Interplay between self-associates and templates

ISIC19 PROGRAMME
WEDNESDAY September 17th, 2014
8:20 - 8:40 Opening Session
Wed 8:40 - 10:20 PLENARY SESSION 1
Fundamentals of Crystallization Science
Invited : Allan S. Myerson
Massachusetts Institute of Technology
Heterogeneous nucleation: The role of surface structure and chemistry
282 – The impact of desolvation and molecular pre-assembly on the crystal nucleation kinetics of
benzoic and p-aminobenzoic acids
R.A. Sullivan1, R.J. Davey1*, G. Sadiq1, G. Dent1, K. R. Back1, J. H. ter Horst2 , D.Toroz3 and R. B.
Hammond3
1. School of Chemical Engineering and Analytical Science, University of Manchester M13 9PL, UK; 2.
Intensified Reaction & Separation Systems, Delft University of Technology, Delft, The Netherlands; 3
Institute of Particle Science and Engineering, University of Leeds, Leeds LS2 9J, UK
213 – About fluid inclusions and morphological transitions in organic and ionic crystals
S. Petit1, C. Brandel1, A. Waldschmidt1, G. Gouhier2, Y. Cartigny1, G. Coquerel1
1Crystal
Genesis Unit, Laboratoire SMS – EA3233, Université de Rouen
6014, FR 3038, INSA Rouen, CNRS, IRCOF, Université de Rouen
Normandie Université, 76821 Mont Saint-Aignan Cedex, FRANCE
2 COBRA, UMR
187 – Insights into the Nucleation of Organic Molecules from Metadynamics Simulations
M. Salvalaglio1,3, F. Giberti2,3, M. Mazzotti1, M. Parrinello2,3
1Institute
of Process Engineering, ETH Zurich
of Chemistry and Applied Biosciences, ETH Zurich Switzerland
3Facolta di Informatica, Istituto di Scienze Computazionali, Università della Svizzera Italiana Switzerland
2Department
10:20 - 10:50 Coffee Break
PARALLEL SESSIONS 1
Wed 10:50 - 12:10 Fundamentals of Crystallization Science
350 – Polymorph Nucleation: Interplay between self-associates and templates
Samir A. Kulkarnia, Cameron Weberb, Allan Myersonb, and Joop H. ter Horsta
a Delft University of Technology, Intensified Reaction & Separation Systems, Process & Energy Laboratory,
Leeghwaterstraat 44, 2628CA Delft, The Netherlands. ([email protected])
b Department of Chemical Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue
66-568, Cambridge, MA 02139, USA.
248 – Coupling Droplet Microfluidic and Small Angle X-Ray Scattering : Toward on-line
measurement of the first nucleation step
N. V. Pham1, F. Bonneté2, M. E. Brennich3, A. Round4,5, P. Pernot3, E. Cid1, B. Biscans1, S. Teychené1
1 Université
de Toulouse, CNRS, INPT, UPS ; Laboratoire de Génie Chimique UMR 5503; 4, Allée Emile Monso,
F-31030 Toulouse, France
2 Institut des Biomolécules Max-Mousseron, UMR 5247, faculté des sciences d Avignon, 33, rue Louis-Pasteur,
84000 Avignon, France
3 European Synchrotron Radiation Facility, 6 Rue Jules Horowitz, 38000 Grenoble, France
4 European Molecular Biology Laboratory, Grenoble Outstation,, 6 rue Jules Horowitz, 38042, France
5Unit for Virus Host-Cell Interactions, Univ. Grenoble Alpes-EMBL-CNRS, 6 rue Jules Horowitz, 3804,2 France.
309 – Populations and size distributions of solute-rich mesoscale structures in aqueous amino acid
solutions and their role in crystal nucleation
A. Jawor-Baczynska1, B.D. Moore2, J. Sefcik1
1EPSRC
Centre for Innovative Manufacturing in Continuous Manufacturing and Crystallisation, Department
of Chemical and Process Engineering, University of Strathclyde, Glasgow, UK ;
2WestCHEM, Department of Pure and Applied Chemistry, University of Strathclyde, Glasgow, UK
165 – A versatile microfluidic approach to crystallization
Zhang S., Ferté N., Candoni N. and Veesler S
CNRS, CINaM, Aix-Marseille Université Campus de Luminy, Case 913, 13288 Marseille Cedex 09, France
Wed 10:50 - 12:10 Process Design, Scale-up and Downstream Processing
250– Solvent-Aided Layer Crystallization – Case Study Glycerol-Water
F. J. Eisenbart, J. Ulrich
Martin-Luther-Universität Halle-Wittenberg; Zentrum für Ingenieurwissenschaften; Thermische
Verfahrenstechnik D-06099 Halle GERMANY
228 – Crystallization-enhanced enzymatic synthesis of β-lactam antibiotics
L. Encarnación-Gómez1, A. S. Bommarius1, and R.W. Rousseau1
1 School of Chemical and Biomolecular Engineering
Georgia Institute of Technology
Atlanta, GA 30332-0100, USA
324 – Experimental Screening Method for Flash Crystallization
Jörn Gebauer, Matthias Kind
Karlsruhe Institute of Technology, Institute of Thermal Process Engineering
Kaiserstraße 12, 76131 Karlsruhe, GERMANY
130 – Using crystallization technology improves the after-processing properties of active
pharmaceutical ingredients
A. Songgu Wu1, 3, B. Weiqiang Dun2,3, C. Qi Wang2, D. Junbo Gong 2, 3,4,
1 Fang yuan of Tianjin university industrial crystallization technology Co. Ltd, Tianjin300462, People’s
Republic of China;
2 School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin
University, Tianjin300072, People’s Republic of China;
3 The Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin, Tianjin University
4 Tianjin Key Laboratory of Modern Drug Delivery and High Efficiency, Tianjin University,
Wed 10:50 - 12:10 Characterization Techniques of Crystals and Suspensions
347 – Para-aminobenzoic acid in solution and in its crystal polymorphs: experimental studies of
molecular conformation by N K-edge core level spectroscopies
Adrian Gainar1, Joanna S. Stevens1, Edlira Suljoti2, Jie Xiao2, Ronny Golnak2, Tim Brandenburg2,
Emad F. Aziz2 & Sven L. M. Schroeder1,3
1The
University of Manchester, School of Chemical Engineering and Analytical Science, The Mill, Sackville
Street, Manchester, M13 9PL, UNITED KINGDOM
2Helmholtz-Zentrum Berlin, Department Structure and Dynamic of Functional Material in Solution, AlbertEinstein-Str. 15, 12489 Berlin, GERMANY
3The University of Manchester, School of Chemistry, Brunswick Street, Manchester, M13 9PL, UNITED
KINGDOM
296 – Nephelometric measurements to investigate the influence of nucleation and growth kinetics
on the evolution of new born crystals
M. Parisi1, V.K. Tchieda2, A. Chianese1
1Università
degli Studi di Roma La Sapienza - Dipartimento di Ingegneria Chimica Materiali Ambiente;
Via Eudossiana 18, 00184 Roma ITALY
1Laboratory of Analytical Chemistry, Faculty of Science, University of Yaoundé 1 ;
P.O Box 812 Yaoundé, CAMEROON
128 – Characterization and Structure Analysis of Novel Mixed Crystals in Co-crystallization of
Disodium 5'-inosinate and Disodium 5'-guanylate from Water + Ethanol Mixtures
Zengkun Liu, Qiuxiang Yin, Hui Zhang, Junbo Gong
School of Chemical Engineering & Technology, State Key Laboratory of Chemical Engineering, Tianjin
University; Tianjin 300072, People’s Republic of China
160 – Study on the solubility and crystal growth of MgCl2-6H2O-C4H8O2
Miaomiao Jin1,2, Patrick Frohberg2, Yuzhu Sun1, Ping Li1, Jianguo Yu1, Joachim Ulrich2 1: 1
State Key laboratory of Chemical Engineering, East China University of Science and Technology,
Shanghai 200237, China
2 Martin-Luther-Universität Halle-Wittenberg, Zentrum für Ingenieurwissenschaften,
Verfahrenstechnik/ TVT, 06099 Halle, Germany
Wed 12:10 - 13:30 Lunch
Wed 13:30 - 15:00 Coffee Break + Poster session A
Wed 15:00 - 16:20 PLENARY SESSION 2
Characterization of Crystals and Suspensions
Invited: Robert Botet
Laboratoire de Physique des Solides d'Orsay, Paris France
Self-organized aggregation – The numerics legacy
223 – Shape Identification of Primary Particles in Crystal Aggregates
T. Kovačević1, A. Reinhold1, H. Briesen1
1Technische
Universität München; Chair for Process Systems Engineering;
Gregor-Mendel-Straße 4 , 85354 Freising, GERMANY
129 – Precipitation kinetics of barium sulfate at high supersaturation by in-situ synchrotron
radiation WAXS
R. Kügler1, S. Doyle2, M. Kind1
1Karlsruhe
Institute of Technology, Institute of Thermal Process Engineering
Kaiserstraße 12, 76137 Karlsruhe GERMANY
Wed 16:20 - 16:50 Coffee Break
PARALLEL SESSIONS 2
Wed 16:50 - 18:30 Fundamentals of Crystallization Science
249 – Determining solubility through solvent addition
M.A. Reus1, A.E.D.M. van der Heijden1,2, J.H. ter Horst1
1 Delft
University of Technology, Intensified Reaction and Separation Systems, Delft, 2628 CA, The
Netherlands;
2 TNO Technical Sciences, Department of Energetic Materials, Rijswijk, 2280 AA, The Netherlands
244 – Applying Thermodynamics for Crystallization Process Design in a Mixture where Oiling Out
occurs
Ian de Albuquerque and Marco Mazzotti
ETH Zurich, SPL;
Sonneggstrasse 3, 8092 Zurich SWITZERLAND
126 – Crystallization and phase transformation of protein crystals: A case study of lysozyme
X. Yu1,2, J. Wang2, J. Ulrich1
1
Martin-Luther-Universtät Halle-Wittenberg, Zentrum für Ingenieurwissenschaften,
Verfahrenstechnik / TVT, D-06099 Halle, Germany;
2 Tianjin University, School of Chemical Engineering and Technology,
State Key Laboratory for Chemical Engineering, 300072 Tianjin, PR China
232 – Rationale for Selection of Experiment Conditions for Polymorph Isolation in Piracetam
Anthony Maher, Colin C. Seaton , Denise M. Croker , Åke C. Rasmuson , and Benjamin K. Hodnett
Synthesis and Solid State Pharmaceuticals Centre, Materials and Surface Science Institute
and the Department of Chemical and Environmental Sciences,
University of Limerick, Limerick, Ireland
156 – Metastable zone width of lovastatin in different solvent
Xiang-Yang Zhang1, Gang Qian1, Shanshan Liang1, Xing-Gui Zhou1
1State
Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai
Wed 16:50 - 18:30 Process Design, Scale-up and Downstream Processing
304 – Desalination of Reverse Osmosis Retentate by Suspension Crystallisation
M. Ahmad1, S. Dette2
1Kuwait
Institute for Scientific Research, Water Research Center,
P.O. Box 24885, Safat 13109, Kuwait, [email protected].
2Sulzer Chemtech Ltd, Sulzerallee 48, P.O. Box 65,
CH-8404 Winterthur, Switzerland,
174 – Industrial crystallization of ammonium sulphate from solution after ammonia water FGD
proces
Piotr Maria Synowiec1,2 , Barbara Bunikowska1
1Fertilizer Research Institute, Division of Inorganic Chemistry ul. Sowińskiego 11, 44-101 Gliwice,
Poland
2Silesian
POLAND
University of Technology, Chem. Eng. & Process Design. Dept., ul. Strzody 7, 44-100 Gliwice,
218 – Flexible continuous preferential crystallization processes using wet mills for in-situ
generation
T. Vetter1,2, C.L. Burcham1, M.F. Doherty2
1Eli
Lilly & Company, Indianapolis, IN-46281, United States
of Chemical Engineering, University of California, Santa Barbara, CA-93106, United States
2Department
168 – Recovery of fermentation products by a novel electrochemically induced crystallization
process
R.J.M. Bisselink1, C.A. Roa Engel2, J. van Erkel1, J.H. Urbanus2, C.P.M. Roelands2, D. Verdoes2
1TNO;
Water treatment Department,
Utrechtseweg 48, 3704 HE, Zeist The Netherlands
2TNO; Process & Instrumentation Development Department,
Leeghwaterstraat 46, 2628 JA, Delft The Netherlands
269 – Controlling the nucleation of lysozyme and enhancing its nucleation window by seeding with
inorganic nanoparticles
U.Weichsel1, D. Segets1, W. Peukert1
1Institute
of Particle Technology, University of Erlangen-Nuremberg, Germany
Wed 16:50 - 18:30 Characterization Techniques of Crystals and Suspensions
204 – Measurement and Modelling of Shape and Agglomeration of β L-Glutamic Acid
D. Ochsenbein1, S. Schorsch2, T. Vetter3, M. Mazzotti2 and M. Morari11: ETH Zürich, Switzerland; 2: 1
ETH Zurich; IfA; Physikstrasse 3, 8092 Zurich, SWITZERLAND
2ETH Zurich; SPL; Sonneggstrasse 3, 8092 Zurich, SWITZERLAND
3University of California Santa Barbara; Dept. Chem. Eng., 93106 Santa Barbara, USA
189 – Determination of agglomeration degree distribution of crystals using image analysis
L.-M. Terdenge, S. Heisel, G. Schembecker, and K. Wohlgemuth
TU Dortmund University; Laboratory of Plant and Process Design
Emil-Figge-Straße 70, 44227 Dortmund GERMANY
327 – Effect of mixing on phase formation and morphology of nanocrystalline boehmite prepared
by precipitation
S. Kirchner1,2, S. Teychené1, C. Frances1, M. Boualleg2, A. Dandeu2, B. Biscans1
1Université de Toulouse ; CNRS, LGC ; UMR 5503
4 allée Emile Monso, BP 84234, 31342 Toulouse Cedex 4 France
2IFP Énergies nouvelles ;
Rond-point de l’échangeur de Solaize, BP3, 69360 Solaize France
227 – Development of a new X-Ray diffractomer in a reflection mode -q/-q for in situ
characterization during crystallization processes.
A. Lafontaine, Y. Cartigny, M. Sanselme, G. Coquerel
Crystal genesis Unit, SMS EA 3233, Normandie Université, IMR 4114
76821 Mont Saint Aignan Cedex - FRANCE
312 – Link between the ATR-UV/Vis signal of zwitterionic solutions and the polymorphic outcome
in cooling crystallization
E. Simone1, A.N. Saleemi1, Z.K. Nagy2
1Department
2School
of Chemical Engineering, Loughborough University, Loughborough, LE11 3TU, UK
of Chemical Engineering, Purdue University, West Lafayette, IN 47907-2100, USA
Wed 19:00 Working Party Meeting: on Invitation
THURSDAY September 18th, 2014
8:30 - 10:10 PLENARY SESSION 3
Process Design, Scale-up and Downstream Processing
Invited : Daniele Marchisio
Politecnico di Torino
Population balance modeling coupled with computational fluid dynamics
for crystallization: possibilities, limitations and open challenges
277 – Supersaturation Control during Fractional Crystallization
Daniel J. Griffin1, Martha A. Grover1, Yoshiaki Kawajiri1, Ronald W. Rousseau1
1Georgia Institute of Technology
311 Ferst Drive NW, Atlanta, GA 30332-0100
314 – Control of crystal shape by using crystal growth modifiers
A. Borsos1, A. Majumder1, Z. K. Nagy1,2
1: Loughborough University, United Kingdom; 2: Purdue University, United States of America
238 – Intensification of falling film melt crystallization process through microstructured surfaces
M. Le Page Mostefa1, H. Muhr1, E. Plasari1, M. Fauconet2
1
Laboratory of Reactions and Process Engineering (LRGP) – CNRS Lorraine University
1, rue Grandville BP 20451; 54001 Nancy Cedex France
2
ARKEMA Centre R&D de l’Est
CRDE – BP 61005 ; 57501 Saint-Avold Cedex France
Thu 10:10 - 10:40 Coffee Break
PARALLEL SESSIONS 3
Thu 10:40 - 12:00 Fundamentals of Crystallization Science
330 – Emulsion crystallisation as a route to chiral enrichment: Threonine and R,S-2-Chloromandelic
Acid
S. Gilks [1], R. Davey [1], G. Sadiq [1], R. Mughal.
[1] School of Chemical Engineering and Analytical Science, The University of Manchester, Sackville Street,
Manchester, M13 9PL, UK
226 – Crystallization-in-emulsion process: obtaining primary nucleation rates thanks to in situ
video monitoring in a stirred reactor
T. Htira1, E. Gagnière1, A. Khalil1, J.M. Galvan2, A. Rivoire1, J.P. Valour1, F. Puel1
1
Université Lyon 1, LAGEP UMR5007, CPE-Lyon, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France
Lyon 1, INL UMR5270, 3 rue Victor Grignard, CPE-Lyon, Villeurbanne, France
2Université
276 – Quality Control of Organic Crystalline Particles in Anti-Solvent Crystallization by Using
Ternary Phase Diagram
H. Takiyama, N. Kaneko, W.Y. Lee
Tokyo University of Agriculture and Technology (TUAT);
24-16, Nakacho-2, Koganei, Tokyo 184-8588 JAPAN
328 – Contribution to the understanding of the putative NPLIN polarization switching mechanism
through crystalization of carbamazepine, sulfathiazole and glycine
A. Spasojevic-de Biré*1,2, A. Ikni1,2, W. Li1,2, B. Clair1,2, P. Scouflaire1,3, N. El Hassan1,2, J-M. Gillet1,2
1Ecole
Centrale Paris;
UMR 8580 Laboratoire « Structures, Propriétés et Modélisation des Solides » (SPMS);
2 CNRS, UPR 288, Laboratoire « Energétique Moléculaire et Macroscopique, Combustion » (EM2C);
Grande Voie des Vignes, 92295 Châtenay-Malabry Cedex FRANCE
1CNRS,
Thu 10:40 - 12:00 Process Design, Scale-up and Downstream Processing
245 – A digital microfluidic approach to study very high nucleation rates involved in precipitation
processes
Y. Vitry1, S. Teychené1, S. Charton2, G. Borda2, B.Biscans1
1 Université
de Toulouse ; CNRS, INPT, UPS ; Laboratoire de Génie Chimique UMR 5503; 4, Allée Emile Monso,
F-31030 Toulouse, France
2CEA, DEN, DTEC, SGCS, F–30207 Bagnols-sur-Cèze, France
181 – Experimental study on the uranium peroxide precipitation in a fluidized-bed reactor
L. Mojica1, M. Bertrand1, J. Gaillard1, F. Auger2, H. Muhr3, E. Plasari3
1CEA
Marcoule, DEN, RadioChemistry & Processes Department; B.P. 17171,30207 Bagnols-sur-Cèze, France
Mines / SEPA; 87250 Bessines-sur-Gartempe, France
3National High School of Chemical Industries, Reactions and Process Engineering Laboratory, University of
Lorraine, CNRS 1 rue Grandville, BP 20451, 54001 Nancy, France
2Areva
345 – Application of continuous eutectic freeze crystallization to multicomponent brines
D. Ndoro, M. Rodriguez Pascual, A. E. Lewis
University of Cape Town; Private Bag X3, Rondebosch 7701, Cape Town, South Africa
201 – Investigating the Size Dependent Growth Rates of β L-Glutamic Acid using Imaging Tools
S. Schorsch2, D. Ochsenbein1, T. Vetter2,3, M. Morari1 and M. Mazzotti2
1
ETH Zurich; IfA; Physikstrasse 3, 8092 Zurich, SWITZERLAND
Zurich; SPL; Sonneggstrasse 3, 8092 Zurich, SWITZERLAND
3Current Affiliation: University of California Santa Barbara; Dept. Chem. Eng., 93106 Santa Barbara, USA
2ETH
Thu 10:40 - 12:00 Product Engineering
180 – Composite Alginate Hydrogel Laden with Crystalline Active Pharmaceutical Ingredients of
Controlled Size
H.B. Eral1, M. O’Mahony1, B. L. Trout1, A.S. Myerson1, P.S. Doyle1
1 MIT-Novartis Center for Continuous Manufacture, Department of Chemical Engineering, Massachusetts
Institute of Technology, 77 Massachusetts Ave, Cambridge, MA 02138. U.S.A.
265 – Manufacturing of composites by supercritical precipitation in porous materials. Application
to orthopaedic prosthesis
M.P Fernández-Ronco1, J. Kluge1, J. Krieg2, S. Rodríguez-Rojo1, B. Andreatta2, R. Luginbuehl2, M.
Mazzotti1, J. Sague2
1Institute
2RMS
of Process Engineering. ETH Zurich; Sonneggstrasse 3, 8092 Zurich, SWITZERLAND
Foundation, Bischmattstrasse 12, 2544 Bettlach, SWITZERLAND
149 - Preparation of composite particles comprised of antifungal drug and new additive agent for
dry powder inhalation by crystallization during spray drying
K. Kadota1, T. Nishimura1, D. Hotta1 and Y. Tozuka1*
1Osaka
University of Pharmaceutical Sciences; Laboratory of Formulation Design and Pharmaceutical
Technology; 4-10-1 Nasahara, Takatsuki, 569-1094 Osaka, JAPAN
288 - Development of novel crystalline forms of API via solid-state solvent exchange and form
transformation
Srividya Ramakrishnan, Y. Sesha Reddy, P. Subba Reddy, K. Sundaralakshmi, V. Jaganadha Rao,
Lalita Kanwar, P. Vishweshwar, Yogesh Dhage, Sumeet Patil, Sudarshan Mahapatra Dr. Reddy's
API Process Engineering, IPDO
Dr. Reddy’s Laboratories Ltd., Hyderabad, INDIA
Thu 12:00 - 13:00 Lunch
Thu 13:00 - 14:30 Coffee Break + Poster session B
Thu 14:30 - 15:50 PLENARY SESSION 4
Product Engineering
Invited : Wolfang Peukert
Friedrich-Alexander University Erlangen-Nuremberg
Innovative methods for particle formation, formulation and characterization
313 – Effect of synthesis conditions on hydrated calcium pyrophosphate crystals formation and
characteristics
Pierre Gras1, Kémie Ley-Ngardigal1,2, Sébastien Teychené2, Christian Rey1, Béatrice Biscans2,
Stéphanie Sarda3 and Christèle Combes1
1
Université de Toulouse, CIRIMAT, UMR 5085 INPT-CNRS-UPS, Toulouse, France
2
Université de Toulouse, Laboratoire de Génie Chimique, UMR 5503 INPT-CNRS-UPS, Toulouse, France.
Université de Toulouse, CIRIMAT, UMR 5085 INPT-CNRS-UPS, Université Paul Sabatier, Toulouse, France
3
252 – Evolution of single molecular chirality from achiral reactants in a crystal solution system
René R. E. Steendam1, Jorge M. M. Verkade1, Tim J. B. van Benthem1, Hugo Meekes1, Willem J. P.
van Enckevort1, Jan Raap2, Floris P. J. T. Rutjes1 and Elias Vlieg1
1
Radboud University Nijmegen; Institute for Molecules and Materials;
Radboud University Nijmegen, Toernooiveld 1, 6525 ED, Nijmegen, The Netherlands
2 Leiden University; Leiden Institute of Chemistry;
Leiden University, Einsteinweg 55, 2333 CC, Leiden The Netherlands
Thu 15:50 - 16:20 EFCE Award
Thu 16:20 - 16:50 Coffee Break
PARALLEL SESSIONS 4
Thu 16:50 - 18:30 Fundamentals of Crystallization Science
110 – Aggregation of growing crystals in suspension: Poiseuille flow crystalliser
M.J. Hounslow, K. Pitt
Department of Chemical & Biological Engineering, University of Sheffield;
Mappin Street, Sheffield, UK
108 – Continuous Crystallization and Polymorph Selectivity in the L-glutamic Acid System
T. C. Lai1, S. Ferguson1, L. Palmer2, B. L. Trout1 and A. S. Myerson1
1Massachusetts Institute of Technology ; 2University of Strathclyde
77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States
122 – The application of continuous plug flow reactor for the particle size control
Zhao, Yan; Hou, Guangyang; Power, Graham; Glennon, Brian
University College Dublin, Ireland
183 – Spherulitic Growth of L-Tryptophan
J. X. Yang 1, 2, Y. L. Wang1, 2, H. Wu1, 2, H. X. Hao*, 1, 2, B. H. Hou1, 2, Y. Bao1, 2, C. Xie1, 2, Z. Wang1, 2
1School
2The
of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China;
Co-Innovation Center of Chemistry and Chemical Engineering of Tianjin
166 – Investigation on the transition from gel to crystal of cefotaxime sodium
Gao, Zhenguo (1); Bao, Ying (1,2); Yin, Yongheng (1); Wang, Zhao (1); Hao, Hongxun (1); Yin, Qiuxiang
(1)
1: School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, P R China; 2:
Tianjin Key Laboratory for Modern Drug Delivery and High Efficiency, Tianjin University, Tianjin,
300072, P R China
Thu 16:50 - 18:30 Process Design, Scale-up and Downstream Processing
209 – The crystallization of desilication products in the Bayer process and its impact on hematite
solid/liquid separation properties
F. Jones1, A. Senaputra1, P. Fawell2, P. Smith2
1Curtin
2CSIRO
University; GPO Box U1987, Perth, Western Australia 6845, Australia
Process Science and Engineering, PO Box 7229, Karawara, Western Australia 6152, Australia
359 – Struvite precipitation with MgO as a precursor: Application to wastewater treatment
Pierre Stolzenburg1, Aurélie Capdevielle1, Sébastien Teychené 1, Béatrice Biscans1
1Université
de Toulouse; CNRS, INPT, UPS ; Laboratoire de Génie Chimique UMR 5503; 4, Allée Emile Monso,
F-31030 Toulouse, France
225 – Determination of nucleation and crystal growth rates of calcium carbonate during the
carbonation of a suspension of lime in a pilot batch reactor
M. Schnebelen1,2, M. Ricaud3, A. Jakob2, D. Sy2, H. Muhr1, E. Plasari1
1Université
de Lorraine, Laboratoire Réactions et Génie des Procédés ;
1 rue Grandville, BP 20451 54001 Nancy
2Solvay Spécialités France – Site de Salin de Giraud; Routes d’Arles, 13129 Salin de Giraud
3Université des Sciences et Techniques du Languedoc de Montpellier 2, Groupe Dynamique des Phases
Condensées; 2 Place Eugène Bataillon, 34095Montpellier Cedex 5
216 – Dissolution of activated serpentine and precipitation of magnesium carbonates for a flue gas
CO2 mineralization process
S. Hariharan, M. Werner, M. Mazzotti
Institute of Process Engineering, ETH Zurich, Sonneggstrasse 3, 8092 Zurich, Switzerland
310 Design and Optimization of MSMPR Crystallizers
Power, Graham; Hou, Guangyang; Zhao, Yan; Glennon, Brian
University College Dublin, Ireland
Thu 16:50 - 18:30 Product Engineering
286 – Improving surface charge and particle size in precipitation of métal sulphides
A. E .Lewis,; M. Nduna,
University of Cape Town, South Africa
257 Development, Analysis, and Validation of Novel Models for Continuous Stirred-Tank
Crystallizers Subject to Withdrawal Classification
Whelan, Ronan; Hou, Guangyang; Glennon, Brian
University College Dublin, Ireland
340 – Production and characterization of magnetic core nanoparticles for photocatalysis.
Y. Ruzmanova 1, M. Stoller1, G. Recine2, J.F. Hochepied3, D. Maury4, A. Chianese1
1University
of Rome «La Sapienza»; Department of Chemical Material Environment Engineering;
18 via Eudossiana, 00184 Rome ITALY
2LABOR s.r.l.; via G. Peroni 386, 00131 Rome ITALY
3ARMINES SA; Boulevard Saint Michel 60, 75272, Paris FRANCE
4Marion Technologies SA; Parc Technologique Delta Sud, 093040 Verniolle FRANCE
178 – Sugar Alcohols - Multifunctional Agents in the Freeze Casting Process of Foods
P.T.N. Nguyen, J. Ulrich
Martin-Luther-Universität Halle-Wittenberg, Zentrum für Ingenieurwissenschaften,
Verfahrenstechnik/TVT, D-06099 Halle, Germany
221 – Cocrystallization induced by compressed CO2 as antisolvent
P. Subra-Paternault1, C. Neurohr1, C. Harscoat1, S. Lecomte1, A-L. Revelli2, S. Laugier2 A.
Erriguible2, M. Marchivie3
1Université
de Bordeaux, CBMN UMR CNRS 5248, IPB, Allée Geoffroy St Hilaire, 33600 Pessac
de Bordeaux, IPB, I2M – TREFLE, 16 avenue Pey-Berland, 33607 Pessac, France
3Université Bordeaux Segalen, Pharmacochimie, CNRS FRE 3396, 33000 Bordeaux, France
2Université
Thu 19:30 Conference Dinner + Poster Prize
FRIDAY September 19th, 2014
PARALLEL SESSIONS 5
Fri 8:30 - 10:10 Fundamentals of Crystallization Science
170 – Influence of Agitation and Fluid Shear on Nucleation of m-Hydroxybenzoic Acid Polymorphs
J. Liu1, M. Svärd1,2 and Åke C. Rasmuson1,2
1Department
of Chemical Engineering and Technology, KTH Royal Institute of Technology ;
Teknikringen 42, SE-10044 Stockholm, SWEDEN
2Synthesis and Solid-State Pharmaceutical Centre, Materials and Surface Science Institute, University of
Limerick ;Castletroy, IRELAND
336 – Crystallization as a tool for Phosphorous Recovery from Wastewater: Kinetics and Uptake of
Contaminants
Ioannis Bountasa,b, Petros G.Koutsoukosa,b
a Department of Chemical Engineering, University of Patras, GR-26504 Patras, Greece
b Foundation of Research and Technology Hellas-Institute of Chemical Engineering and High-Temperature
Chemical Processes, Stadiou str., Platani Achaias, GR-26504 Patras, Greece
222 – Ice growth kinetics modeling of air-cooled layer crystallization from sulfate solutions
M. Hasan, M. Louhi-Kultanen
Department of Chemical Technology, Lappeenranta University of Technology,
P.O.Box 20,FI-53851 Lappeenranta, Finland
138 – Microinjection technique for generating batch reactions in picovolumes. Precipitation and
stabilization of metastable calcium carbonate phases
I. Rodríguez-Ruiz1, S. Veesler2, J. Gómez-Morales1, J. M. Delgado-López1,
O. Grauby2, Z. Hammadi2, N. Candoni2, J. M. García-Ruiz1
1Laboratorio
de Estudios Cristalográficos, IACT (CSIC-UGR).
Avda. de las Palmeras, 4. 18100 Armilla, Granada, Spain
2CINaM-CNRS, Aix-Marseille Université,
Campus de Luminy F-13288 Marseille, France.
134 – On the question of defects in natural silicon dioxide
L T. Lygina, V. Grevtsev, G. Suchкova, A. Mikhailov, A. Gordeev Alexander Alexandrovich; Gordeev,
FSUE CNIIgeolnerud
Zinin str., 4, 420097, Kazan,, Russian Federation
Fri 8:30 - 10:10 Process Design, Scale-up and Downstream Processing
182 – Ultrasound Precipitation of Manganese Carbonate: a Comparison between Low Frequency
Ultrasonic Sources
B. Gielen1,2, J. Jordens1,2, N. De Coker2, Tom Van Gerven1, Leen Braeken2
1KU
Leuven, Department of Chemical Engineering;
De Croylaan 46, 3001 Leuven BELGIUM
2 KU Leuven, Faculty of Industrial Engineering, Lab4U ;
Agoralaan building B box 8, 3590 Diepenbeek BELGIUM
203 – Computational investigation of the influence of the initial conditions on solid state
deracemization experiments
M. Iggland, M. Mazzotti
Institute of Process Engineering, ETH Zurich, Zurich, Switzerland
185 – Multistage Continuous MSMPR Crystallizer with Solid Recycle
Jicong Li, Bernhardt L. Trout, Allan S. Myerson1
1Novartis-MIT
Center for Continuos Manufacturing and Department of Chemical Engineering, Massachusetts
Institute of Technology;77 Massachusetts Avenue, E19-502, Cambridge, MA, 02139, USA
321 – Modelling, validation and optimisation of a lab and bench scale batch crystallization process
T. Koyama1, H. Ueda1, Y. Oguchi1, H. Mumtaz2 and S.Kashiwaya3
1Ajinomoto
Co. Inc., 1-1 Suzuki-cho Kawasaki-Ku, Kawasaki-Shi, Kanagawa 210-8681, JAPAN
System Enterprise Ltd, 6E, 26-28 Hammersmith Grove, London W6 7HA, UK
3PSE Japan, F-9 Yokohama Business Park, W. Tower, 11F, 134 Godo-cho, Hodogaya-ku, Yokohama 240-0005,
JAPAN
2Process
233 – Theoretical investigation of the Cu/ZnO methanol catalyst precursor preparation by the use
of a multicomponent population balance model
M. A. J. Hartig1, N. Jacobsen2, W. Peukert1
1Friedrich
Alexander-University Erlangen-Nuremberg, Department of Particle Technology; Cauerstr. 4,
91058 Erlangen GERMANY
2Clariant Produkte (Deutschland) GmbH, BU Catalysis & Energy, R&D Syngas Applications ; Waldheimer Str.
13, 83052 Bruckmühl GERMANY
Fri 8:30 - 10:10 Industrial Challenges
141 – Influence of seeding on concentration distribution within pastilles drop formed out of binary
melts
K. Wendt, S. Petersen, J. Ulrich
Martin-Luther-Universität Halle-Wittenberg, Zentrum für Ingenieurwissenschaften, Verfahrenstechnik/ TVT,
D-06099 Halle, Germany
220 – Supersaturation buildup in Confined Impinging Jet Mixers - A multi-scale coupling of CFD and
population balance
L. Metzger, M. Kind,
Karlsruhe Institute of Technology, Institute of Thermal Process Engineering
Kaiserstraße 12, 76131 Karlsruhe, GERMANY
323 – Utilization of Batch Experiments to Develop a Continuous Cooled Antisolvent Crystallization
Process
C. Polster1, C. Burcham1 and S.K. Bermingham2
1Eli
Lilly and Company, Small Molecule Design and Development, Indianapolis, UNITED STATES OF AMERICA
Systems Enterprise, Life Sciences Group, London, UNITED KINGDOM
2Process
9:30 – 10:10 Challenges in Industrial Crystallization: Round Table
Mei-yin Lee1, Robert Geertman2,Matthias Rauls3 and Peter Daudey4
1GSK, UK; 2DSM Chemical Technology R&D, Geleen, NETHERLANDS; 3BASF SE, GERMANY; 4Albemarle
Catalysts, Amsterdam, NETHERLANDS.
Fri 10:10 - 10:40 Coffee Break
Fri 10:40 - 12:40 PLENARY SESSION 5
Industrial Challenges
Christopher Burcham
Eli Lilly & Company
Continuous Crystallization in Pharmaceutical Manufacturing, an Industrial
Perspective
169 – Use of Continuous MSMPR Crystallization with Integrated Nanofiltration Membrane Recycle
for Enhanced Yield and Purity in API Crystallization
Steven Ferguson 1,2, Franziska Ortner 1,4, Justin Quon 1, Ludmila Peeva 3, Andrew Livingston 3,
Bernhardt L. Trout 1, and Allan S. Myerson 1
1
Novartis-MIT Center for Continuous Manufacturing & Department of Chemical Engineering, Massachusetts
Institute of Technology, 77 Massachusetts Avenue, 66-568, Cambridge 02139, United States.
2 Chemical Process Research & Development, Biogen Idec, 14 Cambridge Center, Cambridge, Massachusetts
02142, United States.
3
Department of Chemical Engineering, Imperial College London, London, Exhibition Road SW72AZ, UK.
4
Centre for Life and Food Sciences Weihenstephan, TU Munich, Munich, Germany.
151 – Control of particle size and scale-up of the agglomerative crystallisation process of an active
pharmaceutical ingredient
Sara Rossi1, Aditya Matharu1
1Product Development, GlaxoSmithKline Medicines Research Centre, Gunnels Wood road, Stevenage, UK SG1
2NY
326 –Structural modelling for the prediction of impurity rejection in pharmaceutical development
Marziano and K. Pencheva
Pfizer Worldwide Research & Development,
Ramsgate Road, Sandwich, Kent CT13 9NJ, United Kingdom
348 – Towards a more rigorous control of seeded batch crystallization
A.C.P.M. Backx2, X.J.A. Bombois3, P.J. Daudey1, M. Forgione3, R.M. Geertman4, P.M.J. van den Hof2,
S.S. Kadam3, H.J.A. Kramer3, J.A.W. Vissers4, P. Vonk4, G.M. Westhoff5
1Albemarle
Catalysts, [email protected], Amsterdam; 2TU Eindhoven; 3TU Delft; 4DSM Chemical
Technology R&D, Geleen; 5FrieslandCampina, Amersfoort, NETHERLANDS.
Fri 12:40 - 13:00 Closing
Fri 13:00 - 14:00 Lunch
Fri 14:00 Departure for Airbus visit