myélome, Toulouse, France 27 Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France 28 Unit of Hematology, University Hospital, Amiens, France 4018 Hyper-CVAD Plus Epratuzumab As Salvage Regimen for Younger Relapsed/Refractory CD22+ B Acute Lymphoblastic Leukemia (ALL) Patients: Results of the Phase 2 Prospective Cheprall Study Acute Lymphoblastic Leukemia: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 614. Acute Lymphoblastic Leukemia: Therapy, excluding Transplantation: Poster III 1* 2* 3* Patrice Chevallier, MD, PhD , Sylvain Chantepie, MD , Françoise Huguet, MD , Emmanuel Raffoux, MD, 4* 5 6* 7* 8* PhD , Xavier Thomas, MD, PhD , Thibaut Leguay, MD , Tony Marchand, MD , Francoise Isnard, MD PhD , 9* 10* 11* 12* Aude Charbonnier , Sebastien Maury, MD, PhD , Maria-Pilar Gallego-Hernanz, MD , Nelly Robillard, PhD , 1* 13* 1* 14* Thierry Guillaume, MD, PhD , Pierre Peterlin, MD , Alice Garnier, MD , Fanny Rialland, MD , Claire Le 15* 16 16 Houerou , David M Goldenberg, ScD, MD , William Wegener, MD, PhD , Marie C Bene, PharmSciD, 17* 18 PhD and Herve Dombret, MD 1 Department of Hematology, Nantes University Hospital, Nantes, France 2 Institut d'Hématologie de Basse-Normandie, CHU, Caen, France 3 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 4 Hematology Department, Saint Louis Hospital, Paris, France 5 CHU, Lyon, France 6 Hematology, CHU Bordeaux, Pessac, France 7 Department of Hematology, Centre Hospitalier Universitaire de Rennes, Rennes, France 8 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 9 Hematology department, Institut Paoli Calmettes, Marseille, France 10 Hopital Henri Mondor, Creteil, FRA 11 Hematology Department, CHU, Poitiers, France 12 Hematology Laboratory, Nantes University Hospital, Nantes, France 13 HOPITAL HOTEL DIEU ET HME, NANTES CEDEX 1, FRA 14 Oncopediatrics Department, Nantes University Hospital, Nantes, France 15 Hematology Department, CHU, Nantes, France 16 Immunomedics, Inc., Morris Plains, NJ 17 Departement of Immunology, Centre Hospitalier Universitaire, Nantes, France 18 Hopital Saint Louis, Paris, France 3470 Triage Scoring System Based on Early Post-Transplant Complications for Patients with Myelodysplastic Syndrome Requiring ICU after Allo-HCT: An SFGM-TC Study Clinical Allogeneic Transplantation: Results Program: Oral and Poster Abstracts Session: 732. Clinical Allogeneic Transplantation: Results: Poster II 1* 2* 3 4 5 Alexis Caulier , Elodie Drumez , Marie Robin, MD, PhD , Didier Blaise, MD, PhD , Yves Beguin, MD, PhD , 6 7* 8 Mauricette Michallet, MD, PhD , Patrice Chevallier, MD, PhD , Jacques-Olivier Bay, MD, PhD , Stéphane 9* 10* 11* 12* Vigouroux, MD , Yohan Desbrosses , Jérôme Cornillon, MD , Stephanie Nguyen, MD, PhD , Regis Peffault 13* 14* 15* 16* De Latour, MD, PhD , Charles Dauriac, MD , Bruno Lioure, MD , Pierre Simon Rohrlich , Martin Carré, 17* 18 19* 20 21* MD , Jean-Henri Bourhis, MD, PhD , Anne Huynh, MD , Felipe Suarez, MD, PhD , Federico Garnier, MD , 22* 23 Alain Duhamel, MD, PhD and Ibrahim Yakoub-Agha, M.D.- PhD 1 Hematology and cellular therapy, CHU Amiens Sud, Amiens Cedex 1, France 2 Santé publique : épidémiologie et qualité des soins, Université de biostatistiques - CHU Lille, Lille, France 3 Hematology / Transplantation, Saint-Louis Hospital, Paris, France 4 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 5 Hematology, University and CHU of Liege, Liege, Belgium 6 Department of Hematology, Centre Hospitalier Lyon-Sud, Lyon, France 7 Department of Hematology, Nantes University Hospital, Nantes, France 8 Hematology department, CHU Clermont Ferrand, Clermont Ferrand, France 9 University Hospital of Bordeaux, Bordeaux, France 10 Department of hematology, CHU Jean Minjoz, Besançon, France 11 Department of Hematology, Saint-Etienne University Hospital, Saint-Etienne, France 12 Department of hematology, Pitie Salpetriere Hospital, Paris, France 13 Hematology / Transplantation, Saint Louis Hospital, Paris, France 14 Hematology, CHU Rennes, Rennes, France 15 Hematology and Oncology, Hopital Hautepierre, Strasbourg, France 16 Pediatric Oncology, CHU Nice, Nice, France 17 Department of Hematology, CHU Grenoble, Grenoble, France 18 Gustave Roussy Cancer Center, Villejuif, France 19 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole-CHU de Toulouse, Toulouse, France 20 Hôpital Universitaire Necker-Enfants Malades, Paris, France 21 agence de la biomédecine, Saint Denis, France 22 Santé publique : épidémiologie et qualité des soins, Université de biostatistiques - CHRU Lille, Lille, France 23 Hematological department, Lille University Hospital, Lille, France 3920 Unique Long Non-Coding RNA Expression Signature in ETV6/RUNX1-Driven B-Cell Precursor Acute Lymphoblastic Leukemia Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation Program: Oral and Poster Abstracts Session: 602. Disordered Gene Expression in Hematologic Malignancy, including Disordered Epigenetic Regulation: Poster III 1,2* 2,3* 1* 1* 4 Farzaneh Ghazavi , Barbara De Moerloose, MD , Wouter Van Loocke , Annelynn Wallaert , Alina Ferster , 5* 6* 7* 8* Marleen Bakkus, PhD , Genevieve Plat, MD , Eric Delabesse, PharmD, PhD , Anne Uyttebroeck , Filip Van 9* 9* 1,3* Nieuwerburgh, PharmD, Prof , Dieter Deforce, PharmD, Prof , Nadine van Roy, MD, Prof , Frank Speleman, 1,3* 10 2,3* 1,3* Prof , Yves Benoit , Tim Lammens and Pieter van Vlierberghe, Prof 1 Center for Medical Genetics, Ghent University Hospital, Ghent, Belgium 2 Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, Ghent University Hospital, Ghent, Belgium 3 Cancer Research Institute Ghent (CRIG), Ghent, Belgium 4 Department of Hemato-Oncology, HUDERF, Brussels, Belgium 5 Department of Hematology, University Hospital Brussels, Vrije Universiteit Brussel (VUB), Brussels, Belgium 6 Department of Hematology, CHU Toulouse, Toulouse, France 7 Laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France 8 Department of Pediatric Hemato-Oncology, University Hospital Leuven, Leuven, Belgium 9 Laboratory of Pharmaceutical Biotechnology, Ghent University, Ghent, Belgium 10 Department of Pediatric Hematology-Oncology and Stem Cell Transplantation, University Hospital Ghent, Ghent, Belgium 196 The Multiple Myeloma Genome Project: Development of a Molecular Segmentation Strategy for the Clinical Classification of Multiple Myeloma Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Prognostic Factors 1 2* 3* 1* Brian A Walker, PhD , Mehmet K. Samur, PhD , Konstantinos Mavrommatis , Cody Ashby, PhD , Christopher 1* 4* 5* 1* 1* P Wardell, PhD , Maria Ortiz, PhD , Fadi Towfic , Caleb K. Stein, MS , Michael A Bauer, PhD , Michael 5* 6* 5* 4* 7,8* Amatangelo, PhD , Giovanni Parmigiani, PhD , Zhinuan Yu, PhD , Matthew Trotter , Hervé Avet-Loiseau , 9 10 5* 10 Graham H Jackson, MD, PhD , Kenneth C. Anderson , Anjan Thakurta, Ph.D. , Nikhil C. Munshi, MD and 1 Gareth J Morgan, MD, PhD 1 Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR 2 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 3 Celgene Corporation, San Francisco, CA 4 Celgene Institute for Translational Research Europe, Celgene Corporation, Seville, Spain 5 Celgene Corporation, Summit, NJ 6 Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 7 Centre de Recherche en Cancérologie de Toulouse Institut National de la Santé et de la Recherche Médicale, Toulouse, France 8 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 9 Department of Haematology, Royal Victoria Infirmary, Newcastle upon Tyne, United Kingdom 10 Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 4230 Management of Post-Transplant Lymphoproliferative Disorders in the Real Life: The French Attitude Between 2010 and 2013 Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)—Results from Retrospective/Observational Studies Program: Oral and Poster Abstracts Session: 627. Aggressive Lymphoma (Diffuse Large B-Cell and Other Aggressive B-Cell Non-Hodgkin Lymphomas)—Results from Retrospective/Observational Studies: Poster III 1* 1* 2* 3* 4* Inès Boussen , Caroline Algrin, MD , Julien Rossignol, MD , Eric Durot, MD , Sarah Guenounou , Antoine 5* 6* 7 8 9 Bonnet , Jeremy Delage, MD , Emmanuel Gyan, MD, PhD , Fontanet Bijou, MD , Noel Milpied, MD , Adrien 10* 11* 12 13* Chauchet, MD , Adrien Tempescul, MD , Gandhi Damaj, MD , Arnaud Jaccard, MD, PhD , Jerome 14* 15 16 1* Cornillon, MD , Norbert Ifrah , Veronique Leblond and Sylvain Choquet, MD 1 Department of Clinical Hematology, Pitie-Salpetriere Hospital and Pierre et Marie Curie University, Paris, France 2 Department of Hematology, Necker Children's hospital, APHP, Paris, France 3 Department of Hematology, Centre Hospitalier Universitaire, Reims Cedex, FRA 4 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 5 Department of Hematology, University of Nantes, Nantes, France 6 CHU Lapeyronie, Département d`Hématologie Clinique, Montpellier, FRA 7 Department of Clinical Hematology, CHRU de Tours, Tours, France 8 Institut Bergonie, Bordeaux, France 9 Service d’Hematologie Clinique et Therapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France 10 Hematology, CHU, Besancon, France 11 Haematology, University Hospital, Brest, France 12 Hematology Department, CHU Caen, Caen, France 13 Department of Hematology, Centre National de Référence Maladies Rares: Amylose AL et Autres Maladies à Dépôts, CHU Limoges, Limoges, France 14 Department of Hematology, Institut de Cancérologie Lucien Neuwirth, Saint-Etienne, France 15 Hematology, Angers University Hospital, Angers, France 16 Department of Clinical Hematology, AP-HP Hôpital Pitié-Salpêtrière, Paris, France 2555 Autologous 111 Indium-Oxinate-Labelled Platelet Sequestration Study in Patients with Immune Thrombocytopenia Treated By Thrombopoietic Receptor-Agonists Disorders of Platelet Number or Function Program: Oral and Poster Abstracts Session: 311. Disorders of Platelet Number or Function: Poster II 1* 2* 3* Matthieu Mahevas, MD, PhD , Sandrine Van Eeckhoudt, MD , Guillaume Moulis, MD, PhD , Christine 4* 5* 6* 7* 8* Dosquet, MD, PhD , Marc Michel, MD, PhD , Nicolas Limal, MD , Laetitia Languille , Sawsaneh Alkaeir, MD , 9* 10* 11* 12* Philippe Bierling, MD, PhD , Antoine Dossier, MD , Frédéric Duriez, MD , Lionel Galicier, MD , Anne-Sophie 13* 14* 15* 16* Morin, M.D , Jérôme Tamburini, MD, PhD , Driss Chaoui, MD , Didier Bouscary, MD, PhD , Ahmad AL 17* 18* 19* 20* Jijakli, MD , Mehdi Khellaf, MD , Ioana Vaida, MD , Bertrand Godeau, MD, PhD and Christine 21 Chomienne, MD, PhD 1 Internal Medicine, French referral center for adult's immune cytopenia, Henri Mondor Hospital, AP-HP, UPEC University, Créteil, France 2 Internal Medicine., French Referral Center for Adult's Immune Cytopenia. Henri Mondor. AP-HP. UPEC University., Créteil, France 3 CIC 1436, Toulouse University Hospital, Toulouse, France 4 Service de Biologie Cellulaire, Assistance Publique des Hôpitaux de Paris (AP-HP), Hôpital Saint Louis, INSERM UMR_S1131, Institut Universitaire d'Hématologie, Paris, France, Paris, France 5 Henri Mondor Hospital, Assistance Publique Hopitaux de Paris, Paris XII universi, Creteil, FRA 6 Internal Medicine., French Referral Center for Adult's Immune Cytopenia. Henri Mondor Hospital. AP-HP. UPEC University., Créteil, France 7 French Referral center for Audlt's Immune Cytopenia. henri Mondor Hospital. UPEC University., Créteil, France 8 UMRS-1131, INSERM Hôpital Saint Louis, Paris, France 9 Internal Medicine, French Referral center for Adult's Immune Cytopenia. Henri Mondor Hospital. AP-HP. UPEC University, Créteil, France 10 Department of internal Medicine, Hôpital Bichat, Paris, France Oncology - Hematology, Les Hôpitaux de Chartres., Chartres, France 12 St-Louis University Hospital, Paris, France 13 Department of Internal Medicine, Hopital Jean Verdier, Bondy, France 14 Service d'Hématologie Clinique, Hôpital Cochin, Paris, France 15 Hematology, CH Victor Dupouy, Argenteuil, France 16 Hematology Department, Cochin University Hospital, AP-HP, Paris, France 17 CH Argenteuil, Argenteuil, France 18 Henri Mondor Hospital, AP-HP, UPEC University, Creteil, France 19 Hematology, CH Pontoise, Pontoise, France 20 Internal Medicine, French Referral Center for Adult's Immune Cytopenia. Henri Mondor Hospital. AP-HP. UPEC University., Créteil, France 21 UMRS-1131, INSERM Hopital Saint-Louis, Paris, France 11 3485 Reduced-Intensity and Non-Myeloablative Allogeneic Stem Cell Transplantation from Alternative HLAMismatched Donors for Hodgkin’s Lymphoma: A Study By the SFGM-TC (Francophone Society of Bone Marrow Transplantation and Cellular Therapy) Clinical Allogeneic Transplantation: Results Program: Oral and Poster Abstracts Session: 732. Clinical Allogeneic Transplantation: Results: Poster II 1* 2* 3* 4* Jordan Gauthier, MD , Luca Castagna, MD , Federico Garnier, MD , Thierry Guillaume, MD, PhD , Gerard 5 6* 7* 8 Socie, MD, PhD , Sebastien Maury, MD, PhD , Natacha Maillard, MD , Reza Tabrizi, MD , Tony Marchand, 9* 10* 11* 12 13* MD , Jean Valere Malfuson , Anne-Claire Gac, MD , Emmanuel Gyan, MD, PhD , Melanie Mercier, MD , 14 15* 16* 17* Yves Beguin, MD, PhD , Jeremy Delage, MD , Pascal Turlure, MD , Ambroise Marçais, MD , Stephanie 18* 19* 20* 21* Nguyen, MD, PhD , Remy Dulery, MD , Jacques Olivier Bay, MD , Anne Huynh, MD , Etienne Daguindau, 22* 23* 24 25* MD , Caroline Régny , Mauricette Michallet, MD, PhD , Regis Peffault De La Tour, MD, PhD , Ibrahim 26 27 Yakoub-Agha, MD, PhD and Didier Blaise, MD, PhD 1 CHRU Lille Hopital Huriez, Lille, France 2 Oncology and Hematology, Humanitas Cancer Center, Humanitas Clinical and Research Center, Rozzano, Italy 3 agence de la biomédecine, Saint Denis, France 4 Department of Hematology, Nantes University Hospital, Nantes, France 5 St-Louis Hospital, Paris, France 6 Hopital Henri Mondor, Creteil, FRA 7 Bone Marrow Transplant Unit Clinical Hematology, Hopital La Miletrie, Poitiers, France 8 Hematology, University Hospital of Bordeaux, Pessac, France 9 Department of Hematology, Centre Hospitalier Universitaire de Rennes, Rennes, France 10 Hôpital d'instruction des armées Percy, Paris Cedex 10, FRA 11 CHU Caen, Caen, France 12 Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France 13 Haematology, CHU Angers, Angers, France 14 Hematology, University and CHU of Liege, Liege, Belgium 15 CHU Lapeyronie, Département d`Hématologie Clinique, Montpellier, FRA 16 Hematology, CHU Limoges, Limoges, France 17 Service d’hématologie and Imagine Institute, Necker Hospital, Paris, France 18 Department of hematology, Pitie Salpetriere Hospital, Paris, France 19 Hematology and Cellular Therapy, Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France 20 Hematology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France 21 Institut Universitaire du Cancer, Oncopole IUCT, Toulouse, France 22 Hematology Department, Besançon University Department, Besançon, France 23 Department of Hematology, University CHU Grenoble, Grenoble, France 24 Department of Hematology, Centre Hospitalier Lyon-Sud, Lyon, France 25 Hematology - Bone Marrow Transplantation, Hopital St Louis, Paris, France 26 Hematology, Hôpital HURIEZ UAM allogreffe de CSH, CHRU, Lille, France 27 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 903 Durable Overall Survival Benefit in Patients ≥ 60 Years with Relapsed or Refractory AML Treated with Vosaroxin/Cytarabine Vs Placebo/Cytarabine: Updated Results from the Valor Trial Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Clinical Trials of Novel Drugs and Combinations in AML 1 2 3* 4 5 Farhad Ravandi, MD , Ellen K. Ritchie, MD , Hamid Sayar, MD , Jeffrey E. Lancet, MD , Michael Craig, MD , 6 7 8 9 Norbert Vey, MD, PhD , Stephen A. Strickland , Gary J. Schiller, MD , Elias J. Jabbour, MD , Harry P. Erba, MD, 10 11* 12 13 PhD , Arnaud Pigneux, MD , Heinz-August Horst, MD, PhD , Christian Recher, MD, PhD , Virginia M. Klimek, 14 15 16 17 17* MD , Jorge E. Cortes, MD , Gail J. Roboz , Adam R. Craig, MD, PhD , Renee Ward, MD, PhD , Jennifer Smith, 17* 18 19 PhD , Hagop M. Kantarjian, MD and Robert K. Stuart, MD 1 University of Texas MD Anderson Cancer Center, Houston, TX 2 Weill Cornell Medical Center, New York, NY 3 Indiana University Cancer Center, Indianapolis, IN 4 Moffitt Cancer Center, University of South Florida, Tampa, FL 5 West Virginia University, Morgantown, WV 6 Institut Paoli-Calmettes, Marseille, France 7 Vanderbilt-Ingram Cancer Center, Nashville, TN 8 University of California Los Angeles, Los Angeles, CA 9 Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 10 Division of Hematology and Oncology, University of Alabama, Birmingham, AL 11 Hôpital Haut Lévêque-CHU de Bordeaux, Pessac Cedex, France 12 II. Medizinische Klinik und Poliklinik im Städtischen Krankenhaus, Kiel, Germany 13 Hôpital Purpan-CHU de Toulouse, Toulouse, France 14 303 East 60th Street Apt 27I, Memorial Sloan Kettering Cancer Center, New York City, NY 15 University of Texas M.D. Anderson Cancer Center, Houston, TX 16 Division of Hematology and Oncology, Weill Cornell Medicine and The New York Presbyterian Hospital, New York, NY 17 Sunesis Pharmaceuticals, Inc., South San Francisco, CA 18 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 19 Hollings Cancer Center, Medical University of South Carolina, Charleston, SC 4637 Extending Autologous Hematopoietic Stem Cell Transplantation As First Line Treatment in Multiple Myeloma Patients with Severe Renal Impairment: A Retrospective Study of the Francophone Society of Stem Cell Transplantation and Cellular Therapy (SFGM-TC) Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Session: 731. Clinical Autologous Transplantation: Results: Poster III 1* 2* 3 4* 5* Karine Augeul-Meunier, MD , Denis Caillot , Anne-Marie Stoppa , Lionel Karlin, MD , Lofti Benboubker , 6* 7 8* Natacha Maillard, MD , Mohamad Mohty, MD, PhD , Ibrahim Yakoub-Agha, MD , Jacques-Olivier Bay, MD, 9 10* 11* 12* 13* PhD , Caroline Bonmati, MD , Claude-Eric Bulabois, MD , Anne Huynh, MD , Melanie Mercier, MD , 14* 15* 1* Laurent Frenzel, MD, PhD , Hervé Avet-Loiseau and Jerome Cornillon, MD 1 Hematology department, Institut de Cancerologie Lucien Neuwirth, Saint-Priest-en-Jarez, France 2 Hématologie Clinique, Dijon University Hospital, Dijon, France 3 Institut Paoli Calmettes, Marseille, France 4 Service d'Hématologie, Centre Hospitalier Lyon Sud, Pierre Bénite, France 5 CHU Tours Hopital Bretonneau, Tours, France 6 Bone Marrow Transplant Unit Clinical Hematology, Hopital La Miletrie, Poitiers, France 7 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 8 Hematology, Lille, France 9 Hematology department, CHU Clermont Ferrand, Clermont Ferrand, France 10 Hematology, CHU Nancy, Nancy, France 11 Hematology, CHU Grenoble, Grenoble, France 12 Institut Universitaire du Cancer Toulouse, Oncopole, Toulouse, France 13 Haematology, CHU Angers, Angers, France Department of Clinical Hematology, Hopital Necker, AP-HP, Paris, France 15 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 14 1162 Prospective Phase II Study of Prophylactic Azacitidine and Donor Lymphocyte Infusions Following Allogeneic Hematopoietic Stem Cell Transplantation for High Risk Acute Myeloid Leukemia and Myelodysplastic Syndrome Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence Program: Oral and Poster Abstracts Type: Oral Session: 723. Clinical Allogeneic and Autologous Transplantation: Late Complications and Approaches to Disease Recurrence: Immunotherapy to Prevent or Treat Relapse After Transplantation 1* 2 3 4* Thierry Guillaume, MD, PhD , Ibrahim Yakoub-Agha, M.D.- PhD , Reza Tabrizi, MD , Cecile Borel, MD , Patrice 1* 2* 5* 1* Chevallier, MD, PhD , Leonardo Magro, MD , Stéphane Vigouroux, MD , Pierre Peterlin, MD , Alice Garnier, 1* 6* 7* 8 1* MD , Marie-Thérèse Rubio, MD, PhD , Anne Huynh, MD , Noel Milpied, MD PhD , Philippe Moreau and 9 Mohamad Mohty, MD, PhD 1 Department of Hematology, Nantes University Hospital, Nantes, France 2 Hematological department, Lille University Hospital, Lille, France 3 Hematology, University Hospital of Bordeaux, Pessac, France 4 Hematology, Toulouse University Hospital, Toulouse, France 5 University Hospital of Bordeaux, Bordeaux, France 6 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 7 Department Hématologie, Hôpital de Purpan, Toulouse, France 8 Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Leveque and University of Bordeaux, Bordeaux, France 9 Hematology, Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France 145 Rituximab Maintenance after Autologous Stem Cell Transplantation Prolongs Survival in Younger Patients with Mantle Cell Lymphoma: Final Results of the Randomized Phase 3 LyMa Trial of the Lysa/Goelams Group Mantle Cell, Follicular, and Other Indolent B-Cell Lymphoma—Clinical Studies Program: Oral and Poster Abstracts Type: Oral Session: 623. Mantle Cell, Follicular, and Other Indolent B-Cell Lymphoma—Clinical Studies: Therapeutic Approaches to Mantle Cell Lymphoma 1,2* 3 4* 5* Steven Le Gouill, MD, PhD , Catherine Thieblemont, MD, PhD , Lucie Oberic, MD , Anne Moreau, MD , 6* 7 8* 9 Krimo Bouabdallah, MD , Emmanuel Gyan, MD, PhD , Gandhi Damaj , Vincent Ribrag, MD , Pierre Feugier, 10* 11* 12* 13 MD, PhD , Olivier Casasnovas, MD , Hacene Zerazhi, MD , Corinne Haioun, MD, PhD , Hervé Tilly, MD, 14 15* 16* 17 PhD , Olivier Tournilhac, MD, PhD , Herve Maisonneuve, MD , Philippe Solal-Celigny, MD , Luc Mathieu 18* 19 20 21 Fornecker, MD, PhD , Eric W Van Den Neste, MD, PhD , Danielle Canioni, MD , Gilles Salles, MD, PhD , 22 23* 24 25* Thierry Lamy, MD PhD , Marie-Christine Bene, PharmD , Remy Gressin, MD and Olivier Hermine, MD, PhD 1 Department of hematology, Nantes university Hospital and UMR892 INSERM, Nantes, France 2 CHU de Nantes, INSERM UMR 892 équipe 10, Nantes, France 3 Hôpital Saint-Louis, Paris, France 4 Department of Hematology, Purpan University Hospital, Toulouse, France 5 Department of Pathology, Nantes University Hospital, Nantes, France 6 Haematology, CHU de Bordeaux, Bordeaux, France 7 Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France 8 CHU d'Amiens, Amiens, France 9 Gustave Roussy cancer campus, Villejuif, France 10 CHU et INSERM 954, Nancy Université, Vandoeuvre Les Nancy, France 11 Hematology Department, Hopital Le Bocage, CHU Dijon, Dijon, France 12 hematology, CHG Avignon, Avignon, France 13 Lymphoid Malignancies Unit, AP-HP, Groupe Hospitalier Mondor, Créteil, France INSERM U918, Centre Henri Becquerel, Rouen, France 15 Service d'Hematologie Clinique et de Therapie Cellulaire, CHU, Universite d'Auvergne, EA7283, CIC501, Clermont-Ferrand, Clermont Ferrand, France 16 Oncology and Hematology Department, CH, La Roche-sur-Yon, France 17 Centre Jean Bernard, Le Mans, France 18 Haematology, University Hospital, Strasbourg, France 19 Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium 20 Pathology Department, Hopital Necker, Paris, France 21 Hematologie, Hospices Civils de Lyon - Université de Lyon - UMR CNRS5239, Pierre-Benite, France 22 INSERM U917, CHU Pontchaillou, Rennes, France 23 Hopital Hotel Dieu, Laboratoire d'Hematologie, Nantes, France 24 Hematology, CHU Grenoble, Grenoble, France 25 Hematology Department, Necker University Hospital, AP-HP, Paris, France 14 3467 Characterization of Factors Determining the Kinetics of Disease Relapse after Allogeneic Stem Cell Transplantation (allo-SCT) or Chemotherapeutic Consolidation for Acute Myeloid Leukaemia (AML) in First CR: A Survey from HOVON-SAKK and the Acute Leukaemia Working Party of the EBMT Clinical Allogeneic Transplantation: Results Program: Oral and Poster Abstracts Session: 732. Clinical Allogeneic Transplantation: Results: Poster II 1 2* 3* 4 5* Charles Craddock, MD, PhD , Jurjen Versluis , Myriam Labopin , Gerard Socie , Anne Huyn , Eric Deconinck, 6 7 8 9* 10 MD, PhD , Liisa Volin, MD, PhD , Noel Milpied, MD , Jean Henri Bourhis, MD, PhD , Alessandro Rambaldi, MD , 11* 12 13* 14 Patrice Chevallier, MD, PhD , Didier Blaise, MD, PhD , Manz Markus , Edo Vellenga, MD, PhD , Marie 15* 16* 17 18* Christiane Vekemans , Johan Maertens, MD, PhD , Jakob R. Passweg , Christoph Schmid , G J. 19 20 21 22 Ossenkoppele , Paresh Vyas, MD, PhD , Bob Löwenberg, MD, PhD , Mohamad Mohty, MD, PhD , Jan J. 23 24 Cornelissen, MD, PhD and Arnon Nagler, MD, MSc 1 Centre for Clinical Haematology, Queen Elizabeth Hospital, Birmingham, United Kingdom 2 Erasmus University Medical Center, Rotterdam, Netherlands 3 Department of Hematology and Cell Therapy, Saint Antoine Hospital, Paris, France 4 Department of Hematology - BMT, Hopital St. Louis, Paris, France 5 Institut Universitaire Du Cancer, Toulouse, France 6 Hematology, INSERM UMR1098 - CHU Jean Minjoz, Besancon, France 7 Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland 8 Service d’Hematologie Clinique et Therapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France 9 Gustave Roussy Cancer Center, Villejuif, France 10 Hematology and Bone Marrow Transplant Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy 11 Department of Hematology, Nantes University Hospital, Nantes, France 12 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 13 University of Zurich, Zurich, Switzerland 14 Department of Experimental Hematology, Cancer Research Center Groningen, University Medical Center Groningen, University Groningen, Groningen, Netherlands 15 University, Bruxelles, BEL 16 Department of Hematology, University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium 17 for the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation, (SAA WP-EBMT), Switzerland 18 2. Medizinische Klinik, Klinikum Augsburg, Augsburg, Germany 19 Department of Hematology, VU University Medical Center, Amsterdam, Netherlands 20 MRC Molecular Haematology Unit, Weatherall Institute of Molecular Medicine and Department of Haematology, University of Oxford, Oxford, United Kingdom 21 Editor-in-Chief, Blood, Erasmus University Medical Center, Rotterdam, Netherlands 22 Department of Haematology, EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 23 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands 24 Division of Hematology, Sheba Medical Center, Ramat Gan, Israel 238 A Novel Evolutionary Pattern Revealed Using Deep Sequencing of Immunoglobulin Loci at Diagnosis and over the Course of Treatment in Multiple Myeloma Patients Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Progression 1 2* 3* 4* Nikhil C. Munshi, MD , Joaquin Martinez-Lopez , Victoria Carlton, Ph.D. , Stephanie Minvielle , Yu-Tzu Tai, 5 6 6* 7 8 PhD , Mariateresa Fulciniti, PhD , Mehmet K. Samur, PhD , Paul G. Richardson, MD , Michel Attal , Philippe 9* 4* 10 3 Moreau , Florence Magrangeas , Kenneth C. Anderson, MD , Malek Faham, MD, PhD and Hervé Avet11* Loiseau 1 The Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 2 Hospital-12-de-Octubre, Madrid, Spain 3 Adaptive Biotechnologies Corp, South San Francisco, CA 4 Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France 5 Harvard Medical School, the Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Boston, MA 6 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 7 Division of Hematologic Malignancy, Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 8 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 9 Department of Hematology, Nantes University Hospital, Nantes, France 10 Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 11 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 116 Analysis of Mutational Signatures Suggest That Aid Has an Early and Driver Role in Multiple Myeloma Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Biologic Insights from Genetics 1,2,3* 1,2,3* 4* 3* 5* Francesco Maura , Niccolo Bolli, MD , Stephane Minvielle , Dominik Gloznik , Raphael Szalat , Anthony 3* 3* 6* 3* 3* Fullam , Inigo Martincorena , Mehmet Kemal Samur, PhD , Patrick Tarpey , Helen Davies , Kevin J. 3* 3* 7* 3* 8* 9* Dawson , Serena Nik-Zainal , Moritz Gerstung , Jorge Zamora , Yu-Tsu Tai , Cristiana Carniti , Florence 10* 10* 1,2 8* 3,11* Magrangeas , Philippe Moreau , Paolo Corradini , Kenneth Anderson , David Wedge , Hervé Avet4* 3* 8,12 Loiseau , Peter Campbell and Nikhil Munshi 1 Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 2 Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy 3 Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom 4 Centre Hospitalier Universitaire Rangueil, Unité de Genomique du Myelome, Toulouse, France 5 Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 6 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 7 European Bioinformatics Institute, European Molecular Biology Laboratory (EMBL-EBI), Hinxton, United Kingdom 8 Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 9 Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milano, Milan, Italy 10 Université de Nantes, INSERM UMR 892, CNRS UMR 6299, Nantes, France 11 University of Oxford, Big Data Institute, Oxford, United Kingdom 12 Boston Veterans Administration Healthcare System, West Roxbury, MA 243 Higher c-MYC Expression Is Associated with Ixazomib-Lenalidomide-Dexamethasone (IRd) ProgressionFree Survival (PFS) Benefit Versus Placebo-Rd: Biomarker Analysis of the Phase 3 Tourmaline-MM1 Study in Relapsed/Refractory Multiple Myeloma (RRMM) Myeloma: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Type: Oral Session: 653. Myeloma: Therapy, excluding Transplantation: Clinical Studies, Minimal Residual Disease, and Biomarkers 1* 2,3 4 5* Alessandra Di Bacco, PhD , Nizar J. Bahlis, MD , Nikhil C Munshi, MD , Hervé Avet-Loiseau , Tamás Masszi, 6* 7* 8* 9* 10* MD , Luísa Viterbo, MD , Ludek Pour, MD, PhD , Peter Ganly, BMBCh, PhD , Michele Cavo, MD , Christian 11 12 12 1 1* Langer, MD , Shaji Kumar, MD , S. Vincent Rajkumar, MD , Deborah Berg, RN, MSN , Jianchang Lin, PhD , 1* 1* 1* 1* 1* 1 Bin Li , Sunita Badola , Lei Shen , Jacob Zhang , Ling Wang, PhD , Dixie-Lee Esseltine, MD , Katarina 1 1* 13 14* Luptakova , Helgi van de Velde, MD, PhD , Paul G. Richardson, MD and Philippe Moreau 1 Millennium Pharmaceuticals Inc., a wholly owned subsidiary of Takeda Pharmaceutical Company Limited, Cambridge, MA 2 University of Calgary, Arnie Charbonneau Cancer Institute, Calgary, AB, Canada 3 University of Calgary, Calgary, AB, Canada 4 Hematologic Oncology, Dana-Farber Cancer Institute, Boston, MA 5 Hematology, IUC-Oncopole, Toulouse, France 6 Department of Haematology and Stem Cell Transplantation, St. Istvan and St. Laszlo Hospital of Budapest, Budapest, Hungary 7 Instituto Português de Oncologia do Porto Francisco Gentil, Entidade Pública Empresarial (IPOPFG, EPE), Porto, Portugal 8 Hematology and Oncology, University Hospital Brno, Brno, Czech Republic 9 Department of Haematology, Christchurch Hospital, Christchurch, New Zealand 10 Seràgnoli Institute of Hematology, University of Bologna, Bologna, Italy 11 University Hospital of Ulm, Ulm, Germany 12 Division of Hematology, Mayo Clinic, Rochester, MN 13 Dana-Farber Cancer Institute, Boston, MA 14 Hematology, University Hospital Hôtel Dieu, Nantes, France 3186 Impact of Treatment with Iron Chelators in Lower-Risk MDS Patients Participating in the European Leukemianet MDS (EUMDS) Registry Myelodysplastic Syndromes—Clinical Studies Program: Oral and Poster Abstracts Session: 637. Myelodysplastic Syndromes—Clinical Studies: Poster II 1,2* 3* 4* 4* 4* Saskia Langemeijer, MD, PhD , Louise De Swart, MD , Ge Yu, MSc. , Alex Smith , Simon Crouch, PhD , Tom 5* 6 7 8 Johnston, PhD , Pierre Fenaux, MD, PhD , Argiris Symeonidis , Jaroslav Cermak , Eva Hellstrom-Lindberg, MD, 9 10 11* 12 13* PhD , Guillermo Sanz, MD , Reinhard Stauder, MD , Luca Malcovati, MD , Ulrich Germing , Mette Skov 14* 15 16* 17* Holm , Moshe Mittelman, MD , Krzysztof Madry, MD, PhD , Aurelia Tatic, MD , Antonio Almeida, MD, 18* 19 20 21* 22 PhD , Aleksandar Savic , Sophie Park, MD, PhD , Odile Beyne-Rauzy, MD , Raphaël Itzykson, MD, PhD , 3* 23* 24 Corine van Marrewijk, Ph.D. , David Bowen, MD, PhD and Theo de Witte, MD, PhD 1 Radboud University medical Center, Nijmegen, Netherlands Radboudumc, Nijmegen, Netherlands 3 Hematology, Radboudumc, Nijmegen, Netherlands 4 Epidemiology and Cancer Statistics Group, University of York, York, United Kingdom 5 University of York, York, United Kingdom 6 Service d'Hématologie Séniors, Hôpital Saint-Louis, Université Paris 7, Paris, France 7 Department of Internal Medicine, Division of Hematology, University of Patras Medical School, Patras, Greece 8 Institute of Hematology and Blood Transfusion, Prague, Czech Republic 9 Center for Hematology and Regenerative Medicine (HERM), Department of Medicine, Karolinska Institutet, Stockholm, Sweden 10 Hematology Department, Hospital Universitari i Politècnic La Fe, Valencia, Spain 2 11 Department of Internal Medicine V (Hematology and Oncology), Innsbruck Medical University, Innsbruck, Austria 12 Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Pavia, Italy 13 Department of Hematology, Oncology, and Clinical Immunology, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany 14 Dept of Hematology, Aarhus University Hospital, Aarhus, Denmark 15 Tel Aviv Sourasky Medical Center, Tel Aviv, Israel 16 Department of Hematology, Oncology and Internal Diseases, Medical University of Warsaw, Warsaw, Poland 17 Center of Hematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania 18 Serviço de Hematologia, Lisbon, Portugal 19 Clinic of Hematology, Clinical Center of Vojvodina, Novi Sad, Serbia 20 Cochin Hospital, University Paris 5, Paris, France 21 Service d’hématologie, Centre Hospitalier Universitaire de Purpan, Toulouse, France 22 UMR7212/U944, Institut National de la Santé et de la Recherche Médicale, Saint-Louis Institute, University Paris 7, Paris, France 23 St James's Institute of Oncology, Leeds, United Kingdom 24 Nijmegen Center for Molecular Life Sciences, Dep. of Tumor Immunology, Radboud University of Nijmegen Medical Centre, Nijmegen, Netherlands 2776 Prevention of Venous Thrombotic Events in Adult Patients with Acute Lymphoblastic Leukemia Treated in a Pediatric-Inspired Protocol – a Graall Study Acute Lymphoblastic Leukemia: Clinical Studies Program: Oral and Poster Abstracts Session: 612. Acute Lymphoblastic Leukemia: Clinical Studies: Poster II 1* 2* 3* 4* Corentin Orvain , Marie Balsat, MD , Véronique Lhéritier , Emmanuelle Tavernier , Jean-Pierre Marolleau, 5* 6,7 8* 9* MD, PhD , Thomas Pabst, MD, PhD , Patrice Chevallier, MD, PhD , Noémie De Gunzburg, MD , Victoria 10* 11* 12* 13* 6,14 Cacheux , Francoise Huguet, MD , Sylvain Chantepie, MD , Denis Caillot , Yves Chalandon, MD , Jamilé 15* 16* 17 17 Frayfer, MD , Caroline Bonmati, MD , Nicolas Boissel, MD, PhD , Hervé Dombret, MD, PhD , Norbert 18 1* Ifrah and Mathilde Hunault-Berger, MD, PhD 1 Maladies du Sang, Angers University Hospital, Angers, France 2 Hématologie Clinique, Lyon-Sud Hospital, Pierre Benite, France 3 GRAALL Coordination, Lyon-Sud University Hospital, Pierre-Bénite, France 4 Hematology, Lucien Neuwirth Cancer Institute, Saint-Priest-en-Jarez, France 5 Hématologie Clinique, Amiens University Hospital, Amiens, France 6 Swiss Group for Clinical Cancer Research (SAKK), Bern, Switzerland 7 Department of Hematology, Bern University Hospital, Bern, Switzerland 8 Department of Hematology, Nantes University Hospital, Nantes, France 9 Hématologie Oncologie, Versailles Hospital, Versailles, France 10 Hematology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France 11 Hématologie, Toulouse Cancer University Institute, Toulouse, France 12 Institut d'Hématologie, Caen University Hospital, Caen, France 13 Hématologie Clinique, Dijon University Hospital, Dijon, France 14 Division of Hematology, Geneva University Hospitals, Geneva, Switzerland 15 Hématologie, Meaux Hospital, Meaux, France 16 Hématologie, Nancy University Hospital, Nancy, France 17 Hématologie Adulte, Saint-Louis Hospital, APHP, Paris, France 18 Hematology, Angers University Hospital, Angers, France 3271 Multiple Myeloma with a Deletion of Chromosome 17p: TP53 Mutations Are Highly Prevalent and Negatively Affect Prognosis Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster II 1* 1* 1* Davine Hofste op Bruinink, MD, MSc , Hoogenboezem Remco, MSc , Mathijs A. Sanders, PhD , Christopher P 2* 2* 3* 1* Wardell, PhD , Cody Ashby, PhD , Eric M.J. Bindels, PhD , Claudia Erpelinck-Verschueren, BSc , Paulette van 1* 1* 3* 4* 4* Strien, BSc , Jasper Koenders, BSc , François G. Kavelaars, BSc , Jie He, PhD , Mark Bailey, MSc , Tariq I 4 5* 6* 7* 1 Mughal, MD, FRCP , Kristine Misund, PhD , Berna Beverloo, PhD , Bronno van der Holt, PhD , Ivo Touw, PhD , 5 8* 9 2 Anders Waage, MD PhD , Hervé Avet-Loiseau , Graham H Jackson, MD, PhD , Gareth J Morgan, MD, PhD , 2 1 Brian A Walker, PhD and Pieter Sonneveld, MD PhD 1 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands 2 Myeloma Institute, University of Arkansas for Medical Sciences, Little Rock, AR 3 Department of Hematology, Erasmus University Medical Center, Rotterdam, Netherlands 4 Foundation Medicine, Inc., Cambridge, MA 5 KG Jebsen Center for Myeloma Research, Norwegian University of Science and Technology, Trondheim, Norway 6 Department of Clinical Genetics, Erasmus MC, Rotterdam, Netherlands 7 Department of Hematology, Erasmus MC Cancer Institute, HOVON Data Center, Rotterdam, Netherlands 8 IUC-Oncopole, Unité de Génomique du Myélome, Toulouse, France 9 Northern Institute for Cancer Research, Newcastle University, Newcastle upon Tyne, United Kingdom 1816 Clinical Spectrum, Evolution and Management of Autoimmune Cytopenia Associated with Angioimmunoblastic T-Cell Lymphoma: A Retrospective, Multicenter Study Hodgkin Lymphoma and T/NK Cell Lymphoma—Clinical Studies Program: Oral and Poster Abstracts Session: 624. Hodgkin Lymphoma and T/NK Cell Lymphoma—Clinical Studies: Poster I 1* 2* 3* 4* Etienne Crickx, MD , Radjiv Goulabchand, MD , Claire Fieschi, MD, PhD , Lionel Galicier, MD , Paul Coppo, 5* 6* 7 8* MD, PhD , Veronique Meignin, MD , Richard Delarue, MD , Olivier Casasnovas, MD , Veronique Leblond, MD, 9* 10* 11* 12* 13* PhD , Guillaume Moulis, MD, PhD , Marc Michel, MD, PhD , Jehan Dupuis, MD , Fabien Le Bras, MD , 14* 15 11* Virginie Fataccioli, PhD , Corinne Haioun, MD, PhD , Bertrand Godeau, MD, PhD , Philippe Gaulard, MD, 16* 11* PhD and Matthieu Mahevas, MD, PhD 1 Service de Médecine interne, Hôpital Henri Mondor, Créteil, France 2 Service de Médecine interne, Hôpital Saint Eloi, Montpellier, France 3 Service d'immunologie clinique, Hôpital Saint Louis, Paris, France 4 St-Louis University Hospital, Paris, France 5 Hematology and Cellular Therapy, Saint Antoine Hospital, Paris, France 6 Pathology, APHP, Hopital Saint-Louis, Paris, France 7 Hematology Department, Necker University Hospital, AP-HP, Paris, France 8 Hematology Department, Hopital Le Bocage, CHU Dijon, Dijon, France 9 Department of Haematology, Hôpital de la Pitié-Salpétrière, Paris, France 10 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France 11 Internal Medicine, French referral center for adult's immune cytopenia, Henri Mondor Hospital, AP-HP, UPEC University, Créteil, France 12 Lymphoid Malignancies Unit, APHP, Groupe Hospitalier Mondor, CRETEIL, France 13 Service d'Hématologie Lymphoide, Hôpital Henri Mondor, Créteil, France 14 Inserm U955, APHP Hospital Henri Mondor, Creteil, France 15 Lymphoid Malignancies Unit, AP-HP, Groupe Hospitalier Mondor, Créteil, France 16 department of pathology, APHP, Groupe Hospitalier Mondor, CRETEIL, France 2088 Whole Genome Sequencing of Unique Paired SMM/MGUS Progressing to MM Samples Reveals a Genomic Landscape with Diverse Evolutionary Pattern Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I 1,2,3* 1,2,3* 4* 1* 5* Niccolo Bolli, MD , Francesco Maura , Stephane Minvielle , Dominik Gloznik , Raphael Szalat , Anthony 1* 6* 1* 1* 1* Fullam , Mehmet Kemal Samur, PhD , Patrick Tarpey , Helen Davies , Inigo Martincorena , Kevin J. 1* 1* 1* 7* 8* 9* Dawson , Thomas Mitchell , Jorge Zamora , Cristiana Carniti , Yu-Tsu Tai , Florence Magrangeas , Philippe 9* 2,3* 8* 1,10* 4* Moreau , Paolo Corradini , Kenneth Carl Anderson , David Wedge , Hervé Avet-Loiseau , Peter 1* 11,12 Campbell and Nikhil Munshi, MD 1 Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy 3 Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 4 Centre Hospitalier Universitaire Rangueil, Unité de Genomique du Myelome, Toulouse, France 5 Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 6 Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 7 Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori and University of Milano, Milan, Italy 8 Jerome Lipper Multiple Myeloma Center, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 9 Université de Nantes, INSERM UMR 892, CNRS UMR 6299, Nantes, France 10 University of Oxford, Big Data Institute, Oxford, United Kingdom 11 Dana–Farber Cancer Institute, Medical Oncology, Harvard Medical School, Boston, MA 12 Boston Veterans Administration Healthcare System, West Roxbury, MA 2 3458 Outcome Analysis of High-Dose Chemotherapy Followed By Autologous Stem Cell Transplantation in Patients with Hodgkin Lymphoma: A Francophone Society of Bone Marrow Transplantation and Cellular Therapy Study Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Session: 731. Clinical Autologous Transplantation: Results: Poster II 1* 2 3* 4 5 Remy Dulery, MD , Oumedaly Reman, MD , Ariane Boumemdil , Reda Bouabdallah, MD , Pauline Brice, MD , 6* 7 8 9* 10 Thomas Gastinne, MD , Reza Tabrizi, MD , Philippe Quittet, MD , Anne Huynh, MD , Gilles Salles, MD, PhD , 11* 12* 13 14* Helene Monjanel , Aspasia Stamatoullas, MD , Jean-Henri Bourhis, MD, PhD , Caroline Bonmati, MD , 15* 16* 17* 18 Sylvie Francois, MD , Stephanie Nguyen Quoc, MD PhD , Jacques Olivier Bay, MD , Jean-Yves Cahn, MD , 19* 20* 1 Pascal Turlure, MD , Charles Dauriac, MD , Mohamad Mohty, MD, PhD , Regis Peffault De Latour, MD, 21* 22 PhD and Ibrahim Yakoub-Agha, MD, PhD 1 Hematology and Cellular Therapy, Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France 2 Hematology, CHU Caen, Caen, France 3 Biostatistics, EBMT LWP Office, Paris, France 4 Hematology, Institut Paoli-Calmettes, Marseille, France 5 Hematology, AP-HP Hopital Saint-Louis, Paris, France 6 Hematology, CHU Nantes, Nantes, France 7 Hematology, University Hospital of Bordeaux, Pessac, France 8 Hematology, CHU Saint Eloi Montpellier, Montpellier, France 9 Institut Universitaire du cancer, Oncopole IUCT, Toulouse, France 10 Hematology, Hospices Civils de Lyon - Université de Lyon, Pierre-Bénite, France 11 Hematology, CHU Tours, Tours, France 12 Clinical Hematology, Centre Henri Becquerel, Rouen, France 13 Division of Hematology, Institut Gustave Roussy, Villejuif, France 14 Hematology, CHU Nancy, Nancy, France 15 Hematology, CHU Angers, Angers, France 16 Hematology Department, Pitie-Salpetriere Hospital, Paris, France 17 Hematology, Clermont-Ferrand University Hospital, Clermont-Ferrand, France 18 Hematology, CHU Grenoble Alpes, Grenoble, France 19 Hematology, CHU Limoges, Limoges, France 20 Hematology, CHU Rennes, Rennes, France 21 Hematology - Bone Marrow Transplantation, Saint Louis Hospital, Paris, France 22 Service des Maladies du Sang, Hopital Claude Huriez, CHRU Lille, Lille, France 2861 Mutational Analysis of MDS and AML Occurring after Treatment for Acute Promyelocytic Leukemia (APL). a Report of 9 Cases Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis Program: Oral and Poster Abstracts Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster II 1* 2* 3 4* 5* Philippe Attias , Aline Renneville, MD , Xavier Thomas, MD, PhD , Cecile Bally , Sandrine Hayette , Hassan 6* 7* 8* 9* Farhat, MD , Virginie Eclache, MD , Alice Marceau , Bruno Cassinat, PharmD, PhD , Jean Feuillard, MD- PhD, 10* 11* 12* 13* 14* Pr , Christine Terré, PharmD, PhD , Eric Delabesse, PharmD, PhD , Sophie Park, MD, PhD , Julie Lejeune , 15* 16 2 Sylvie Chevret, MD, PhD , Lionel Ades, MD, PhD , Claude Preudhomme, MD, PhD and Pierre Fenaux, MD, 17,18 PhD 1 Service d'Hématologie Senior, Hôpital Saint Louis, Paris, France 2 Hematology Laboratory, CHRU Lille, Lille, France 3 CHU, Lyon, France 4 Hopital Saint Louis, Paris, France 5 Laboratory of Hematology, Centre Hospitalier Lyon-Sud, Lyon, France 6 Hematology Department, CH Versailles, Versailles, France 7 Hematology Laboratory, CHU Avicenne, Bobigny, France 8 Haematology Laboratory, CHRU Lille, Lille, France 9 Service de Biologie Cellulaire, AP-HP, Hôpital Saint-Louis, Paris, France 10 Laboratoire d'hématologie, CHU Limoges, Limoges, France 11 Hematology Laboratory, Centre Hospitalier Andre Mignot, Versailles, France 12 Laboratoire d'Hématologie, CHU de Toulouse, Toulouse, France 13 CHU Grenoble Alpes, University Clinic of hematology, Grenoble, France 14 Hôpital Saint Louis, Assistance Publique - Hôpitaux de Paris, Paris, France 15 Biostatistic, Saint-Louis Hospital, APHP, Paris, France 16 Service d’Hématologie Séniors,, St Louis hospital, University Paris 7, Paris, France 17 Groupe Francais des myélodysplasies (GFM), Paris, France 18 Saint-Louis Hospital, University Paris 7, Paris, France 788 Second TKI Discontinuation in CML Patients That Failed First Discontinuation and Subsequently Regained Deep Molecular Response after TKI Re-Challenge Chronic Myeloid Leukemia: Therapy Program: Oral and Poster Abstracts Type: Oral Session: 632. Chronic Myeloid Leukemia: Therapy: TKI-Discontinuation 1* 2,3 4* 5* Thomas Pagliardini , Franck E. Nicolini, MD, PhD , Stephane Giraudier, MD, PhD , Philippe Rousselot , 2,6* 2,7* 2,8* Gabriel Etienne, MD, PhD , Françoise Huguet, MD , Agnes Guerci-Bresler, MD, PhD , Bruno R. Varet, MD 9 10* 11* 12,13 PhD , Martine Escoffre, MD , Stephane Morisset, Stat , Francois-Xavier Mahon and Laurence Legros, 2,14* MD, PhD 1 CHU de Nice, Nice, France 2 Fi-LMC group, Pessac, France 3 Centre Hospitalier Lyon Sud, Pierre-Bénite, France 4 Hôpital Henri-Mondor, Créteil, France 5 Centre Hospitalier, Versaille, FRA 6 Hematology Department, Institut Bergonie, Bordeaux, France 7 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 8 Hematology Department, CHU Brabois, Nancy, France 9 Hematology Department, Hopital Necker-Enfants Malades / Paris Sorbonne Cité, Paris, France 10 CHU Rennes, Rennes, France 11 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 12 Cancer Center of Bordeaux, Institut Bergonié, INSERM U1218, University of Bordeaux, Bordeaux, France 13 FILMC group, Bordeaux, France 14 Institut de Biologie Valrose, iBV, Nice, France 3705 A Retrospective Analysis of Pneumocystis Jirovecii Pneumonia Infection in Patients Receiving Idelalisib in Clinical Trials Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections Program: Oral and Poster Abstracts Session: 203. Lymphocytes, Lymphocyte Activation, and Immunodeficiency, including HIV and Other Infections: Poster III 1 2 3 4 5 6 Laurie H Sehn, MD , Michael Hallek , Wojciech Jurczak , Jennifer R. Brown , Paul M. Barr , John Catalano , 7 8 9 10* 11 Steven E. Coutre, MD , Richard R. Furman , Nicole Lamanna , Ysebaert Loïc , Andrew D. Zelenetz , Jeffrey P. 12 13* 14 14* 15 Sharman , Sven DeVos , Adeboye Henry Adewoye , Yeonhee Kim , Ian W. Flinn, MD, PhD and Gilles A. 16 Salles 1 Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada 2 Dep. 1 of Internal Medicine, University of Cologne, Cologne, Germany 3 Department of Haematology, Jagiellonian University, Kraków, Poland 4 CLL Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 5 Wilmot Cancer Institute, University of Rochester, Rochester, NY 6 Frankston Hospital and Monash University, Frankston, Australia 7 Stanford University School of Medicine, Stanford, CA 8 Weill Cornell Medical College, New York, NY 9 Leukemia Service, Division of Hematology and Oncology, Herbert Irving Comprehensive Cancer Center, College of Physicians and Surgeons, Columbia University Medical Center, New York, NY 10 Service d'Hématologie, Cancer Research Center of Toulouse, Toulouse, France 11 Memorial Sloan Kettering Cancer Center, New York, NY 12 Willamette Valley Cancer Institute and Research Center, US Oncology Research, Springfield, OR 13 David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 14 Gilead Sciences, Inc., Foster City, CA 15 Sarah Cannon Research Institute, Nashville, TN 16 Hospices Civils de Lyon, Centre Hospitalier Lyon Sud, Service d’Hematologie, Universite Claude Bernard Lyon 1, Lyon, France 347 Results of a Phase II Study of Guadecitabine (SGI-110) in Higher Risk MDS, CMML or Low Blast Count AML Patients Refractory to or Relapsing after Azacitidine (AZA) Treatment Myelodysplastic Syndromes—Clinical Studies Program: Oral and Poster Abstracts Type: Oral Session: 637. Myelodysplastic Syndromes—Clinical Studies: Higher Risk MDS Clinical Studies 1,2* 3* 4* 5* Marie Sebert, MD , Cecile Bally , Pierre Peterlin, MD , Odile Beyne-Rauzy, MD, PhD , Laurence Legros, MD, 6* 7* 8* 9 PhD , marie Pierre Gourin, MD, PhD , Laurence Sanhes, MD , Eric Wattel, MD PhD , Emmanuel Gyan, MD, 10 11* 12* 13* 14* PhD , Sophie Park, MD, PhD , Aspasia Stamatoullas, MD , Anne Banos , Kamel Laribi, MD , Simone 15* 16* 17* 18* 1* 1* Jueliger, PhD , Luke Bevan , Cendrine Chaffaut , Rosa Sapena , Benedicte Samey , Fatiha Chermat , 19* 20 21 Sylvie Chevret , Lionel Ades, MD, PhD and Pierre Fenaux, MD, PhD 1 GFM, Hôpital Saint Louis, Paris, France 2 Service d’Hématologie Séniors, Hôpital St Louis, Université Paris 7, Paris, France 3 Hopital Saint Louis, Paris, France 4 HOPITAL HOTEL DIEU ET HME, NANTES CEDEX 1, FRA 5 Service de medecine Interne, CHU Purpan, Toulouse, France 6 Hematology department, Hopital Archet 1, CHU Nice, Nice, France 7 CHU, Limoges, France 8 Department of Hematology, CH Perpignan, Perpignan, France 9 Lyon I University, Lyon, France 10 Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France 11 CHU Grenoble Alpes, University Clinic of hematology, Grenoble, France 12 Clinical Hematology, Centre Henri Becquerel, Rouen, France 13 Centre Hospitalier de la Cote basque, Bayonne, France 14 Centre Hospitalier, Le Mans, France 15 ASTEX pharmaceuticals, Cambridge, GBR 16 Astex Pharmaceutical, Cambridge, United Kingdom 17 Departement de biostatistiques, hôpital Saitn-Louis, Paris, France 18 Clinical Hematology, CHU Cochin, Paris, France 19 Statistics St-Louis Hospital, Paris 7, Paris, France 20 Service d’Hématologie Séniors,, St Louis hospital, University Paris 7, Paris, France Saint-Louis Hospital, University Paris 7, Paris, France 21 4060 Safety, Phamacokinetics (PK), Pharmacodynamics (PD) and Preliminary Activity in Acute Leukemia of Ory-1001, a First-in-Class Inhibitor of Lysine-Specific Histone Demethylase 1A (LSD1/KDM1A): Initial Results from a First-in-Human Phase 1 Study Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 616. Acute Myeloid Leukemia: Novel Therapy, excluding Transplantation: Poster III 1 2* 3* 4* Tim Somervaille, MD PhD , Olga Salamero, MD , Pau Montesinos, MD, PhD , Christophe Willekens, MD , Jose 5* 6* 7 8* Antonio Perez Simon, MD , Arnaud Pigneux, MD , Christian Recher, MD, PhD , Rakesh Popat , Cesar 9* 9* 10* 11 Molinero, MD, PhD , Christina Mascaro, PhD , Tamara Maes, PhD and Francesc Bosch, MD, PhD 1 The Christie NHS Foundation Trust, Manchester, United Kingdom 2 Hospital Universitari Vall d'Hebron, Barcelona, Spain 3 Hematology, Hospital Universitari i Politècnic La Fe de Valencia, Valencia, Spain 4 Clinical Hematology, Gustave Roussy Cancer Center, Villejuif, France 5 Hospital Universitario Virgen del Rocío, Seville, Spain 6 Hôpitaux du Haut Lévéque CHU Bordeaux, Pessac, France 7 Service d'Hématologie, Institut Universitaire du Cancer de Toulouse Oncopole - CHU de Toulouse, Toulouse, France 8 Haematology, University College London Hospitals NHS Foundation Trust, London, United Kingdom 9 Oryzon Genomics, Barcelona, Spain 10 Oryzon Genomics, Cornella De Llobregat, ESP 11 Department of Hematology, University Hospital Vall d'Hebron, Barcelona, Spain 2541 A Multicenter Study Evaluating the Safety of Romiplostim at Maximal Dosage for Emergency Bleeding Situations in Immune Thrombocytopenia Disorders of Platelet Number or Function Program: Oral and Poster Abstracts Session: 311. Disorders of Platelet Number or Function: Poster II 1* 2* 3* 4* Mathilde Roumier, MD , Louis Terriou, MD , Mohamed Hamidou, MD, PhD , Antoine Dossier, MD , Anne 5* 6* 7* 8* Sophie Morin, MD , Virginie Zarrouk, MD , Mickael Ebbo, MD , Guillaume Moulis, MD, PhD , Lionel Galicier, 9* 10* 11* 12* 13* MD , Sylvain Audia, MD, PhD , Laetitia Languille , Marie Goussef, MD , Solène Poutrel, MD , Marc 14* 14* 11* Michel, MD, , Bertrand Godeau, MD, PhD and Matthieu Mahévas, MD, PhD 1 Internal Medicine, French referral center for adult's immune cytopenia, Henri Mondor Hospital, AP-HP, UPEC University, Creteil, France 2 Department of Internal Medecine, clinical immunology, Hôpital HURIEZ CHRU Lille, Lille, France 3 Department of Internal Medicine, Hôtel Dieu University Hospital, Nantes, France 4 Department of internal Medicine, Hôpital Bichat, Paris, France 5 Department of internal medicine, Hôpital Jean Verdier, Bondy, France 6 Deprtment of internal medicine, Hôpital Beaujon, Clichy, France 7 Department of internal medicine, Assistance publique Hôpitaux de Marseille, marseille, France 8 Internal Medicine Department, Toulouse University Hospital; UMR 1027 Inserm-, Toulouse, France 9 St-Louis University Hospital, Paris, France 10 Department of internal medicine, Dijon university hospital, Dijon, FRA 11 Centre national de référence des cytopénies auto-immunes de l'adulte, Hôpital Henri-Mondor, APHP, Créteil, France 12 Deprtment of Internal Medicine, Centre hospitalier Bretagne Atlantique, Vannes, France 13 Department of Internal Medicine, Lyon university hospital, Lyon, France 14 Internal Medicine, French referral center for adult's immune cytopenia, Henri Mondor Hospital, AP-HP, UPEC University, Créteil, France 356 A Detailed Alternate Splicing Landscape in Multiple Myeloma with Significant Potential Biological and Clinical Implications Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Insights from Molecular Alterations and Alternate Splicing 1,2* 3* 4* 5,6* Anil Aktas Samur, PhD , Mehmet Kemal Samur, PhD , Stephane Minvielle, PhD , Florence Magrangeas , 7 8* 9 10 Mariateresa Fulciniti, PhD , Raphael Szalat , Paul G. Richardson, MD , Kenneth C. Anderson, MD , Michel 11 12* 3* 13* 7,14 Attal , Philippe Moreau , Giovanni Parmigiani, PhD , Hervé Avet-Loiseau and Nikhil C Munshi, MD 1 Department of Biostatistics and Computational Biology, Dana Farber Cancer Institute, Boston, MA 2 Department of Biostatistics, Harvard Chan School of Public Health, Boston, MA 3 Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 4 Unité Mixte de Genomique du Cancer, Centre Hospitalier Universitaire de Nantes, Nantes, France 5 Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France 6 Centre Hospitalier Universitaire de Nantes, Unité Mixte de Genomique du Cancer, Nantes, France 7 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 8 Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 9 Division of Hematologic Malignancy, Department of Medical Oncology, Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 10 Jerome Lipper Multiple Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 11 Institut Universitaire du Cancer-Oncopole, Toulouse, France 12 Department of Hematology, Nantes University Hospital, Nantes, France 13 Centre de Recherche en Cancérologie de Toulouse Institut National de la Santé et de la Recherche Médicale, Toulouse, France 14 VA Boston Healthcare System, Boston, MA 236 The Complex Landscape of Rearrangements in Smoldering and Symptomatic Multiple Myeloma Revealed By Whole-Genome Sequencing Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Progression 1* 2,3* 2,4* 5* 4* Raphael Szalat , Niccolo Bolli, MD , Francesco Maura , Stephane Minvielle, PhD , Dominik Gloznik , 6* 7* 4* 8* 4* Florence Magrangeas , Philippe Moreau , Anthony Fullam , Mehmet K. Samur, PhD , Patrick Tarpey , 9 4* 4* 4* 4* Nicholas Anthony DaSilva, BS , Helen Davies , Inigo Martincorena , Kevin J. Dawson , Jose Tubio, PhD , Jorge 4* 10 10 4,11* 12* Zamora , Yu-Tzu Tai, PhD , Kenneth C. Anderson , David Wedge , Hervé Avet-Loiseau , Peter J Campbell, 13* 10 MD, PhD and Nikhil C Munshi, MD 1 Medical Oncology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 2 Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 3 Wellcome Trust Sanger Institute, Cambridge, United Kingdom 4 Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton, United Kingdom 5 Unité Mixte de Genomique du Cancer, Centre Hospitalier Universitaire de Nantes, Nantes, France 6 Centre de Recherche en Cancérologie Nantes-Angers UMR Inserm 892—CNRS 6299 and Institut de Recherche Thérapeutique de l’Université de Nantes (IRT-UN), Nantes, France 7 Department of Hematology, Nantes University Hospital, Nantes, France 8 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 9 University of Rhode Island, Kingston, RI 10 Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 11 University of Oxford, Big Data Institute, Oxford, United Kingdom 12 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 13 Cancer genome Project, Wellcome Trust Sanger Institute, Cambridge, United Kingdom 4643 Refined Graft-Versus-Host Disease-Free, Relapse-Free Survival after Allogeneic Hematopoietic Stem Cell Transplantation in Patients with Intermediate and Unfavorable Prognosis Acute Myeloid Leukemia Ttransplanted in First Complete Remission from HLA-Identical Related or Unrelated Donors: A Retrospective Study on Behalf of the ALWP of the EBMT Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Session: 731. Clinical Autologous Transplantation: Results: Poster III 1,2* 2* 2,3,4* 5 Giorgia Battipaglia , Annalisa Ruggeri , Myriam Labopin, MD , Liisa Volin, MD, PhD , Didier Blaise, MD, 6 7* 8 9 PhD , Gerard Socié, MD, PhD , Noel Milpied, MD , Jan J. Cornelissen, MD, PhD , Ardeshir Ghavamzadeh, 10 11* 12* 13 14* Professor , Anne Huynh, MD , Wu Depei , Ibrahim Yakoub-Agha, MD, PhD , Johan Maertens, MD, PhD , 15* 2,16,17 3,18 Patrice Chevallier, MD, PhD , Mohamad Mohty, MD, PhD and Arnon Nagler, MD, MSc 1 Hematology Department, Federico II University, Naples, Italy 2 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France 3 Acute Leukemia Working Party of the EBMT, Paris, France 4 Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France, Paris, France 5 Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland 6 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 7 Hopital St. Louis, Dept.of Hematology – BMT, Paris, France 8 Service d’Hematologie Clinique et Therapie Cellulaire, CHU Haut-Lévêque, Bordeaux, France 9 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands 10 Hematology-Oncology and Stem Cell Transplantation Research Center, Tehran University of Medical Sciences, Tehran, Iran 11 Institut Universitaire du Cancer Toulouse, Oncopole, Toulouse, France 12 First Affiliated Hospital of Soochow University, Department of Hematology, Suzhou, China 13 Hematology, Hôpital HURIEZ UAM allogreffe de CSH, CHRU, Lille, France 14 Department of Hematology, University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium 15 Department of Hematology, Nantes University Hospital, Nantes, France 16 Hematology and Cellular Therapy, Hospital Saint-Antoine, Paris University UPMC, INSERM U938, Paris, France 17 EBMT, Acute Leukemia Working Party, Paris, France 18 Division of Hematology, Sheba Medical Center, Ramat Gan, Israel 3245 Responses Assigned Using Heavy+Light Chain Assessments Have Better Clinical Correlation with Outcome Than Those Using Current IMWG Criteria for Multiple Myeloma Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster II 1 2* 2* Mauricette Michallet, MD, PhD , Colette Chapuis-Cellier, Dr , Christine Lombard, Dr , Mohamad Sobh, 3* 4* 5* 6 7* PharmD , Thomas Dejoie, PharmD , Helene Caillon, PharmD , Michel Attal , Philippe Moreau and Hervé 8* Avet-Loiseau 1 Department of Hematology, Centre Hospitalier Lyon-Sud, Lyon, France 2 Centre Hospitalier Lyon-Sud, Lyon, France 3 Hematology department 1G, Centre Hospitalier Lyon Sud, Pierre Benite, France 4 Biochemistry Laboratory, Centre Hospitalier Universitaire-Nantes, Nantes, France 5 Biochemistry Laboratory, Nantes University Hospital, Nantes, France, Nantes, France 6 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 7 Department of Hematology, Nantes University Hospital, Nantes, France 8 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 2892 Whole Exome Analysis of Relapsing Patients with Acute Promyelocytic Leukemia Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis Program: Oral and Poster Abstracts Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster II 1* 1* 2* 3 4* Cecile Bally , Jacqueline Lehmann-Che , Bruno Cassinat, PharmD, PhD , Lionel Ades, MD, PhD , Eric Letouze , 5,6* 7* 8 9* Pierre Hirsch , Marie-Joelle Mozziconacci , Sophie Raynaud, MD , Eric Delabesse, PharmD, PhD , Madalina 10* 11* 12* 13* Uzunov, MD , Mathilde Hunault, MD, PhD , Eric Lippert, PhD , Hélène Lapillonne, MD, PhD , Christophe 14 15* 16* 17* Ferrand, PhD , Carine Gervais, MD , Nathalie Gachard, PhD, , Agnès Guerci, MD, PhD , Pierre Fenaux, MD, 18 19 PhD and Hugues de The, MD, PhD 1 Hopital Saint Louis, Paris, France 2 Service de Biologie Cellulaire, AP-HP, Hôpital Saint-Louis, Paris, France 3 Service d’Hématologie Séniors,, St Louis hospital, University Paris 7, Paris, France 4 Integragen/GECO, Paris, France 5 INSERM U938, Paris, France 6 Service d'Hematologie et de Therapie cellulaire, Hopital St Antoine, Paris, France 7 Department of Cancer Biology, Institut Paoli Calmettes, Marseille, France 8 Laboratoire d'Oncohematolgie, Hopital Pasteur, Nice, France 9 Laboratory of Hematology, UMR1037-INSERM, ERL5294 CNRS, Toulouse, France 10 Hematology Department, Pitie-Salpetriere Hospital, Paris, France 11 Hematology, Medical University Hospital, Angers, France 12 Laboratory of hematology, University Hospital Center of Bordeaux, Pessac, France 13 Hematology Laboratory, Trousseau Hospital, HUEP, APHP, Paris, France 14 EFS BFC, Inserm UMR1098, University hospital Besancon, University Franche Comte, Besancon, France 15 LRCHA, Strasbourg - Mulhouse, France 16 limoges, limoges, France 17 Hématologie Clinique, CHU Nancy-Brabois, Vandoeuvre, France 18 Saint-Louis Hospital, University Paris 7, Paris, France 19 Univ. of Paris, Hospital St. Louis, Paris, France 4428 Free Light Chain Escape in Multiple Myeloma : an Exceptional Phenomenon Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster III 1* 2 3* 4* 5* Helene Caillon, PharmD , Michel Attal , Hervé Avet-Loiseau , Cyrille Touzeau, MD , Philippe Moreau and 6* Thomas Dejoie, PharmD 1 Biochemistry Laboratory, Nantes University Hospital, Nantes, France, Nantes, France 2 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 3 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 4 Department of hematology, Nantes university Hospital and UMR892 INSERM, Nantes, France 5 Department of Hematology, Nantes University Hospital, Nantes, France 6 Biochemistry Laboratory, Centre Hospitalier Universitaire-Nantes, Nantes, France 512 Comparable Results of Autologous and Allogeneic Hematopoietic Stem Cell Transplantation for Adult Patients with Philadelphia-Positive Acute Lymphoblastic Leukemia in First Complete Molecular Remission: An Analysis By the Acute Leukemia Working Party of the EBMT Clinical Autologous Transplantation: Results Program: Oral and Poster Abstracts Type: Oral Session: 731. Clinical Autologous Transplantation: Results: Clinical Autologous Transplantation 1* 2,3* 4 5* 6* Sebastian Giebel , Myriam Labopin, MD , Michael Potter , Xavier Poiré, MD , Henrik Sengeloev, MD , 7* 8* 9* 10 11* Gerard Socié, MD, PhD , Anne Huynh, MD , Boris V Afanasyev, Professor , Urs Schanz, MD , Olle Ringden , 12 13 14 15 Peter Kalhs, MD , Dietrich W. Beelen, Prof. Dr. med. , Antonio M. Campos, MD , Tamás Masszi, MD, PhD , 2,16 2,17 Mohamad Mohty, MD, PhD and Arnon Nagler*, MD 1 Department of Bone Marrow Transplantation and Oncohematology, Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice, Poland 2 Acute Leukemia Working Party of the EBMT, Paris, France 3 Service d’Hématologie et Thérapie Cellulaire, Hôpital Saint-Antoine, Paris, France The Royal Marsden Center, London, United Kingdom 5 Section of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium 6 Department of Hematology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark 7 Hopital St. Louis, Dept.of Hematology – BMT, Paris, France 8 Institut Universitaire du Cancer, Oncopole IUCT, Toulouse, France 9 R.M. Gorbacheva Memorial Institute of Children Oncology, Hematology and Transplantation, Academician I.P.Pavlov First St.Petersburg State Medical University, Saint-Petersburg, Russia 10 Division of Hematology, University Hospital Zurich, Zurich, Switzerland 11 Karolinska Institutet, Stockholm, Sweden 12 Medical University of Vienna, Vienna, AUT 13 Department of Bone Marrow Transplantation, West German Cancer Center, University Hospital Essen, Essen, Germany 14 Serviço de Transplantação de Medula Óssea, Instituto Português de Oncologia, Porto, Portugal 15 St. István & St. Laszlo Hospital Semmelweis University St. Laszlo Campus, Budapest, Hungary 16 Department of Haematology, EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 17 Chaim Sheba Medical Center, Tel-Hashomer, Israel 4 376 Serum Free Light Chain Responses Have Greater Concordance with Clinical Outcomes Than Those Assessed By Urine Electrophoresis in Light Chain Multiple Myeloma Patients Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Clinical Insights from Multiple Myeloma Biology and Biomarkers 1* 2 3* 4* Thomas Dejoie, PharmD , Michel Attal , Philippe Moreau and Hervé Avet-Loiseau 1 Biochemistry Laboratory, Centre Hospitalier Universitaire-Nantes, Nantes, France 2 Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France 3 Department of Hematology, Centre Hospitalier Universitaire-Nantes, Nantes, France 4 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France Introduction 3242 The Impact of Atrial Fibrillation on Subsequent Survival of Patients Receiving Ibrutinib As Treatment of Chronic Lymphocytic Leukemia (CLL): An International Study CLL: Therapy, excluding Transplantation Program: Oral and Poster Abstracts Session: 642. CLL: Therapy, excluding Transplantation: Poster II 1* 2* 3 4* Philip A Thompson, MBBS , Vincent Levy, MD, PhD , Constantine S. Tam, MBBS , Chadi al Nawakil, MD , 5* 6* 7* 8* Francois Xavier Goudot, MD , Anne Quinquenel, MD , Loic Ysebaert, MD, PhD , Anne-Sophie Michallet, MD , 9* 10 11* 1 Marie Sarah Dilhuydy, MD , Eric W Van Den Neste, MD, PhD , Jehan Dupuis, MD , Michael Keating, MBBS , 12* 13 Christophe Meune, MD, PhD and Florence Cymbalista, MD, PhD 1 Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 2 Hôpital Avicenne, Bobigny, France 3 Peter MacCallum Cancer Centre & St. Vincent's Hospital, Melbourne, Australia 4 CRC, Hôpital Avicenne, Bobigny, France 5 Service de Cardiologie, Hôpital Avicenna, Bobigny, France 6 Hopital Robert Debre, Reims, France 7 Haematology dept, IUCT oncopole, Toulouse, France 8 Centre Léon Bérard, Lyon, France 9 Hôpital Haut-Lévêque, Pessac, France 10 Department of Hematology, Cliniques Universitaires Saint-Luc, Brussels, Belgium 11 Lymphoid Malignancies Unit, APHP, Groupe Hospitalier Mondor, CRETEIL, France 12 Service de Cardiologie, Hôpital Avicenna, bobigny, France 13 Service d'hématologie biologique, Hôpital Avicenne, Bobigny, France 2899 Impact of FAB Classification on Predicting Outcome in Acute Myeloid Leukemia, Not Otherwise Specified, Patients Undergoing Allogeneic Stem Cell Transplantation in CR1: An Analysis of 1690 Patients from the Acute Leukemia Working Party of EBMT Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis Program: Oral and Poster Abstracts Session: 617. Acute Myeloid Leukemia: Biology, Cytogenetics, and Molecular Markers in Diagnosis and Prognosis: Poster II 1 2* 3* 4 5* Jonathan Canaani, MD , Eric Beohou , Myriam Labopin , Gerard Socie, MD, PhD , Anne Huynh, MD , Liisa 6 7 8 9* Volin, MD, PhD , Jan J. Cornelissen, MD, PhD , Noel Milpied, MD PhD , Tobias Gedde-Dahl , Eric Deconinck, 10 11* 12 13 14 MD, PhD , Jeremy Delage, MD , Didier Blaise, MD, PhD , Mohamad Mohty, MD, PhD and Arnon Nagler 1 Hematology Division, Chaim Sheba Medical Center, Tel-Hashomer, Israel Hopital Saint-Antoine, EBMT, Acute Leukemia Working Party and Registry, Paris, France 3 EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 4 St-Louis Hospital, Paris, France 5 Institut Universitaire du cancer, Oncopole IUCT, Toulouse, France 6 Helsinki University Hospital, Comprehensive Cancer Center, Helsinki, Finland 7 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands 8 Service d'Hématologie et de Thérapie Cellulaire, CHU Haut-Leveque and University of Bordeaux, Bordeaux, France 9 Dept of Internal Medicine, Oslo University Hospital, Oslo, Norway 10 Department of Hematology, CHU Besancon, Besancon, France 11 Service d’Hematologie Clinique et Therapie Cellulaire, CHU de Bordeaux, Pessac, France 12 Programme de Transplantation et Therapie Cellulaire, Institut Paoli Calmettes, Marseille, France 13 Hôpital Saint-Antoine, EBMT, Acute Leukemia Working Party and Registry, Paris, France 14 Chaim Sheba Medical center and EBMT Acute Leukemia Working Party, Tel-Hashomer and Paris, Israel 2 2008 Prospective Evaluation of the Effect of Deferasirox on Hematologic Response in Transfusion-Dependent Patients with Low-Risk MDS and Iron Overload: The Rythmex Study Myelodysplastic Syndromes—Clinical Studies Program: Oral and Poster Abstracts Session: 637. Myelodysplastic Syndromes—Clinical Studies: Poster I 1 2* 3 4* 5* Christian Rose, MD, , Olivier Fitoussi, MD , Emmanuel Gyan, MD, PhD , Maya Hacini, MD , Shanti Amé, MD , 6* 7* 8* Bernadette Corront, MD , Odile Beyne-Rauzy, MD, PhD , Didier Innocent Adiko, MD , Elena-Anca Loppinet, 9* 10* 11 12* MD , Nadia Ali-Ammar, MD , Eric Wattel, MD PhD , Francois Dreyfus, MD and Stéphane Cheze, MD, 13* PhD 1 Hématologie clinique, Hôpital Saint Vincent de Paul, Université Catholique de Lille, Lille, France 2 Polyclinique Bordeaux Nord-Aquitaine, Bordeaux, France 3 Service d'Hématologie et thérapie cellulaire, Centre Hospitalier Universitaire, Tours, France 4 service d'hematologie, Chambery, France 5 Hematology department, Hôpital Civil , CHU Strasbourg, Strasbourg, France 6 Centre Hospitalier Annecy-Gennevois,, Annecy, France 7 Service de medecine Interne, CHU Purpan, Toulouse, France 8 Hôpital Robert Boulin, Libourne, Libourne, FRA 9 service d'hématologie, CH Metz, Metz, France 10 service d'hématologie, CH Troyes, Troyes, France 11 Lyon I University, Lyon, France 12 CHU Cochin, Hematology, Paris, France 13 Institut d’Hématologie de Basse-Normandie, CHU Caen Hôpital Côte de Nacre, Caen, France 4462 Global Genomic Analysis of Newly Diagnosed t(4 ;14) Multiple Myeloma Reveals a Specific Mutational Spectrum and Identifies PKD2 As a Potential Therapeutic Target Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy Program: Oral and Poster Abstracts Session: 652. Myeloma: Pathophysiology and Pre-Clinical Studies, excluding Therapy: Poster III 1* 2,3* 4* 1* 5,6* Xiu Ly Song , Raphaël Szalat, MD , Alexis Talbot, MD , HaiVu Nguyen, pHD , Mehmet K. Samur, PhD , 7,8* 9 10* 11* David Mosen-Ansorena, PhD , Nikhil C. Munshi, MD , Stephane Minvielle, PhD , Hervé Avet-Loiseau , 12* 1,13 1,14* Wendy Cuccuini, MD, PhD , Jean-Paul Fermand, MD , Bertrand Arnulf, MD, phD and Jean-Christophe 15* Bories 1 INSERM, UMR 1126, Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France 2 Medical Oncology, Harvard Medical School, Boston, MA 3 Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 4 INSERM, UMR 1126, Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité,, Paris, France 5 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 6 The LeBow Institute for Myeloma Therapeutics and Jerome Lipper Myeloma Center, Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 7 Harvard School of Public Health, Boston, MA 8 Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 9 Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 10 Unité Mixte de Genomique du Cancer, Centre Hospitalier Universitaire de Nantes, Nantes, France 11 Institut Universitaire du Cancer and University Hospital, Unité de Génomique du Myélome, Toulouse, France 12 Haematology Laboratory, Saint-Louis Hospital, APHP, Paris, France 13 Immuno-Hematology Unit, Saint-Louis Hospital, Paris, France 14 INSERM, UMR 1126, Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, France;, Paris, France 15 INSERM, UMR 1126, Institut Universitaire d'Hématologie, Université Paris Diderot, Sorbonne Paris Cité, Paris, FRA 4563 Anti-Thymocyte Globulin for Graft-Versus-Host Disease Prophylaxis in Patients with Acute Myeloid Leukemia Undergoing Reduced Intensity Conditioning Allogeneic Stem Cell Transplantation in First Complete Remission: A Survey on Behalf of the EBMT Acute Leukemia Working Party Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution Program: Oral and Poster Abstracts Session: 722. Clinical Allogeneic Transplantation: Acute and Chronic GVHD, Immune Reconstitution Poster III 1,2 3* 4* 5 6 Yishai Ofran, MD , Eric Beohou , Myriam Labopin , Didier Blaise, MD, PhD , Jan J. Cornelissen, MD, PhD , 7 8* 9* 10* Marco R De Groot, MD, PhD , Gerard Socié, MD, PhD , Anne Huynh, MD , Johan Maertens, MD, PhD , 11 12 3,13 Frederic Baron, MD, PhD , Mohamad Mohty, MD, PhD and Arnon Nagler 1 Department of Hematology and BMT, Rambam Health Care Campus, Haifa, Israel 2 Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel 3 Hopital Saint-Antoine, EBMT, Acute Leukemia Working Party and Registry, Paris, France 4 EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 5 Programme de Transplantation &Therapie Cellulaire, Centre de Recherche en Cancérologie de Marseille, Institut Paoli Calmettes, Marseille, France 6 Department of Hematology, Erasmus MC Cancer Institute, Rotterdam, Netherlands 7 Department of Hematology, University of Groningen, University Medical Center Groningen, Groningen, Netherlands 8 Hopital St. Louis, Dept.of Hematology – BMT, Paris, France 9 Institut Universitaire du Cancer, Oncopole IUCT, Toulouse, France 10 Department of Hematology, University Hospital Gasthuisberg, Dept. of Hematology, Leuven, Belgium 11 Hematology & GIGA Research, University of Liege, Liege, Belgium 12 Department of Haematology, EBMT Paris study office / CEREST-TC / Saint Antoine Hospital, Paris, France 13 Division of Hematology and Bone Marrow Transplantation, Chaim Sheba Medical Center, Tel-Hashomer, and Sackler School of Medicine, Tel-Aviv University, Tel Aviv, Israel 2070 Evaluation of the Concordance of Two Free Light Chains Assays to Identify High Risk Smoldering Myeloma Patients. Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Poster I 1* 1* 2* 3* 2* 3 Caroline Moreau , Emmanuel Rouger , Basile Henriot , Martine Escoffre , Martine Sebillot , Thierry Lamy , 4* 5* 2* Stéphane Minvielle , Hervé Avet-Loiseau and Olivier Decaux, MD, PhD 1 Biochemistry, University Hospital CHU Rennes, Rennes, France 2 Internal Medicine, University Hospital CHU Rennes, Rennes, France 3 Hematology, University Hospital CHU Rennes, Rennes, France 4 UMR 892 Inserm - 6299 CNRS, Nantes, France 5 Institut Universitaire du Cancer and University Hospital, Unité de Génomique du Myélome, Toulouse, France 195 RNA-Seq De Novo Assembly of Clonal Immunoglobulin Rearrangements Identifies Interesting Biology and Uncovers Prognostic Features in Multiple Myeloma Myeloma: Biology and Pathophysiology, excluding Therapy Program: Oral and Poster Abstracts Type: Oral Session: 651. Myeloma: Biology and Pathophysiology, excluding Therapy: Prognostic Factors 1,2* 3* 4,5* David Mosen-Ansorena, PhD , Rachael Bashford-Rogers, PhD , Niccolo Bolli, MD , Stephane Minvielle, 6* 6* 7 8* 2* PhD , Florence Magrangeas , Kenneth C Anderson, MD , Hervé Avet-Loiseau , Giovanni Parmigiani, PhD and 9,10 Nikhil C Munshi, MD 1 Harvard School of Public Health, Boston, MA 2 Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA 3 Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom 4 Department of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy 5 Wellcome Trust Sanger Institute, Cambridge, United Kingdom 6 Unité Mixte de Genomique du Cancer, Centre Hospitalier Universitaire de Nantes, Nantes, France 7 Dana-Farber Cancer Institute, Medical Oncology, Harvard Medical School, Boston, MA 8 IUC-Oncopole, Unite de Genomique du Myelome, Toulouse, France 9 VA Boston Healthcare System, Boston, MA 10 The Jerome Lipper Multiple Myeloma Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA