bibiliography
Transcription
bibiliography
BIBILIOGRAPHY Abdullah, N., Saat, N.Z.M., Hasan, H.A., Budin, S.B. and Kamaralzaman, S., (2004), “Protective Effect of the Ethanol Extract of Zingiber officinale Roscoe on Paracetamol Induced Hepatotoxicity in Rats”, Jurnal Sains Kesihatan Malaysia, 2, pp. 85-95. Abebe, D., and Ayehu, A., (1993), Medicinal Plants and Enigmatic Health Practices of Northern Ethiopia, Berhan and Selam Printing Enterprise, Addis Ababa, pp 268. Ahmed, M.B., and Khater, M.R., (2001), “Evaluation of the protective potential of Ambrosia maritime extract on acetaminophen-induced liver damage”, Journal of Ethnopharmacology, 75, pp. 169–174. Ahmad, F., Khan, R.A., and Rasheed, S., (1994), “Preliminary screening of methanolic extracts of Celastrus paniculatus and Tecomella undulata for analgesic and antiinflammatory activities”, Journal of Ethnopharmacology, 42(3), pp. 193-198. Ajith, T.A., Hema, U., and Aswathy, (2007), “Zingiber officinale Roscoe prevents acetaminophen-induced acute hepatotoxicity by enhancing hepatic antioxidant status, M.S., Food and Chemical Toxicology, 45, pp. 2267-2272. Akella, V.B., Srinivasarao, S.A., and Gurbachan S.S., (1976), “Chitranone- a new binaphthaquinone from plumbago zeylanica, Phytochemistry”, 15, pp. 237-238. Alexander, B., (1998), “The role of nitric oxide in hepatic metabolism”, Nutrition, 14, pp. 376–390. Ali, B.H., Blunden, G., Tanira, M.O., and Nemmar, A., (2008), “Some phytochemical, pharmacological and toxicological properties of ginger (Zingiber officinale Roscoe): A review of recent research”, Food and Chemical Toxicology, 46, pp. 409-20. Anonymous, (1998), Withdrawal of medicinal products containing ebrotidine: liver Toxicity, WHO Inform Exchange Syst., 72, pp. 1. Artizzu, M., and Dianzani, M.U., (1962), “The changes in the mitochondria and lysosomes in the fatty livers of rats fed with carbon tetrachloride, and their independence of ribonuclease activation”, Biochim Biophys Acta, 63, pp. 453 –464. Avasarala, S., Yang, L., Sun, Y., Leung, A.W., Chanc, W., Cheung, W.T., and Lee, S.S., (2006), “ A temporal study on the histopathological, biochemical and molecular responses of CCl4-induced hepatotoxicity in Cyp2e1-null mice”, Toxicology, 228, pp. 310-322. Azad, A.K., Kunner, S.C., and Azad, (1994), “Isolation and characterization of chemical constituents of Plumbago zeylanica root”, Journal of Bangladesh Academy of Sciences, 5, pp. 71–74. Badger, D. A., Sauer, J. M., Hoglen, N. C., Jolley, C. S., and Sipes, I. G., (1996), “The role of inflammatory cells and cytochrome P450 in the potentiation of CCl4 -induced liver injury by a single dose of retinol”, Toxicol. Appl. Pharmacol., 141, pp. 507–519. Baer-Dubowska, W., Szaefer, H., and Drajka-Kuzniak, V., (1998), “Inhibition of murine hepatic cytochrome P450 activities by natural and synthetic phenolic compounds”, Xenobiotica, 28, pp. 735-43. Basu, S., (2003), “Carbon tetrachloride-induced lipid peroxidation: eicosanoid formation and their regulation by antioxidant nutrients”, Toxicology, 189, pp. 113–127. Batey, R.G., Salmond, S.J., and Bensoussan, A., (2005), Current Gastroenterology Reports, 7, pp. 63-70. Bedossa, P., Houglum, K., Trautwein, C., Holstege, A., and Chojkier, M., (1994), “Stimulation of collagen a, (I) gene expression is associated with lipid peroxidation in hepatocellular injury. A link to tissue fibrosis?”, Hepatology, 19, pp. 1262-1271. Benyon, R.C. and Arthur, M.J., (2001), “Extracellular matrix degradation and the role of hepatic stellate cells”, Semin Liver Dis., 21, pp. 373-84. Beune, P.H., and Lecoeur, J., (1997), “Immunotoxicity of the liver: adverse reactions to drugs”, J. Hepatol., 26, pp. S237–42. Bhandari, U., Shamsher, A.A., Pillai, K.K., and Khan, M.S.Y., (2003), “Antihepatotoxic activity of ginger ethanol extract in rats”, Pharm Biol., 41(1), pp. 68-71. Bhattacharya, S.K, Lal, R., Pandey, V. and Das, P.K., (1971), “Pharmacological investigation on the glycosides of Tecomella undulate (Rugtrora)”, Journal of Research in Indian Medicine, 6, pp. 226-227. Billiar, T. R., (1997), “Resolving the nitric oxide paradox in acute tissue damage”, Gastroenterology, 113, pp. 1405–1407. Bissell, D.M., (2001), “Chronic liver injury, TGF-beta and cancer”, Exp Mol Med, 33, pp. 179–190. Blair, I.A., (2006), “Endogenous glutathione adducts”, Current Drug Metabolism, 7, pp. 853–872. Bonting, S.L., (1970), Sodium-potassium activated adenosine triphosphatase and cation transport. In: Bittar, E.E. (Ed.), Membranes and Ion Transport, 1, WileyInterScience, London, pp. 257-363. Bosisio, E., Benelli, C., Pirola, O., (1992), “Effect of the flavanolignans of Silybum marianum L. on lipid peroxidation in rat liver microsomes and freshly isolated hepatocytes”, Pharmacol Res., 25, pp. 147-54. Botham, P.A., (2004), “Acute systemic toxicity prospects for tiered testing strategies”, Toxicology-in Vitro, 18, pp. 227–230. Bradley, D.W., Maynard, J.E., Emery, G. and Webster, H., (1972), “Transaminase activity in serum of long term. Hemodialysis of patients”, Clin. Chem., 18, pp. 1442. Brattin, W.J., Pencil, S.D., Waller, R.L., Glende, E.A., Recknagel, O., (1984), “Assessment of the role of calcium ion in halocarbon hepatoxocity”, Environ Health Perspect, 57, pp. 321–323. Brenner, D. A., and Chojkier, M., (1987), “Acetaldehyde increases collagen gene transcription in cultured human fibroblasts”, J. Biol. Chem., 262, pp. 1769017695. Byl, B., Roucloux, I., Crusiaux, A., Dupont, E., and Deviere, J., (1993), “Tumor necrosis factor alpha and interleukin 6 plasma levels in infected cirrhotic patients”,Gastroenterology, 104, pp. 1492–1497. Campos, R., Garrido, A., Guerra, R., Valenzuela, A., (1989), “Silybin dihemisuccinate protects against glutathione depletion and lipis peroxidation induced by acetaminophen in rat liver”, Planta Medica, 55, pp. 417-19. Cannell, R.J.P., (1998), Natural Products Isolation (Ed.), Humana Press, ISBN 0-89603, pp. 356-360. Casey, C.A., Nanji, A.A., Cederbaum, A.I., Adachi, M. and Takahashi, T., (2001), “Alcoholic liver disease and apoptosis”, Alcoholism: Clinical and Experimental Research, 25(5), pp. 49S–53S. Cederbaum, A.I., (2001), “Introduction-serial review: alcohol, oxidative stress and cell injury”, Free Radic Biol Med, 31, pp. 1524–6. Chaterjee, T.K., (2000), Medicinal Plants with hepatoprotective properties, Herbal Options, Books & Allied (P) Ltd., Calcutta, pp. 155. Chedid, A., Mendenhall, C. L., Gartside, P., French, S. W., Chen, T., and Rabin, L., (1991), “The VA Cooperative Study Group, Prognostic factors in alcoholic liver disease”, Am J Gastroenterol, 86, pp. 210– 216. Chen, Ch., Kuo, M., Wu, Ch., and Ho, Ch., (1986), “Pungent compounds of ginger (Zingiber officinale (L) Rosc) extracted by liquid carbon dioxide, Journal of Agricultural and Food Chemistry, 34, pp. 477–480. Cheng, G., Bai, Y., Zhao, Y., Tao, J., Liu, Y., Tu, G., Ma, L., Liao, N. and Xu, X., (2000), “Flavonoids from Ziziphus jujuba Mill var. spinosa”, Tetrahedron, 56(45), 3, pp. 8915-8920. Choi, I., Kang, H.S., Yang, Y., and Pyun, K.H., (1994), “IL-6 induces hepatic inflammation and collagen synthesis in vivo.”, Clin Exp Immunol, 95, pp. 530 –535. Chopra, R.N., Nayar, S.L., and Chopra, I.C., (1996), Glossary of Indian medicinal plants, NISCOM Publishers, New Delhi, pp. 55-60. Christie, G.S. and Judah, J.D., (1954), “Mechanism of action of carbon tetrachloride on liver cells”, Proc. Roy. Soc. Lond. Ser. B: Biol. Sci., 142, pp. 241–257. Clemens, M.G., (1999), “Nitric oxide in liver injury”, Hepatology, 30, pp. 1–5. Cottart, C.H., Do, L., Blanc, M. C., Vaubourdolle, M., Descamps, G., Durand, D., Galen, F. X., and Clot, J. P., (1999), “Hepatoprotective effect of endogenous nitric oxide during ischemia-reperfusion in the rat”, Hepatology, 29, pp. 809–813. Dahlin, D.C., Miwa, G.T., Lu, A.Y.H., and Nelson, S.D., (1984), “N-Acetyl-p enzoquinone imine: A cytochrome P-450-mediated oxidation product of acetaminophen”, Proc. Natl. Acad. Sci., 81, pp. 1327-1331. Das. S.K., and Vasudevan. D.M., (2005), “Effect of Ethanol on Liver antioxidant defense systems: A dose dependent study”, Indian J Clin Biochem, 20(1), pp. 80-84. Das, S.K. and Vasudevan, D.M., (2007), “Alcohol-induced oxidative stress”, Life Sciences, 81(3), pp. 177–187. Datta, S.R., Ranger, A.M., Lin, M.Z., Sturgill, J.F., Ma, Y.C., Cowan, C.W., Dikkes, P., Korsmeyer, S.J., and Greenberg, M.E., (2002), “Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis”, Dev. Cell, 3, pp. 631–643. Day, C.P., and James, O.F., (1998), “Hepatic steatosis: innocent bystander or guilty party?”, Hepatology, 27, pp. 1463-14. De, S., Ravishanker, B., and Bhavsar, G.C., (1993), “Plants with hepatoprotective activity: a review”, Indian Drugs, 30(8), pp. 355–363. Deak, G., Muzes, G., lang, I., Niederland, V., Nekam, K., and Gonzales-Cabello, R., (1990), “Immunomodulator effect of silymarin therapy in chronic alcoholic liver disease”, Orv. Hetil, 15, pp. 123-7. Decker, K., (1990), “Biologically active products of stimulated liver macrophages (Kupffer cells)”, Eur. J. Biochem., 192, pp. 245-261. Deleve, L., and Kaplowitz, N., (1991), “Glutathione metabolism and its role in hepatotoxicity”, Pharmacol. Ther., 52, pp. 287– 305. Dev, S., (1997), “Ethnotherapeutic and modern drug development: The potential of Ayurveda”, Current Sci., 73, pp. 909. Diallo, D., Sanogo, R., Yasambou, H., Traoré, A., Coulibaly, K., and Maïga, A., (2004), “Étude des constituants des feuilles de Ziziphus mauritiana Lam. (Rhamnaceae), utilisées traditionnellement dans le traitement du diabète au Mali”, Comptes Rendus Chimie, 7(10-11), pp. 1073-1080. Dianzani, M.U., Meeks, R.G., Harrison, S.D., and Bull, R.J., (1991), Biochemical aspects of fatty liver. In: Hepatotoxicology, eds., CRC Press, Boca Raton, FL, pp. 327399. Dinda, B., and Saha, S., (1989), “A new binapthoquinone from Plumbago zeylanica Linn”, Indian Journal of Chemistry, 28, pp. 984–986. Dinda, B., Hajra, A.K., and Das, S.K., (1998), “Chemical constituents of Plumbago indica roots”, Indian Journal of Chemistry, 37B, pp. 672–675. Dixon, M.F., (1984), Histopathological and enzyme changes in paracetamol-induced liver damage, in: Advances in Inflammation Research, 6, ed. K.D. Rainsford and G.P. Velo (Raven Press, New York), pp.169. Duthie, S.J., Johnson, W., and Dobson, V.L., (1997), “The effect of dietary falavonoids on DNA damage (stand breaks and oxidised pyrimdines) and growth in human cells”, Mutat. Res., 390(1-2), pp. 141-51. Edwards, M.J., Keller, B.J., Kauffman, F.C., and Thurman, R.G., (1993), “The involvement of Kupffer cells in carbon tetrachloride toxicity”, Toxicol. Appl. Pharmacol., 119, pp. 275–279. Eldeen, I.M.S., and Staden, J.V., (2008), “Cyclooxygenase inhibition and antimycobacterial effects of extracts from Sudanese medicinal plants, South African Journal of Botany”, 74(2), pp. 225-229. Ellman, G.L., (1959), “Tissue sulphydryl groups”, Arch Biochem Biophys, 82, pp. 70-77. Erecinska, M., and D.F. Wilson, (1982), “Regulation of cellular energy metabolism”, J. Membr. Biol., 70, pp. 1. Fakurazi, S., Hairuszah, I., and Nanthini, U., (2008), “Moringa oleifera Lam prevents acetaminophen induced liver injury through restoration of glutathione level”, Food and Chemical Toxicology”, 46, pp. 2611–2615. Ferenci, P., Dragosics, B., Dittrich, H., Frank, H., Benda, L., Lochs, H., Meryn, S., Base, W., and Schneider, B., (1989), “Randomized controlled trial of silymarin treatment in patients with cirrhosis of the liver”, J. Hepatol., 9, pp. 105–113. Fiebrich, F., and Koch, H., (1979), “Silymarin, an inhibitor of lipoxygenase”, Experimentia, 35, pp. 1548-60. Fiers, W., (1991), “Tumor necrosis factor: Characterization at the molecular, cellular and in vivo level”, FEBS Lett., 285, pp. 199-212. Fischer, S., Beuers, U., Spengler, U., Zwiebel, F.M., and Koebe, H.G., (1996), “Hepatic levels of bile acids in end-stage chronic cholestatic liver disease”, Clin. Chim. Acta, 2511, pp. 173–186. Flora, K., Hahn, M., Rosen, H., and Brenner,K., (1996), “Milk thistle (Silybum marianum) for the therapy of liver disease”, Am. J.Gastroenterol., 93, pp. 139 -143. Fuchs, E.C., Weyhenmeyer, R., and Weiner, O.H., (1997), “Effects of silibinin and of a synthetic analogue on isolated rat hepatic stellate cells and myofibroblasts”, Arzneimittelforschung, 47, pp. 1383-7. Galun, E., and Axelrod, J.H., (2002), “The role of cytokines in liver failure and regeneration: potential new molecular therapies”, Biochim. Biophys. Acta, 1592, pp. 345–358. Garcia-Trevijano, E.R., Iraburu, M.J., Fontana, L., Dominguez-Rosales, J.A., Auster, A., and Covarrubias-Pinedo A, (1999), “Transforming growth factor 1 induces the expression of (I) procollagen mRNA by a hydrogen peroxide-C/EBP - dependent mechanism in rat hepatic stellate cells”, Hepatology, 29, pp. 960-970. Gardner, C.R., Laskin, J.D., Dambach, D.M., Chiu, H., Durham, S.K., Zhou, P., Bruno, M., Gerecke, D.R., Gordon, M.K., and Laskin, D.L., (2003), “Exaggerated hepatotoxicity of acetaminophen in mice lacking tumor necrosis factor recepto -1. Potential role of inflammatory mediators”, Toxicol Appl Pharmacol, 192, pp. 119–130. Genet, S., Kale, R.K., and Baquer, N.Z., (2000), “Effects of free radicals on cytosolic creatine kinase activities and protection by antioxidant enzymes and sulfhydryl compounds”, Mol Cell Biochem, 210, pp. 23–2. Gonzalez, F.J., (1988), “The molecular biology of cytochrome P450s”, Pharmacol. Rev., 40, pp. 243–288. Gooch, J.L., Gorin, Y., Zhang, B., and Abboud, H.E., (2004), “Involvement of calcineurin in transforming growth factor- -mediated regulation of extracellular matrix accumulation”, J Biol Chem, 279, pp. 15561-15570. Gouville, A.C., Boullay, V., Krysa, G., Pilot, J., Brusq, J.M., Loriolle, F., Gauthier, J.M., Papworth, S.A., Laroze, A., and Gellibert, F., (2005), “Inhibition of TGFsignaling by an ALK5 inhibitor protects rats from dimethylnitrosamine-induced liver fibrosis”, Br J Pharmacol., 145, pp. 166-177. Govindarajan, R., Vijayakumar, M. and Pushpangadan, P., (2005), “Antioxidant approach to Disease management and the Role of ‘Rasayana’ herbs of Ayurveda”, Journal of Ethnopharmacology, 99, 165-178. Goyal, R., Sharma, P.L., and Singh, M., (2010), “Pharmacological Potential of Tecomella undulate in Acute and Chronic Inflammation in Rat”, Int. Jrnl. Pharm. Sci. Res., 1(5), pp. 108-114. Gram, T.E., and Gillette, J.R., (1971), Bio-transformation of drugs. In Fundamentals of Biochemical Pharmacology, ed. Z. M. Bacq, Pergamen Press, New York, pp. 571609. Green, D.R., and Kroemer, G., (2004), “The pathophysiology of mitochondrial cell death”, Science, 305, pp. 626–629. Green, L.C., Wagner, D.A., Glogowski, J., Skipper, P.L., Wishnok, J.S., and Tannenbaum, S.R., (1982), “Analysis of nitrate, nitrite, and nitrate in biological fluids. Anal. Biochem., 126, pp. 131–138. Geerts A., (2001), “History, heterogeneity, developmental biology and functions of quiescent hepatic stellate cells”, Seminars in Liver Disease, 21, pp. 311 - 335. Greim, H., Czygan, P., Schaffner, F., and Popper, H., (1973), “Determination of bile acids in needle biopsies of human liver”, Biochem. Med., 8, pp. 280–286. Gressner, A.M., Weiskirchen, R., Breitkopf, K., and Dooley, S., (2002), “Roles of TGF -beta in hepatic fibrosis”, Front Biosci., 7, pp. d793–d807. Guengerich, F.P., (1994), Analysis and characterization of enzymes, In: Hayes, A.W. (Ed.), Principles and Methods of Toxicology, Raven Press, New York, pp. 1259 -1313. Gujral, V.K., Gupta, S.R., and Verma, K.S., (1979), “Structure of undulatoside B a new chromone glycoside from Tecomella undulate”, Indian Journal of Chemistry, 17B, pp. 40–41. Guler, R., Olleros, M. L., Vesin, D., Parapanov, R., Vesin, C., and Kantengwa, S., (2004), “Inhibition of inducible nitric oxide synthase protects against liver injury induced by mycobacterial infection and endotoxins”, J. Hepatol., 41, pp. 773–781. Guo, S., Tang, Y.P., Duan, J.A., Su, S.L. and Ding, A.W., (2009), “Two new terpenoids from fruits of Ziziphus jujube”, Chinese Chemical Letters, 20(2), pp. s197-200. Gupta, T.K., Toruner, M., Chung, M.K., and Groszmann, R.J., (1998), “Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats”, Hepatology, 28, pp. 926–931. Halliwell, B., (1997), “Antioxidants and human diseases: a general introduction”, Nutrition Reviews, 55, pp. S44–S52. Hammond, C.L., Lee, T.K., and Ballatori, N., (2001), “Novel roles for glutathione in gene expression, cell death, and membrane transport of organic solutes”, J. Hepatol., 34, pp. 946–954. Hampel, B., Malisan, F., Niederegger, H., Testi, R. and Jansen-Durr, P., (2004), “Differential regulation of apoptotic cell death in senescent human cells”, Exp. Gerontol., 39, pp. 1713–1721. Hanauske, H.M., (2003), Fibrosis of the liver: representative molecular elements and their emerging role as anti-fibrotic targets. In: Zakim D, Boyer TD. Hepatology: A Textbook of Liver Disease. 4th ed. Philadelphia: W.B. Saunders, 347-394. Handa, S.S., Sharma, A., and Chakraborthi, K.K., (1986), “Natural products and plants as liver protecting agents”, Fitoterapia, 5, pp. 307–351. Hellerbrand, C., Stefanovic, B., Giordano, F., Burchardt, E. R., and Brenner, D. A., (1999), “The role of TGF1 in initiating hepatic stellate cell activation in-vivo”, J. Hepatol., 30, pp. 77-87. Hinson J.A., Reid A.B., McCullough S.S., and James L.P., (2004), “Acetaminopheninduced hepatotoxicity: role of metabolic activation, reactive oxygen/nitrogen species, and mitochondrial permeability transition”, Drug. Metab. Rev., 36, pp. 805–822. Hinson, J .A, Pohl. Monks, and Gillete J.R., (1981), “Acetaminophen induced hepatotoxicity”, Life Sci., 29, pp. 107-116. Hoek, J.B., and Pastorino, J.G., (2002), “Alcohol, oxidative stress, and liver cell injury”, Alcohol, 27, pp. 63-68. Hoek, J.B., Cahill, A., and Pastorino, J.G., (2002), “Alcohol and mitochondria: a dysfunctional relationship”, Gastroenterology, 122, pp. 2049-2063. Houglum, K., Filip, M., Witztum, J.L., and Chojkier, M., (1990), “Malondialdehyde and 4-hydroxynonenal protein adducts in plasma and liver of rats with iron overload”, J.Clin. Invest., 86, pp. 1991-1998. Hu, K.Q., (2003), Cyclooxygenase 2 (COX2)-prostanoid pathway and liver diseases”, Prostaglandins Leukot. Essent. Fatty Acids, 69, pp. 329–337. Hunter, D.R., and Haworth, R.A., (1979), “The Ca2+-induced membrane transition in mitochondria III. Transitional Ca2+ release, Arch. Biochem. Biophys. 195, pp. 468–477. Hunter, E.B., Johnston, P.E., Tanner, G., Pinson, C.W., and Awad, J.A., (1999), “Bromfenac (Duract)- associated hepatic failure requiring liver transplantation”, Am J Gastroenterol., 94, pp. 2299 - 2301. Husain, K., and Somani, S.M., (1997), “Interaction of exercise training and chronic ethanol ingestion on hepatic and plasma antioxidant system in rat. J. Appl. Toxicol., 17, pp. 189-194. Ikegima, K., Enomoto, N., Iimuro, Y., Ikejima, A., Fang, D., Xu, J., Forman, D.T., Brenner, D.A., and Thurman, R.G., (1998), “Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. American Journal of Physiology”, Gastrointestinal Liver Pathology, 274, pp. G669–G676. Immenschuh, S., Tan, M., and Ramadori, G., (1999), “Nitric oxide mediates the lipopolysaccharide dependent upregulation of the heme oxygenase-1 gene expression in cultured rat Kupffer cells”, J. Hepatol., 30, pp. 61–69. Inngjerdingen, K., Nergård, C.S.N., Diallo, D., Mounkoro, P.P., and Paulsen, B.S., (2004), “An ethnopharmacological survey of plants used for wound healing in Dogonland, Mali, West Africa”, Journal of Ethnopharmacology, 92, pp. 233-244. Ippoushi, K., Azuma, K., Ito, H., Horie, H., and Higashio, H., (2003), “6-Gingerol inhibits nitric oxide synthesis in activated J774.1 mouse macrophages and prevents peroxynitrite- induced oxidation and nitration reactions”, Life Sciences, 73, pp. 3427-3437. Ippoushi, K., Takeuchi, A., Ito, H., Horie, H., and Azuma, K., (2007), “Antioxidative effects of daikon sprout (Raphanus sativus L.) and Ginger (Zingiber officinale Roscoe) in rats”, Food Chemistry, 102, pp. 237–242. Isaacson, Y., and Van-Thiel, D. H., (1988), “Increased membrane fluidity and cholestasis: associated but not linked consequences of estrogen treatment”, J Lab Clin Med., 112, pp. 663–666. Ishibashi, H., Komori, A., Shimoda, S., and Gershwin, M.E., (2007), “Guidelines for Therapy of Autoimmune Liver Disease”, Seminars in liver disease, 27, pp. 2. Jaeschke, H., Gores, G. J., Cederbaum, A. I., Hinson, J. A., Pessayre, D., and Lemasters, J.J., (2002), “Mechanisms of hepatotoxicity”, Toxicol. Sci., 65, pp. 166–176. Jamall, I.S., Finelli, V.N., and Que, H.S.S.. (1981), “A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues”, Anal Biochem, 112, pp. 70-75. James, J.L., Friend, D., MacDonald, J.R., and Smuckler, E.A., (1986), “Alterations in hepatocyte plasma membrane in carbon tetrachloride poisoning. Freeze-fracture analysis of gap junction and electron spin resonance analysis of lipid fluidity”, Lab Invest, 54, pp. 268-274. Javitt, N.B., (1982), Bile acids and hepatobiliary disease. In: Schiff, L., Schiff, E.R. (Eds.), Diseases of the Liver, Lippincott, Philadelphia, pp. 119–150. Jendrassik, L. and Grof, P., (1938), “Determination of total and direct bilirubin in serum or plasma on manual system”, Biochem. Zeitschrift., 297, pp. 81-89. Jeong, D., Lee, G., Jeong, W., Do, S., Yang, H., Yuan, D.W., Park, H.Y., Kim, K.J., and Jeong, K.S., (2005), “Alterations of mast cells and TGF- 1 on the silymarin treatment for CCl4-induced hepatic fibrosis”, World J Gastroenterol, 11, pp. 1141-1148. Joglekar, G.V., Chitale, G.K. and Balwani, J.H., (1963), “Protection by indigenous drugs against hepatotoxic effects of carbon tetrachloride in mice”, Acta Pharmacol. Et Toxicol., 20, pp. 73-79. Jolad, S.D., Lantz, R.C., Chen, G.J., Bates, R.B., and Timmermann, B.N., (2005). “Commercially processed dry ginger (Zingiber officinale): Composition and effects on LPS-stimulated PGE2 production”, Phytochemistry, 66, pp. 1614-1635. Jollow, D.J., Thorgeirsson, S.S., Potter, W.Z., Hashimoto, M., and Mitchell, J.R., (1974), “Acetaminophen-induced hepatic necrosis. VI. Metabolic disposition of toxic and nontoxic doses of acetaminophen”, Pharmacology, 12, pp. 251-271. Joshi, K.C., Prakash, L., and Singh, L.B., (1975), “6-O-veratryl catalposide: A new iridoid glucoside from Tecomella undulate”, Phytochemistry, 14(5-6), pp. 1441 -1442. Junnila, M., Rahko, T., Sukra, A., and Linderberg, L.A., (2000), “Reduction of carbon tetrachloride induced hepatotoxic effects by oral administration of betaine in male Hans-Wistar rats: A morphometric histological study”, Vet. Pathol., 37, pp. 231 -238. Kai, O.L., (1995), “Alcoholic liver disease: Pathobiological aspects”, Journal of Hepatology, 23, pp. 7-15. Kakkar, P., Das, B., and Viswanathan, P.N., (1984), “A modified spectrophotometric assay of superoxide dismutase”, Ind J Biochem Biophys, 21, pp. 131-132. Kamath, P.S., and Kim, W.R., (2007), “The Model for End-Stage Liver Disease (MELD)”, Hepatology, 10, pp. 1002. Kanchana, N., and Sadiq, A.M., (2011), “Hepatoprotective Effect of Plumbago Zeylanica on paracetamol induced liver toxicity in Rats”, International Journal of Pharmacy and Pharmaceutical Sciences, 3(1), pp. 151-154. Kane, J. M., Shears, L.L., Hierholzer, C.H., Ambs, S., Billiar, T.R., and Posner, M.P., (1997), “Chronic hepatitis C virus infection in humans: induction of hepatic nitric oxide synthase and proposed mechanisms for carcinogenesis”, J. Surg. Res. 69, pp. 321–324. Kaplowitz, N., (2004), “Acetaminophen hepatotoxicity: What do we know, what don't we know, and what do we do next?”, Hepatology, 40, pp. 23-26. Kaplowitz, N., (1996), “Drug metabolism and hepatotoxicity. In: Kaplowitz N, ed. Liver and biliary diseases. 2nd ed. Baltimore: Williams & Wilkins”, pp. 103–20. Karandikar, S.M., Joglekar, G.V., Chitale, G.K., and Balwani, J.H., (1963), “Protection by indigenous drugs against hepatotoxic effects of carbon tetrachloride-a lon -term study”, Acta Pharmacol. et Toxicol., 20, pp. 274-280. Kass, G.E.N., and Orrenius, S., (1999), “Calcium signaling and cytotoxicity”, Environ. Health Perspect. 107, pp. s25–35. Kass, G.E.N., Juedes, M.J., and Orrenius, S., (1992), “Cyclosporin A protects hepatocytes against prooxidant-induced cell killing. A study on the role of mitochondrial Ca2+ cycling in cytotoxicity”, Biochem. Pharmacol., 44, pp. 1995–2003. Kessova, I.G., and Cederbaum, A.I., (2007), “Mitochondrial Alterations in Livers of Sod1-/- Mice fed Alcohol”, Free Radical Biology and Medicine, 42, pp. 1470 -1480. Khatri, A., Garg, A. and Agrawal, S.S., (2009), “Evaluation of hepatoprotective activity of aerial parts of Tephrosia purpurea L. and stem bark of Tecomella undulate”, Journal of Ethnopharmacology, 122, pp. 1-5. Kikuzaki, H., and Nakatani, N., (1993), “Antioxidant effect of some ginger constituents” J.Food Sci., 58, pp. 1407–1410. Kim, R., Emi, M., and Tanabe, K., (2006), “Role of mitochondria as the gardens of cell death”, Cancer Chemother. Pharmacol., 57, pp. 545–553. Kim, C.S., Kwon, T.Y., Park, Y., Lee, YB., Park, S., and Chan, M., (2010), “Gallic Acid Diminishes Cellular Proliferation and Pro-Inflammatory Gene Expressions in Fibroblast Like Synoviocytes from Patients with Rheumatoid Arthritis”, Arthritis Rheum, 62, pp. S10-27. Kirtikar, K.R., and Basu, B.D., (2003), Indian Medicinal Plants; Bishen Singh Mahendra Pal singh, Dehradun, 2, 1466, 3, pp. 1841. Kirtikar, K.R., and Basu, B.D., (1984), Indian Medicinal Plants. Bishan Singh Mahendra Pal Singh, Dehra Dun, 724, pp. 1841. Kiso, Y., Tohkin Ino, H., Hatori, M., Sakamoto, T., and Namba, T., (1984), “Mechanism of antihepatotoxic activity of glycerrhizin: effect of free radical generation and lipid peroxidation”, Planta Med., 50, pp. 298–302. Kitteringham, N.R., (1990), “Drug-protein conjugation and its immunological consequences”, Drug Metab Rev., 22, pp. 87–144. Kluger, M.J., (1991), “Fever: Role of pyrogens and cryogens”, Physio. Rev., 71, pp. 93 -127. Knowles, S., Uetrecht, J., and Shear, N., (2000), “Idiosyncratic drug reactions: the reactive metabolite syndrome”, Lancet, 356, pp. 1587–91. Kohlroser, J., Mathai, J., Reichheld, J., Banner, B.F., and Bonkovsky, H.L., (2000), “Hepatotoxicity due to troglitazone: report of two cases and review of adverse events reported to the United States Food and Drug Administration”, Am J Gastroenterol., 95, pp. 272 - 276 . Kon, K., Kim, J.S., Jaeschke, H., and Lemasters, J.J., (2004), “Mitochondrial permeability transition in acetaminophen induced necrosis and apoptosis of cultured mouse hepatocytes”, Hepatology, 40, pp. 1170–1179. Kondo, S., Toyokuni, S., Tsuruyama, T., Ozeki, M., Tachibana, T., and Echizenya, M., (2002), “Peroxynitrite-mediated stress is associated with proliferation of human metastatic colorectal carcinoma in the liver”, Cancer Lett., 179, pp. 87–93. Korourian, S., Hakkak, R., Ronis, M.J.J., Shelnutt, S.R., Waldran, J., IngelmanSundberg, M., and Badger, T.M., (1999), “Diet and risk of ethanol-induced hepatotoxicity: Carbohydrate-fat relationships in rats”, Toxicological Sciences, 47, pp. 110–117. Kroemer, G., and Martin, S.J., (2005), “Caspase-independent cell death”, Nat. Med., 11, pp. 725-730. Kurata, M., Suzuki, M., and Agar, N.S., (1993), “Antioxidant systems and erythrocyte life span in mammals”, Biochem Physiol., 106, pp. 477-487. Lane, P., and Gross, S.S., (1999), “Cell signalling by nitric oxide”, Semin.Nephrol. 19, pp. 215–229. Lasser, K.E., Allen, P.D., Woolhandler, S.J., Himmelstein, D.U., Wolfe, S.M., and Bor, D.H., (2002), “Timing of new black box warnings and withdrawals for prescription medications”, JAMA, 287, pp. 2215-2220. Lawson, J.A., Farhood, A., Hopper, R.D., Bajt, M.L., and Jaeschke, H., (2000), “The hepatic inflammatory response after acetaminophen overdose: role of neutrophils”, Toxicol Sci., 54, pp. 509–516. Le, J., and Vilcek, J., (1987), “Tumor necrosis factor and interleukin-1: Cytokines with multiple overlapping biological activities”, Lab. Invest., 56, pp. 234-248. Lee, E., and Surh, Y.J., (1998), “Induction of apoptosis in HL-60 cells by pungent vanilloids, [6]-gingerol and [6]-paradol”, Cancer Letters, 134, pp. 163–168. Lemasters, J.J., Qian, T., He, L.H., Kim, J.S., Elmore, S.P., Cascio, W.E., and Brenner, D.A., (2002), “Role of mitochondrial inner membrane permeabilization in necrotic cell death, apoptosis, and autophagy”, Antioxid. Redox. Signal., 4, 769 –781. Lewindon, P.J., Pereira, T.N., Hoskins, A.C., Williamson, R.M., Bridle, K.R., Shepherd, R.W., and Ramm, G.A., (2002), “The role of hepatic stellate cells and transforming growth factor-b1 in cystic fibrosis liver disease” Am J Pathol., 160, pp. 1705-1715. Lewis, J.H., (2003), Nonsteroidal anti-inflammatory drugs: pathology and clinical presentation of hepatotoxicity, in: Kaplowitz, N., DeLeve, L.D. (Eds.), DrugInduced Liver Disease, Marcel Dekker, New York, pp. 377–404. Li, H.L., (1998), Plumbaginaceae. In: Flora of Taiwan, vol. IV. Editorial Committee of the Flora of Taiwan. Department of Botany, National Taiwan University, Taipei, pp. 79–82. Li, J., and Billiar, T.R., (1999), “Nitric oxide. IV. Determinants of nitric oxide protection and toxicity in liver”, Am. J. Physiol., 276, pp. G1069–G1073. Lieber, C.S., (1992), Medical and Nutritional Complications of Alcoholism: Mechanisms and Management”, New York, Plenum Press. Lieber, C.S., (2000), “Alcohol and the liver: metabolism of alcohol and its role in hepatic and extrahepatic diseases,” Mount Sinai Journal of Medicine, vol. 67, no. 1, pp. 84–94. Lieber, C.S., (2004), “Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis”, Alcohol, 9, pp. 19. Lieber, C.S., (2005), “Pathogenesis and treatment of alcoholic liver disease: progress over the last 50 years”, Roczniki Akademii Medycznej w Białymstoku, 50, pp. 7 -20. Lieberman, D., and Phillips, D., (1990), “Isolated elevation of alkaline phosphatase: significance in hospitalized patients”, J. Clin. Gastroenterol., 12, pp. 415-9. Lin, S.C., Yao, C.J., Lin, C.C., and Lin, Y.H., (1996), “Hepatoprotective activity of Taiwan folk medicine: eclipta prostrate Linn. against various hapatotoxins induced acute hapatotoxicity”, Phytother Res., 10, pp. 483–90. Liu, Y., Deng, F., Liu, C., Meng, Q.Y., and Gao, Z.W., (2006), “Determination of plumbagin in different parts of Plumbago zeylanica by RP-HPLC”, Zhongguo Zhong Yao Za Zhi., 31, pp. 1684-6. Liu, Z.X., Govindarajan, S., and Kaplowitz, N., (2004), “Innate immune system plays a critical role in determining the progression and severity of acetaminophen hepatotoxicity”, Gastroenterology, 127, pp. 1760–1774. Luper, S., (1998), “A review of plants used in the treatment of liver disease: Part 1”, Alternative Med. Rev., 3, pp. 410–421. Macwan, C., Patel, H. V., and Kalia, K., (2010), “A comparative evaluation of in-vitro antioxidant properties of bamboo bambusa arundinacea leaves extracts”, Journal of Cell and Tissue Research, 10, pp. 2413-2418. Maher J.J., and Bissell D.M., (1993), “Cell–matrix interactions in liver. Semin”, Cell Biol., 4, pp. 189-201. Makena, P.S., and Chung, K.T., (2007), “Effects of various plant polyphenols on bladder carcinogen benzidine-induced mutagenicity”, Food and Chemical Toxicology, 45, pp. 1899–1909. Margetts, P.J., Bonniaud, P., Liu, L., Hoff, C.M., Holmes, C.J., West-Mays, J.A., Kelly, M.M., (2005), “Transient overexpression of TGF- 1 induces epithelial mesenchymal transition in the rodent peritoneum”, J Am Soc Nephrol, 16, pp. 425-436. Martinez, G.L., Diez, R.A., Perez, J.L.S., Gonzalez, C.J., Gil, E.B., and Gutierrez, G.F., (1993), “Tumour necrosis factor, interleukin-1 and interleukin-6 in alcoholic cirrhosis”, Alcohol, 28, pp. 319–323. Masuda, Y., Kikuzaki, H., Hisamoto, M., and Nakatani, N., (2004), “Antioxidant properties of gingerol related compounds from ginger”, Biofactors, 21, pp. 293296. McClain, C.J., and Cohen, D.A., (1989), “Increased tumor necrosis factor production by monocytes in alcoholic hepatitis”, Hepatology, 9, pp. 349–51. McLean, A., (1975), Models of liver diseases. In: Karger, B.A. (Ed.), New Trends in the Therapy of Liver Diseases. S. Karger, Basel, pp. 2–12. Miguez, M.P., Anundi, I., Sainz-Pardo, L.A., and Lindros, K.O., (1994), “Hepatoprotective mechanism of silymarin: no evidence for involvement of cytochrome P450 2E1”, Chem Biol Interact, 91, pp. 51–63. Mitchell, J.R., Jollow, D.J., Potter, W.Z., Davis, D.C., Gillette, J.R., and Brodie, B.B., (1973), “Acetaminophen-induced hepatic necrosis, I: role of drug metabolism”, J Pharmacol Exp Ther., 187, pp. 185 -194. Miyaguchi, S., and Mori, M., (2005), “Ursodeoxycholic acid (UDCA) suppresses liver interleukin 2 mRNA in the cholangitis model”, Hepatogastroenterology, 52, pp. 596-602. Mohamed, N.H., and El-Hadidy, A.M., (2008), “Studies of Biologically Active Constituents of Verbascum eremobium Murb. and its Inducing Resistance against some Diseases of Cucumber”, Egypt. J. Phytopathol., 36, pp. 133-150. Morpurgo, E., Cadrobbi, R., and Morpurgo, M., (1996), “Protective effect of superoxide dismutase and polyethylene glycol-linked superoxide dismutase against renal warm ischemia/reperfusion injury”, Transplantation, 62()9, pp. 1221–1223. Naik, R.S., Mujumdar, A.M., and Ghaskabdi, S., (2004), “Protection of liver cells from ethanol cytotoxicity by curcumin in liver slice culture in vitro”, J Ethnopharmacol, 95, pp. 31–7. Narayana, A., and Subhose, V., (2005), Standardization of Ayurvedic formulations: a scientific review, Bull Indian Inst Hist Med Hyderabad, 35, pp. 21. Natarajan, K.S., Narasimhan, M., Shanmugasundaram, K.R., and Shanmugasundaram, E.R.B., (2006), “Antioxidant activity of a salt-spice-herbal mixture against, free radical induction”, Journal of Ethnopharmacology, 105, pp. 76–83. Nathan, C.J., (1987), “Secretory products of macrophages”, J. Clin. Invest., 79, pp. 319 -326. Nathanson, M.H., and Boyer, J.L., (1991), “Mechanisms and regulation of bile secretion. Hepatology”, 14, pp. 551–566. Nicoll, R., and Henein, M.Y., (2009), “Ginger (Zingiber officinale Roscoe): A hot remedy for cardiovascular disease?”, International Journal of Cardiology, 131, pp. 408-9. Nile, S.H., and Khobragade, C.N., (2010), “Antioxidant activity and flavonoid derivatives of Plumbago zeylanica”, Journal of Natural Products, 3, pp. 130-133 Ohta, H., Okamoto, I., Hanaya, T., and Arai, S., (2006), “Enhanced antioxidant defense due to extracellular catalase activity in Syrian hamster during arousal from hibernation,” Comp. Biol. Physiol., 143, pp. 484-491. Olagunju, J.A., Jobi, A.A., and Oyedapo, O.O., (1999), “An investigation into the biochemical basis of the observed hyperglycaemia in rats treated with ethanol root extract of Plumbago zeylanica”, Phytotherapy Res., 13, pp. 346–348. Packer, L., Witt, E.H., and Tritschler, H.J., (1995), “Alpha-lipoic acid as a biological antioxidant”, Free Radical Biology and Medicine, 19, pp. 227-250. Padmaja, S., and Huie, R.E., (1993), “The reaction of nitric oxide with organic peroxyl radicals”, Biochem. Biophys. Res. Commun., 195, pp. 539–544. Pal, C., Bindu, S., Dey, S., Alam, A., Goyal, M., Iqbal, M.S., Maity, P., Adhikari, S.S., and Bandyopadhyay, U., (2010), “Gallic acid prevents nonsteroidal antiinflammatory drug-induced gastropathy in rat by blocking oxidative stress and apoptosis”, Free Radical Biology and Medicine, 49, pp. 258-267. Park, J.H., Lee, H.J., Koh, S.B, Ban, J.Y., and Seong, Y.H., (2004), “Protection of NMDA-induced neuronal cell damage by methanol extract of Zizyphi Spinosi Semen in cultured rat cerebellar granule cells”, Journal of Ethnopharmacology, 95(1), pp. 39-45. Patel, T., and Gores, G.J., (1997), “Inhibition of bile-salt-induced hepatocyte apoptosis by the antioxidant lazaroid U83836E”, Toxicol. Appl. Pharmacol., 142, pp. 116122. Peng, W.H., Hsieh, M.T., Lee, Y.S., Lin, Y.C., and Liao, J., (2000), “Anxiolytic effect of seed of Ziziphus jujuba in mouse models of anxiety”, Journal of Ethnopharmacology, 72(3), pp. 435-441. Penna, S.C., Medeiros, M.V., Aimbire, F.S.C., Faria-Neto, H.C.C., Sertié, J.A.A., and Lopes-Martins, R.A.B., (2003), “Anti-inflammatory effect of the hydroalcoholic extract of Zingiber officinale rhizomes on rat paw and skin edema”, Phytomedicine, 10, pp. 381–385. Pe´rez, T.R., (1983), “Is cirrhosis of the liver experimentally produced by CCl4 and adequate model of human cirrhosis?”, Hepatology, 3, pp. 112–120. Pigeolet, E., Corbisier, P., Houbion, A., Lambert, D., Michiels, C., and Raes, M., (1990), “Mech Ageing”, Dev., 283, pp. 297. Pimple, B.P., Kadam, P.V., Badgujar, N.S., Bafna, A.R., and Patil, M.J., (2007), “Protective effect of Tamarindus indica Linn against Paracetamol induced hepatotoxicity in rats”, Indian Journal of Pharmaceutical Sciences, 69, pp. 827 -831. !" #$%$ ! # &"'%"'' 0* *1 &"'%"'' ( )* * +',-.%+,-.-++& ( 5 -#*5# /5#"* "# * # / 0 2+++#+3-+& #3 ** +&%/-*-/33 ( * 0 0* # 1 * 4 ! *1 0 + #'Plaa, G.L., and Charbonneau, M., (1989), Detection and evaluation of chemically induced liver injury. In: A.W. Hayes, Editor, Principles and Methods of Toxicology, Raven Press, New York, pp. 399-628. Poli, G., Albano, E., and Dianzani, M.U., (1987), “The role of lipid peroxidation in liver damage”, Chem Phys Lipids, 45, pp. 117–142. Porchezhiana, E., and Ansari, S.H., (2005), “Hepatoprotective activity of Abutilon indicum on experimental liver damage in rats”, Phytomedicine, 12, pp. 62–64. Prajapati, N.D., Purohit, S.S., Sharma, A.K., and Kumar, A., (2003), A Handbook of Medicinal Plants- A complete source book, pp. 410. Prasad, G.C., (1987), “Studies on cancer in Ayurveda and its management”, JRAS, 3, pp. 147-67. Prasad, G.C., and Deshpande, P.J., (1968), “Effect of Rohitaka (Amura rohitaka) on leukaemia”, J Res Indian Med, 3, pp. 36. Prescott, L., Wright, N., Roscoe, P., and Brown, S., (1971), “Plasma paracetamol half-life and hepatic necrosis in patients with paracetamol overdosage”, Lancet, 1, pp. 519–522. Puerta, R.D.L., Martinez, E., Bravo, L., and Ahumada, M.C., (1996), “Effect of silymarin on different acute inflammation models on leukocyte migration”, J. Pharm. Pharmacol., 48, pp. 968-70. Pullaiah, T., (2002), Medicinal Plants in India, 1, Published by Daya Books, pp.64. Rabi, T., and Gupta, R.C., (1995), “Antitumour and cytotoxic investigations of Amura rohitaka”, Int J Pharmacogn, 33, pp. 359–64. Radi, R., Beckman, J., Bush, K. M., and Freeman, B. A., (1991), “Peroxynitrite oxidation of sulfhydryls: the cytotoxic potential of superoxide and nitric oxide”, J. Biol. Chem., 266, pp. 4244–4250. Rajagopal, S.K., Manickam, P., Periyasamy, V., and Namasivayam, N., (2003), “Activity of Cassia auriculata leaf extract in rats with alcoholic liver injury”, J Nutr Biochem, 14, pp. 452–8. Ramm, G.A., Nair, V.G., Bridle, K.R., Shepherd, R.W., Crawford, D.H.G., (1998), “Contribution of hepatic parenchymal and non-parenchymal cells to hepatic fibrogenesis in biliary atresia”, Am J Pathol, 153, pp. 527-535. Ramsay, R.R., Rashed, M.S. and Nelson, S.D., (1989), “In vitro effect of acetaminophen metabolites and analogs on the respiration of mouse liver mitochondria”, Arch. Biochem. Biophys., 273, pp. 449-457. Recknagel, R.O., (1967), “Carbon tetrachloride hepatotoxicity”, Pharm Rev, 19, pp. 145208. Recknagel, R.O., and Malamed, S., (1958), “The osmotic nature of mitochondrial swelling produced by carbon tetrachloride and inorganic phosphate”, J Biol Chem, 232, pp. 705–713. Recknagel, R.O., Lombardi, B., and Schotz, M.C., (1960), “A new insight into pathogenesis of carbon tetrachloride fat infiltration”, Proc Soc Exp Biol Med, 104, pp. 608–610. Recknagel, R.O., Glende, E.A., Dolak, J.A., and Walter, R.L. (1989), “Mechanism of carbon tetrachloride toxicity” Pharmacol Ther., 43, pp. 139-54. Reutov, V.P., and Sorokina, E.G., (1998), “NO-synthase and nitrite-reductase components of nitric oxide cycle”, Biochemistry (Moscow), 63, pp. 874–884. Reynolds, E.S., Thiers, R.E., and Vallee, B.L., (1962), “Mitochondrial function and metal content in carbon tetrachloride poisoning’, J Biol Chem, 237, pp. 3546–3551. Robin, M.A., Roy, M.L., and Descatoire, V., (1997), “Plasma membrane cytochrome P450 as neoantigens and autoimmune targets in drug-induced hepatitis”, J Hepatol, 26, pp. S123–30. Rockey, D.C., and Chung, J.J., (1997), “Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis”, Am. J. Physiol., 273, pp. G124–G130. Rodenas, J., Carbonell, T., and Mitjavila, M.T., (2000), “Different roles for nitrogen monoxide and peroxynitrite in lipid peroxidation induced by activated neutrophils”, Free Radic. Biol. Med., 28, pp. 374–380. Rodrigues, C.M., Ma, X., Stieers, C.L., Fan, G., Kren, B.T., and Steer, C.J., (1999), “Ursodeoxycholic acid prevents cytochrome c release in apoptosis by inhibiting mitochondrial membrane depolarization and channel formation”, Cell Death Differ., 6, pp. 842–854. Rolandi, E., Franceschini, R., Cataldi, A., Cicchetti, V., Carati, L., and Barreca, T., (1991), “Effects of ursodeoxycholic acid (UDCA) on serum liver damage indices in patients with chronic active hepatitis”, A double-blind controlled study. Eur J Clin Pharmacol., 40(5), pp. 473-6. Rolo, A.P., Palmeira, C.M., Holy, J.M., and Wallace, K.B., (2004), “Role of mitochondrial dysfunction in combined bile acid-induced cytotoxicity: the switch between apoptosis and necrosis”, Toxicol. Sci., 79, pp. 196–204. Rolo, A.P., Palmeira, C.M., and Wallace, K.B., (2002), “Interactions of combined bile acids on hepatocyte viability: cytoprotection or sinergism”, Toxicol. Lett., 126, pp. 197-203. Rosa, M.P.G., and Solís, R.V., (2009), “Hepatoprotective and Inhibition of Oxidative Stress in Liver of Prostechea michuacana”, Rec. Nat. Prod., 3(1), pp. 46-51. Rosen, G.M., Singletary W.V., Raukman, E.J., and Killenberg, P.G., (1983), “Acetaminophen hepatotoxicity, an alternative mechanism”, Biochem. Pharmacol., 32, pp. 2053-2059. Rossier, B.C., Geering, K., Kraehenbuhl, J.P., (1987), “Regulation of the sodium pump: how and why?”, Trends. Biol. Sci., 12, pp. 483–487. Rubbo, H., Radi, R., Trujillo, M., Kalyanaraman, B., Barnes, S., Kirk, M., and Freeman, B.A., (1994), “Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation: formation of novel nitrogen-containing oxidized lipid derivatives”, J. Biol. Chem., 269, pp. 20666–20675. Sacchetti, G., Maietti, S., Muzzoli, M., Scaglianti, M., Manfredini, S., Radice, M., and Bruni, R., (2005), “Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods”, Food Chemistry, 91, pp. 621–632. Sakr, S.A., (2007), “Ameliorative Effect of Ginger (Zingiber officinale ) on Mancozeb Fungicide Induced Liver Injury in Albino Rats”, Australian Journal of Basic and Applied Sciences, 1, pp. 650-656. Saller, R., Meier, R., and Brignoli, R., (2001), “The use of silymarin in the treatment of liver diseases”, Drugs, 61, pp. 2035-63. Sallie, R., Tredgeri, J. M., and Willion, R., (1991), “Drugs and the liver”, Biopharmacoutics and Drug Disposition, 12, pp. 251-259. Sankar, R., (1987), “Antilipid Peroxidative efficacy of Plumbagin and menadione: an in vitro study”, Curr. Sci., 56, pp. 890-892. Saraswat, B., Visen, P.K.S., Patnaik, G.K., and Dhawan, B.N., (1999), “Ex-vivo and in vivo investigations of picroliv from Picrorhiza kurroa in an alcohol intoxication model in rats” Journal of Ethnopharmacology, 66, pp. 263–269. Scholmerich, J., Becher, M.S., Schmidt, K., Schubert, R., and Kremer, B., (1984), “Influence of Hydroxylation and conjugation of bile salts on their membrane -damaging properties-Studies on isolated hepatocytes and lipid membrane vesicles”. Hepatology, 4, pp. 661-666. Schulze-Osthoff, K., Beyaert, R., Vandervoorde, V., Haegeman, G., and Fiers, W., (1993), “Depletion of the mitochondrial electron transport abrogates the cytotoxic and gene-induced effects of TNF”, Eu. Mol. Biol. Organ. J., 12, pp. 3095-3104. Senthil, K.R., Viswanathan, P., and Nalini, N., (2003), “Glycine Modulates Hepatic Lipid Accumulation in Alcohol-induced Liver Injury”, Pol J Pharmacol, 55, pp. 603 -611. Setty, S.R., Quereshi, A.A., Swamy, A.H.M.V, Patil, T., Prakash, T., Prabhu, K., and Gouda, A.V., (2007), “Hepatoprotective activity of Calotropis procera flowers against paracetamol-induced hepatic injury in rats”, Fitoterapia, 78, pp. 451–454. Shah, S.N., and Anand, M.P., (2003), API, Text Book of Medicine, 7th edition, Published by The Association of Physicians of India, Mumbai, 625-626. Shahidi, F., and Wanasundara, (1992), P.K.J.P.D.: Crit. Rev. Food Sci.Nutr., 32, pp. 67 -103. Sharma, A., Chakraborti, K.K., and Handa, S.S., (1991), “Antihepatotoxic activity of some plants used in herbal formulation”, Fitoterapia, 62, pp. 131-138. Shen, X., Tang, Y., Yang, R., Yu, L., Fang, T., and Duan, J., (2009)., “The protective effect of Zizyphus jujube fruit on carbon tetrachloride-induced hepatic injury in mice by anti-oxidative activities”, Journal of Ethnopharmacology, 122(3), pp. 555-560. Sheth, S.C., Northover, B.J., Tibrewalla, N.S., Warerkar, U.R., and Karande, V.S., (1960), “Therapy of cirrhosis of liver and liver damage with indigenous drugs”, Experimental and clinical studies, Ind. J. Pediat, 27, pp. 204. Shibayama, Y., Asaka, S., and Nakata, K., (1991), “Endotoxin hepatotoxicity augmented by ethanol”, Exp. Mol. Pathol., 55, pp. 196-202. Shimizu, Y., (1969), “Effect of carbon tetrachloride administration on the synthesis of triglycerides and phospholipids in rat liver, J Lipid Res., 10, pp. 479–486. Sinclair, A.I., Barnett, A.H., and Lennie, J., (1991), “Free radicals and antioxidant system in health and diseases, J Appl. Med, 17, pp. 409. Singh, P., Prakash, L., and Joshi, K.C., (1972), “Lapachol and other constituents from the bignoniaceae, Phytochemistry, 11(4), pp. 1498. Sipes, I. G., Krishna, G., and Gillette, J. R., (1974), “Bioactivation of carbon tetrachloride, chloroform and bromotrichloromethane: Role of cytochrome P450”, Life Sci., 20, pp. 1541–1548. Skou, J.C., (1965), “Enzymatic basis for active transport of Na+ and K+ across cell membrane”, Physiol. Rev., 45, pp. 596-617. Skou, J.C., Butler, K.W., and Hansen, O., (1971), “The effect of magnesium, ATP, Pi, and sodium on the inhibition of the (Na+ K+)-activated enzyme system by g -strophanthin”, Biochim. Biophys. Acta, 241, pp. 443-461. Sokol, R.J., McKim Jr., J.M., Goff, M.C., Ruyle, S.Z., Devereaux, M.W., Han, D., Packer, L., and Everson, G., (1998), “Vitamin E reduces oxidant injury to mitochondria and the hepatotoxicity of taurochenodeoxycholic acid in the rat”, Gastroenterology, 114, pp. 164–174. Sokol, R.J., Winklhofer-Roob, B.M., Devereaux, M.W., and McKim, J.M., (1995), “Generation of hydroperoxides in isolated rat hepatocytes and hepatic mitochondria exposed to hydrophobic bile acids”, Gastroenterology, 109, pp. 1249-1256. Song, Y., Ding, H., and Mong, S., (2006), Protective Effects of The Effective Parts of Zingiber officinale on Ecv-304 Cells Oxidative Stress Injury induced by Hydrogen Peroxide in Vitro, Poster Session P7 Basic science (lst part), TuP7, pp. 137. Sonnenbichler, J., and Zetl, I., (1986), “Biochemical effects of the flavolignane silibinin on RNA, protein and DNA synthesis in rat liver”, Prog. Clin. Biol. Res., 213, pp. 319–331. Stoilova, I., Krastanov, A., Stoyanova, A., Denev, P., and Gargova, S., (2007), “Antioxidant activity of a ginger extract (Zingiber officinale), Food Chemistry, 102, 764–770. Straat, V.D., Vermeulen, N.P.E., Bessems, J.G.M., (1992), “Molecular aspect of paracetamol-induced hepatotoxicity and its mechanism based prevention”, Drug Metab. Rev., 24, pp. 367. Subbarao, V.V., and Gupta, M.L., (1978), “Effect of Carbon tetrachloride and Liv.52 on Liver Microsomal Protein, Total Protein and Nucleic Acids”, The Indian Practitioner, 11, pp. 831. Subehan, Usia, T., Iwata, H., Kadota, S., and Tezuka, Y., (2006), “Mechanism-based inhibition of CYP3A4 and CYP2D6 by Indonesian medicinal plants, Journal of Ethnopharmacology”, 105, pp. 449–455. Surh, Y.J., Chun, K.S., Cha, H.H., Han, S.S., Keum, Y.S., Park, K.K., and Lee, S.S., (2001), “Molecular mechanisms underlying chemopreventive activities of antiinflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-kappa B activation”, Mutat. Res., 480-481, pp. 243–268. Tanaka, E., Terada, M., and Misawa, S., (2000), “Cytochrome P4502E1: its clinical and toxicological role”, J. Clin. Pharm. Ther., 25, pp. 165: 175. Temple, R.J., and Himmel, M.H., (2002), “Safety of newly approved drugs: implications for prescribing”, JAMA, 287, pp. 2273-2275 . Terao, J., Asano, I., and Matsushita, S., (1984), “High-performance liquid chromatographic determination of phospholipid peroxidation products of rat liver after carbon tetrachloride administration”, Arch Biochem Biophys, 235, pp. 326 -333. Testa, B., and Jenner, P., (1981), “Inhibition of cytochrome P-450s and their mechanism of action”, Drug Metabolism Review, 12, pp. 1-17. Thames, G., (2004), “Drug-induced liver injury: what you need to know. Gastroenterol Nurs., 27, pp. 31-33. Thiers, R.E., and Reynolds, E.S., (1958), “Effects of carbon tetrachloride intoxication on distribution of metals in subcellular fractions of rat liver”, Fed. Proc., 17, pp. 537. Thomson, M., Al-Qattan, K.K., Al-Sawan, S.M., Alnaqeeb, M.A., Khan, I., and Ali, M., (2002), “The use of Ginger (Zingiber officinale Rosc.) as a potential antiinflammatory and antithrombotic agent”, Prostaglandins, Leukotrienes and Essential Fatty Acids, 67, pp. 475-478. Tilak, J.C., Adlikari, S., and Devasagayam, T.P.A., (2004), “Antioxidant properties of P. zeylanica, an Indian medicinal plant and its active ingredient, plumbagin”, Redox Report, 9, pp. 219–227. Tirmenstein, M.A., and Nelson, S.D., (1989), “Subcellular binding and effects on calcium homeostasis produced by acetaminophen and a non hepatotoxic regioisomer, 3'hydroxyacetanilide, in mouse liver”, J. Biol. Chem., 264, pp. 9814. Tjendraputra, E., Ammit, A.J., Roufogalis, B.D., Tran, V.H., and Duke, C.C., (2003), “Effective anti-platelet and COX-1 enzyme inhibitors from pungent constituents of ginger”, Thrombosis Research, 111, pp. 259–265. Tjendraputra, E., Tran, V.H., Liu-Brennan, D., Roufogalis, B.D., and Duke, C.C., (2001), “Effect of Ginger Constituents and Synthetic Analogues on Cyclooxygenase-2 Enzyme in Intact Cells”, Bioorganic Chemistry, 29, pp. 156–163. Tokunaga, T., Takadab, N., and Uedaa, M., (2004), “Mechanism of anti-feedant activity of plumbagin, a compound concerning the chemical defense in carnivorous plant”, Tetrahedron Letters, 45, pp. 7115–7119. Tomasi, A., Albano, E., Lott, K.A.K., Slater, T.F., (1980), “Spin trapping of free radical products of CCl4 activation using pulse radiolysis and high energy radiation procedures”, FEBS Lett., 122, pp. 303-306. Tome, S. and Lucey, M.R., (2004), “Review article: current management of alcoholic liver disease”, Alimentary Pharmacology and Therapeutics, 19, 7, pp. 707–714. Toniutto, P., Fabris, C., Bitetto, D., Fornasiere, E., Fumolo, E., Rapetti, R., and Pirisi, M., (2008), “Antiviral treatment in patients with hepatitis C virus-related cirrhosis awaiting liver transplantation”, Ther Clin Risk Manag, 4(3), pp. 599–603. Tsatsanis, C., Androulidaki, A., Venihaki, M., and Margioris, A.N., (2006), “Signalling networks regulating cyclooxygenase-2”, Int. J. Biochem., Cell Biol. 38, pp. 1654 –1661. Tsukamoto, H., (1998), “Animal models of alcoholic liver injury”, Clinics in Liver Disease, 2(4), pp. 739-752. Tsukamoto, H. and Xi, X.P., (1989), “Incomplete compensation of enhanced hepatic oxygen consumption in rats with alcoholic centrilobular liver necrosis”, Hepatology, 9, pp. 302–306. Ueno, H., Kawai, M., Shimokawa, H., Hirota, M., Ohmi, M., Sudo, R., Ohta, A., Arano, Y., and Hattori, K., (2009), “Synthesis and structure-activity relationships of oxamyl dipeptide caspase inhibitors developed for the treatment of liver disease”, Bioorg Med Chem Lett., 19(1), pp. 199-202. Varela-Moreiras, G., Alonso-Aperte, E., Rubio, M., Gasso, M., Deulofeu, R., Alvarez, L., Caballeria J, Rodes J, and Mato, J.M., (1995), “Carbon tetrachloride-induced hepatic injury is associated with global DNA hypomethylation and homocysteinemia: effect of S-adenosylmethionine treatment”, Hepatology, 22, pp. 1310–1315. Vendruscolo, A., Takaki, I., Bersani-Amado, L.E., Dantas, J.A., Bersani-Amado, C.A., and Cuman, R.K.N., (2006), “Anti-inflammatory and antinociceptive activities of Zingiber officinale Roscoe essential oil in experimental animal models”, Indian J Pharmacol, 38, pp. 58-59. Venukumar, M.R., and Latha, M.S., (2002), “Antioxidant activity of Curculigo orchioides in carbon tetrachloride-induced hepatopathy in rats”, Indian J. Clin. Biochem, 17, pp. 80-87. Verma, K.S., Jain, A.K., and Gupta, S.R., (1986), “Structure of undulatin: New iridoid glycosides from Tecomella undulate”, Planta Medica, 52, pp. 359–362. Vermeulen, N.P.E., Bessems, J.G.M., and Van-de-Streat, R., (1992), “Molecular aspects of paracetamol induced hepatotoxicity and its mechanism based prevention”, Drug Metabolism and Review, 24, pp. 367-407. Vijver, L.M.V., and Lotter, A.P., (1971), “The constituents in the roots of Plumbago auriculata LAM and Plumbago zeylanica L. responsible for antibacterial activity”, Planta Medica, 22, pp. 8–13. Vos, T.A., Goor, H., Tuyt, L., Jager-Krikken, A., Leuvenink, R., Kuipers, F., Jansen, P. L., and Moshage, H., (1999), “Expression of inducible nitric oxide synthase in endotoxemic rat hepatocytes is dependent on the cellular glutathione status”, Hepatology, 29, pp. 421-426. Wagner, H., (1981), Plant constituents with anti-hepatotoxic activity. In: Beal J.L., Reinhard, E., editors. Natural Hippokrates-Verlag, pp. 462-465. Products as Medicinal Agents. Stuttart: Wagner, H., Diesel, P., and Seitz, M., (1974), “The chemistry and analysis of silymarin from Silybum marianum”, Gaertn Arzneimittelforsch, 24, pp. 466–471. Wang, S.Y., (2000), “Antioxidant Activity in Fruits and Leaves of Blackberry, Raspberry,and Strawberry Varies with Cultivar and Developmental Stage, J. Agric. Food Chem. 48, pp. 140-146. Wang, J.F., Greenberg, S.S., and Spitzer, J.J., (1995), “Chronic alcohol administration stimulates nitric oxide formation in rat liver with or without pretreatment by lipopolysaccharide”, Alcohol Clin Exp Res, 19, pp. 387-393. Wang, R., Kong, J., Wang, D., Lien, L.L., and Lien, E.J., (2007), “A survey of Chinese herbal ingredients with liver protection activities”, Chin. Med., 10, pp. 5. Wang, Y., Singh, R., and Lefkowitch, J.H., (2006), “Tumor necrosis factor-induced toxic liver injury results from JNK2-dependent activation of caspase-8 and the mitochondrial death pathway”, J. Biol. Chem., 281, pp. 15258–15267. Watanabe, N., Suzuki, J., and Kobayashi, Y., (1996), “Role of calcium in tumor necrosis factor- produced by activated macrophages”, J. Biochem., 120, pp. 1190-1195. Wills, E.D., (1966), “Mechanisms of Lipid Peroxide Formation in Animal Tissues”, Biochem. J., 99, pp. 667. Wink, D.A., and Mitchell, J.B., (1998), “Chemical biology of nitric oxide: insights into regulatory, cytotoxic, and cytoprotective mechanisms of nitric oxide”, Free Radic. Biol. Med., 25, pp. 434–456. Wink, D. A., Osawa, Y., Darbyshire, J. F., Hones, C. R., Eshenaur, S.C., Nims, R.W., (1993), “Inhibition of cytochromes P450 by nitric oxide and a nitric oxide releasing agent”, Arch. Biochem. Biophys. 300, pp. 115–123. Wong, L., Yamasaki, G., Johnson, R.J., and Friedman, S.L., (1994), “Induction of betaplatelet-derived growth factor receptor in rat hepatic lipocytes during cellular activation in vivo and in culture”, J Clin Invest, 94, pp. 1563–1569. Worman, H.J., (1997), “Molecular biological methods in diagnosis and treatment of liver diseases”, Clinical Chemistry, 43, pp. 1476-1486. Yacout, G.A., Elguindy, N.M., and El-Azab, E.F., (2007), “Amelioratic Effect of Zingiber Officinale on Experimentally Induced Liver Fibrosis in Rats”, Journal of Medical Research Institute, 28, pp. 154 -59. Yang, S., and Yu, C., (2008), “Antiinflammatory effects of Bu-zhong-yi-qi-tang in patients with perennial allergic rhinitis”, Journal of Ethnopharmacology, 115(1), pp. 104-109. Yanpallewar, S.U., Sen, S., Tapas, S., Kumar, M., Raju, S.S., and Acharya, S.B., (2002), “Effect of Azadirachta indica on paracetamol-induced hepatic damage in albino rats”. Phytomedicine, 9, 391–396. Yemitan, O.K., and Izegbu, M.C., (2006), “Protective effects of Zingiber officinale (Zingiberaceae) against carbon tetrachloride and acetaminophen-induced hepatotoxicity in rats”, Phytotherapy Research, 20, pp. 997–1002. Yin, M., Wheeler, M.D., Kono, H., Bradford, B.U., Gallucci, R.M., Luster, M.I., and Thurman, R.G., (1999), “Essential role of tumor necrosis factor alpha in alcohol -induced liver injury in mice”, Gastroenterology, 117, pp. 942–952. Yoon, S.O., Yun, C.H., and Chung, A.S., (2002), “Dose effect of oxidative stress on signal transduction in aging”, Mech. Ageing Dev., 123, pp. 1597–1604. Zancan, K.C., Marcia, O.M.M., Ademir, J.P., and Angela, A.M., (2002), “Extraction of ginger (Zingiber officinale Roscoe) oleoresin with CO2 and co-solvents: a study of the antioxidant action of the extracts”, Journal of Supercritical Fluids, 24, pp. 57–76. Zhao. D., and Hirst. B.H., (1991), “Prostaglandin protects against bile salt induced increases in Proton permeation of duodenal brush border membrane”, Gut., 32, pp. 645–648. Zhu, Y.Z., Huang, S.H., Tan, B.K.H., Sun, J., Whiteman, M., and Zhu, Y.C., (2004), “Antioxidants in Chinese herbal medicines: a biochemical perspective”, Nat. Prod. Rep. 21, pp. 478–489. Zima, T., and Kalousova, M., (2005), “Oxidative Stress and Signal Transduction Pathways in Alcoholic Liver Diseases, Alcoholism: Clinical and Experimental Research”, 29, pp. 110S-115S. Zimmerman, H.J., (1999), Drug-induced liver disease. In: Zimmerman H.J., ed. Hepatotoxicity: The Adverse Effects of Drugs and Other Chemicals on the Liver. 2nd ed. Philadelphia, PA: Lippincott Williams & Wilkins, pp. 427-456.