LE SYNDROME INFLAMMATOIRE INEXPLIQUE CHEZ L`ENFANT
Transcription
LE SYNDROME INFLAMMATOIRE INEXPLIQUE CHEZ L`ENFANT
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•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• "# ) -' "# ) # ! "&&" "!! !"# # 1 !" #$# 4%" "# #+ "!! !"# ' $ "#: ' # !' )3'#" # 53 # '% "# "# %'# " 5)3'#" .'# '- !' "# "# %'# '! + ."# = +'#"# # &!'%%' "# B " ! ,+ +# " +'#"# = "# ) !+ " ,!"#1 )" ." $ "# 5"&&" %)! * +"# "&&" # .'# % " • "# ) #) "&&" 1 ' * "# !' )3 !"# ')',!"# "# %+ ' " "# $ I "#1 &!'%%' "# ! 4 "%" ": ,!" "# D>1 6E 11 ' # " .+"# ' # !"# !!"# # $ ( * "# " " # % !" "# "!! !"# ' !' +) "# #" &!'%%' 3+% I "# 5)3+ " ' "# " <$%"# %)! * +"# ' )# " " %4 " ' # ' # " ' "# %'!' "# • "# 3+% I "# " !"# $ I "# = "# %+ ' " " # # " # )'# * "%" !" ) "("%)!"1 " ' "# 3+% I "# 5"( '< ": " # "!!"# # I+"# ' # !"# - ' %%+ ' "%" !"# #)+ &* "# #) ,!"# ') 4# ' " $ I "# 5 ) !$ .' + 81 !+' " + # "!! !' " " #$ 34#" A1 '!)3': )3 !" +- ' #1 !' D>16E "# %+ ' " # + & %+# •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•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• " ')) ! "( ! # & '." + * " ') " • -%" ' # - & ' ." ) " +' • -%" ' ) ) "- + " ! • #'-" &' !" " ") • 2 % ++ +% " ' -%" "1 !' " %' "(" " ) !$ "= "# #$ %"# &!'%%' ' "%" '!" " &(' '!"1 !"# # I"# " &" " +& 1 !' ')' $)" !" &' ,!" &!'%%' $ #" )" ' + "# &+ " " " ! / 3 * "# '))' ' ##" " / O- ; % ' &" " -' #%" # +) #" '!" " &(' ! " +% " ' "1 " " '& '# " "##'$" " ' -%" " D>1 81 >P1 6AE $ #" = 1 "&&" " B " ! +" / ! ' 3% ,!+ # " ' #%": " $ I "# 5&' " " ' ' ' >: # • $)" )!'* " 3+! '!"# " !" 3+% I "# " ' "# ! - +"# )3 !"#1 ! + '( " # " )' & # " " #'-" D>1 A1 9E + !+' "# 3"% ' #" ,!" " ' +% " ')' " 3$)" !" &&+ " "!!" ' &!'%%' 3$) # + +% " " • / !' +% - '%%" # %)" #" " " &!'%%' • " &!'%%' •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• ," ' + "! = 71>A%%1 " • ") ' +'! #' " ." " - ' $+ / ! ' + 1 '." " " >19%! - J " / !' %+ 3 B " 67 %1 #' - " - ! + " " " #"# = '%4 " " " 61AAW ; ! +" ) # #+ 3+ !' " ! ') " % +!' -" %%+ ' ." + # " !"# 3+%' "# #" &' # " +'! #' ." " #" " +. ' -' •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δ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sensitivity 1 0,9 0,8 0,7 0,6 0,5 0,4 0,3 0,2 0,1 0 # "# %' * " # "! "%)# DA9E &!'%%' " & PCT CRP ROC curves IL6 1-specificity 0 0,1 0,2 0,3 0,4 0,5 0,6 0,7 0,8 0,9 1 Bacterial vs viral infections in 360 children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• "# 3+% I "# " !"# $ I "# = ' %)!"( + " ! %)! ' "# " ' L .'!" M # '." !" 4# "!' ." "# $ I "# ' # !' +) # + ") " #" # %"%, ' ' "# )" %" %%" +% ) " "! ) &!'%%' " 0 -" "## # "" " !" &!'%%' " D>1 6E •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• ' )! )' 3 • "# * "# ' ## !"# "# &" &" " " #"# = &" )" ." &" &!'%%' # ' - ]# " B " "#) )' ! " ,' + " #',!"# #$ "#1 # ,' - ]# %" &!'%%' " %' # # . '!"# " )' '# ' "# # ,' + " "# = ," # )# " ! #"1 %'!' " "# - &&"# 3' 1 !' &4. " $)3 Y " • "# &" # . 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• ! #" # &!'%%' # - "# , ! - * "# " +' %+ ' ." + " +% " &!'%%' o $)" !" $ #" o $)" )!'* " #" )3 ) +#" ." " & # " !" #$ #* " .' "# ' ',# " #" #$ %" +!+ +" "= " 3$) 3 %" % "# = +/ $' " " ' -%" ' "# & ' # '!)3' >" ." "%" " 3$) '!, % +% " "= %" "# " &' # '#$%) %' * "# &' " ." # ." +!".+" "# ) '!)3' 6 -! , ! "# '## ' "%" ' & % !" #' - o 6 @ + " " "= " . "##" " #+ %" ' !+ )" ." &!'%%' " )" + ' " 3" 3" # - " #" " " !"# "('%" # %'! "# , ! - * "# ' # !' " " B " ."!!" D66E 39 &! " 3"< " "# %)!+%" ' "# / +'! #" # !+"# " +# ! & #" #) # ' +" ." / " ' " %' &"# ' " @ +%' 3" '- " # ' &" ! # # )) #" • # * "= # - " #$ "()! * " ' " !" #$ +. ! • %" ' #+%" &!'%%' " '" ) &" )' & # " %'!' " " #"%,!" "#) +'! #' "('%" # "# ! * "# .' + "## " , ! - * "# -' • " ") #" # - " #" " ! +# ! )' )'# )' " # !' ' " * •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• # 5%+ " " * B" % ' +'! #+" / !' 3 # '% ) "# / ' "# / +)+ +" % " # "# " " :1 +0/ "%" "+ ' # #$ ' " " # "# "()+ " " &+"# 3"< !" # ' ## " %" ## " %+ '! )" %" !"# " !"# 3+ ')" %+ ' "%" 3$)" #" # , ! + ' #& # ' ( ' + " " "# %'!' "# " " #" # " " ." # !' &! )'# & # ' 1 -"# "# " ' "1 +. ! ' "#) 3', " ' #" %+ ' +"1 + # #". '-" #" ' ) ' * + D>P1 661 6A1 @8E 41 * "# ' + " "!!": #',!" * "#1 β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•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• %4 "1 ' " 3" 3" " ')' % #" " &' + / #" !"." "1 !' +#3', !!'-" #) ' +" "& # #)' . #'-" ! !' ',!" ' # !" % ' .'!" ) " #+% ! - " ) ) " / !' "## # &" !"# # - "# " ( ! "()' # &# ! ' # !" , '# %'!- + # "! % " "! )" " + " " !' #+% ! - " & '!" = " ! "('%" " ! "('%" ."%" 1 !" " " " #" "# %'0" " '! #+# " #' 3' # !"# "##' # ."%" # " ' '!- * " / #" %" ' # !" * " !' " )+ # ! " ' " / # '## " !' " '- !" ", # )" "# )++ " %'-" " • "('%" )+ )3+ * "# "# ' "# "('%" ! -' -! * " ' "# / ) + #" !" !' " 3" 3" ' + )' 3 "# ' ' + # * "# = ' !!"1 # +-"1 %, "1 #" # , ! + " % , ! + • , "('%" #+ ' " " %B%" % )" 3+" " %"1 ! !' "= ! + #)" '.' 1 !' ) "## • ' )'!)' ' +1 • ' "< + " !' " " !' & " 3" 3" ) # " ", " 3" 3" " " - + #H H "# %"%, "#1 &! +" ' 3# " 3'* " +) " #" " !' "# %'##"# % # "# F "#1 !' )'!)' " !' %' 3" / !' " !' )'!)' " #"-%" ' "1 !' % , ! + "# ' " !' "#1 !' ) "## "# # ! -1 "# %' # / !' " 3" 3" #" %1 !" # # +" " % # !' " #"-%" ' " 5 '%%" 1 "# "# "# %"%, "#: • "('%" " %' ! - * " !' " 3" 3" " ! ." !' ) -%" ' -!"#1 1 "# • !+# ' "# )' %"# ')3 "# , #$ ' +"#1 "# %' #1 3"."! 5'! )+ "1 " 3" 3" + "##" / ! '))' " % - ')3 #%"1 "# +!' - " '# "# - #1 )' ' #H :1 1 # " '#3# %" " '$ ' - +'!"#1 "# " !# 5!+# -+ ' (1 1 ' +#1 ,!" " !' "#1 ! "('%" # " .'# !' "# "1 &' ( 2 ": ' ( # ' '!"# 44 ! +' # ' +"#1 " • ('%" ', • ('%" N 1 % '! = 3+)' %+-'! "1 #)!+ ' .'# % "# ) • ('%" • '!)' • ('%" •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• %" )$ '% '!1 +&!"("# # " = 3+! "1 !' - " +)') !!+"1 )3' $ - "1 # %' ' . "##" " #+ %" ' " ##"%" !# )+ )3+ * "# " % " ! "('%" &!'%%' '* "1 '## '! #+"H " !' 3$ Y " • • &&!" ' %+-'! "1 #" # , ! + ! )!'#%' * "# " "* M ! !"# )! # 45 "# ,"' / !"# "* " !' ! #+"# +' ." ) )! # )+"# # + " 5 # !" :1 ' - +' "# ." !' ) )" & %' " ) "# ! # + "5 + " "# " ! &' " !" "# %" !!" &" := '- # # ,' + " " )+ # %' * " "# 3' "#1 )' & # @77 / 877 %-;! ' &!'%%' " + * " #$ %" # , ! - * "# `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• " '! B " %' * " " " +% %' * " " #" # , ! + " 8 / >7 -;! D66E * ' +% - " ! ' ,' + " %)!+%" %)!+%" +% "1 " .'!" " " " ! +' ) &" &" " ( " # * " ! )" %" . '!" ' .'!" " DAAE = "# 4# 3', #* " !" #$ !" '-" - '%%" ; % !! ! %)!+%" ! +!+.' ." #"1 ! % +-'!"%" &" #$# 4%" " " )" %" " / >7 / 67 ' " #$# 4%" &!'%%' 3$) * &+ " " "# %%" "= ! " &' 1 %' * " &&+ " '# # " @G / 8A -;! "# '!)3' 6 -! , ! "# + B ! % +1 " %'!" .' " " ') • !'## * " "# "# " %'!" .' " " ,#" .+" ' '47 # %)! * + ' # !' "!!" "# & ' # @ " %" &!'%%' " #' #" ." +' 8 " %)'- " '##"< ) + #+%" " += " # &&#' "3 # +& " 3+)' " #$ 34#" "!! !' " #+.4 "1 ! # '- +)3 )' 3 " -! %+ !' " ) # # ") # ! ) # + $ 3+%' " ( $)" #") 71@8 -;! ) • - # ' " ,' + " " 71GA / >18 -;! ) ") ! &!'%%' &" " #" " # ,' - ] @" " 71>7 / B " ,#" .+"# ' # -+" = " / ' -%" " " - " 3 %, - " ) !$ " " ' ')' " + % '!" $ ' " '." " &(' * " " / $ #" !+ #" / " &" ' " " )3 !" * )" " " / " &!'%%' %)!+%" ' "# . " #" -' " % " ( " " "# " # !+ " "('%" "()! * +1 " ' ! * " %)!" 1 !" %, " "('%" # B " +'! #+# = S !' , ! - * " = !"# #+ ! - "# = !' " 3" 3" " )' 3 ! - " - R '!" = R 1 SR1 - S' + " #'!% ." # ! -* " = ') 4# - " ) ! &+ ' ."1 " %'!' " "" " " ,: , !' + •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•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a)' 3 '( " "!' )!" %, " " '#: '! 56: 5>: '!' " )' 3 " 3 !' " 5>: #+ * " 5>:1 _ 5>:1 %+-'! " 56: %'!' " #+ * " 5>: 5>: ' #* "!" " 6;>G "# ##" #"# 5>: %) "## # 5>: - & %"# $%)3 %" _> 5>: 5 J "1 ' 3 #: 5>: $ 3 !+ $# " 5@: R+# !" , ! ' " / )' _ 5@: #" " " 59: _ 5>:1 #' # 58: a 3 - ')3 " , % '!" '- # 5>: " %' %$ # " " 5A: !' ' '! 58:1 _ 5>:1 )' 3 "# 5@: # >G;8@ / (#' I " 5>: +)' ## " 5>: + &" ++ 5>:1 )$+! 56: '!' " #+ * " "!!" 5>: 5>:1 !" #)!+ * " 5>: '# !"%' 5>: T" _ 5@:1 5>: T 56: $%)3 %" _> 5>: '# !"%' 5>: +. $#%"# _ 5G: ' " 5 ": # 5G: a 3 - ')3 " ' !' ' >A;A7 '* " + ' $ ' _ 5G:1 " 5>8: 5@: %'!' " #+ * " " 56: 5>: _ 5>:1 = ' 3# + - ')3 " Q $' " Q .' " Q _ = %'!' " " _'^'#'I Q T = ' 3 " 0 .+ !" = )+ 8== ',!"' 8 ' + " %, " " ' = #$ )' 3 * " Q " #" Q " "# ' %" = %'! "# "# ' ' .' T 5>: !$%)3 # + %$+! " % ! & '!" = 3+)' %+-'! " Q + 3 - ')3 "# D66E 51 T 5@:1 = #)!+ - ')3 "# " %+-'! " "# •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• ' %% ." %'!" 3"< "# '# " %'!' " " I'^'#'I • "('%" " " &' " " ) # "# )'# %%+ ' "%" '." !"# !"# &&+ " # !', '#1 " + ' &' "# " , ! - * "1 3 % * " D6AE ' + " "# , !' # = #"! " # " <$%" " )" ." # " %'!' " " !! D6>E " 3" 3" " ' " " #"-%" !"# # - "# '))"! -"# ." 3' " " ,'##"1 "!' - ' # - B!"1 !'.'-" '!.+ !' "1 " # " ! - "# "# #$ &!'%%' - " !$%)3 $ ' " " .+ " •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• " B " "# + &" )! # # &" " " "# #$ "!4." " #"# " * !' -"%" ': !"# &" , '!" '!" #$ )" %" &!'%%' ,+": " ! '))' ) ## , ! +# %% '- # )) "## " 5)' "("%)!" ' -%" ' " &4. " ) ! # * "# = !' # ## -+" )" ." #" ' " !' 0 #* " !' )" %" " / " " & # " &&+ " # "- + ')) + +" )' !" ' ( "# !$%)3 $ "# 8 5 ',!"' A: D6A1 @P1 A6E 55 %, " ',# ! '!% " !$%)3 $ "# 8 5>7P; : b 877 b677 b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•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• "# &" * ' !" -' 0" " &' ' '$' )'# )" " " %" " &' " " D@PE " #$# +% * " = " '! + ' " #)!+ " ! +' %+-'! "1 ' %'!' " ' " &!'%%' " 3"< +-'!"%" " "# )' & # ,"' !" ) % = ! 3$)" -'%%'-! , ! +% " $ "# # )' & # && !" " !' #+ ! - " " +-'!"%" %'! " * " !' #)!+ %+-'! " # D6A1 @A1 8PE #%" = )" & +% " )' !' " ! &' 3"< ! " &' / +. * " " ! + ' -+ + '! ! "('%" " " 3$)" -'%%'-! , ! +% " %'0" #+0 )'! # " " &4. "1 )' '# " ' # !' % "!!" "# )' & # # ' -+ +" < 3"< !" - ' " )'! ) ! ' &!'%%' " 3+)' %+-'! " " # # %%+ ' "%" &' " +&' # 0' " " "# )' '# ' " !'## * " '## #+0 ' " 3" 3" 0 &" 3"< !"* "! !" #$ '! * " # 4" " ! " ' +% " 3+% !$ * " " " " &' ' !" ',!"' '%' - ##"%" 1 )+ "1 )+ ' #" . # + '!" = "# ! "("%)!" $)" -+ + '!1 )' 3 " # ' "# " # )' '# ' "# = ' !" #3%' 'K , " !' ' #!" : # #'" + . $'-" + " !" # " )'! " &4. " ) ! %%+ L )'! # #' - '- * +-' & D@A1 @PE 60 #%" ! &' " < " ".' -+" '." #)!+ #%" . # + '! +. ! 1 ! "('%" ' # " +% " +' &+, ! %+-'! " " '! + ' &M " '- +)+ " ' ! )" # # "# &' )' ." B " ,: !"# &" ' .'!" ')) ! #! '! #' "1 !"# # - "# ! "%)# ,#" .' '- ! J-" ! * "# 3', &!'%%' "%,!+ &" " '))' # ) #' &'% !!" # ') 4# - " ' " !' "%' " # + '!": D@AE "# #$# +% * "# # % " 1 )' ! 4 "%" 3"< !" !! %" " I'^'#'I = # "# " %%+ ' "%" '.' % ' (1 " ( * " ! " &' %" " I'^'#'I " !' %'!' " " " #$ " ! # &!# ' "1 " ( '&&" = !" #$ ': !"# %" !!" ' ', )' * " "# #$%) F%"# * "# & ' (1 ) +#" # 8 6 !"# %'!' "# " &' " 1 # %'-" " 5', 4# )" '! #+"# = " !' %'!' " " I'^'#'I +. * + 3"< " A ' #: ".' !" 0" "- "!# 5 ',!"' 9 G:= 61 "# " "( ! # ."%" " " &' )"%" " 5O7U "# * "!* "# 0 ! '# # # * "1 ! ." " "# # - "# &4. " #' # + ! -" ") # # *0 0 % " ' )! # 5PAU: . " , !' + '!" 5OOU: & ' , )3' $ -+"# = !4. "# #4 3"#1 -" " &## +" 5P7U: !' - " & '%, #+" 5GGU: -" , '!" " )3' $ -+" 5P7U: % $%) F%"# ) && #" " !' % * " #" & ' )' ( # "# "( +% +# = -" " !' ) %%" "# %' # " " !' )!' " "# ) " # 5)3'#" '!" 5OOU: N 4%" + 5G9U: "#* '%' - # 5)+ " !' ) !)" "# " " .'!"# " ": 5P8U: + ) ) !$% )3" 5P6U: %+&' "# -' -! #' # # )) ' 5GAU: ' " " ' %$ ' # " . ' ( '* "1 " )' " " )+ ' !" " ' 3+" ' 3 '!- "# ) + % ' 3 "# " " !" & ' !" $ # , ! - * "# = $ #" # 4 " ' +% " "# #$%) F%"# ' +!+ ' " !' R 1 +!+.' "# '!)3'6 -! , ! "#1 3$)" )!'* " %' &"# ' %+ 4" "# ',!"' 9 = ) " )'!"# %' &"# ' 62 # ) # ." #" '# "!!"# = - " '#") * " # " !+-4 " +!+.' ' #'% '#"#1 3$ 3 !+ $# " # " !' %'!' " " I'^'#'I D8AE " &4. " )! # " A 0 " 0 "' " # PAU . " , !' + '!" ", OOU )3' $ -+" = 3+! " %' P7U " GAU 3' $ - " P7U !"# "( +% +# = a $ 34%" )'!% )!' ' " OAU c 4%" GAU "#* '%' "+ ) ' + ) !$% "# - #; " !# P8U )3" P6U )' 3 "# " . '!"# )! # 4 "# = #$ %" $) * "1 b "> A % " '%4 " #' # GAU # )) ' 5A;9 ',!"' G = "# 4 "# '- d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`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"# 85 +"# " ! " -' "1 " ! "('%" ! * " " "# "('%" # %)!+%" ' "# ++ ' '!$#+# " +!' ' % %" " !' &4. " " !" ' "%" '- +) " ."1 ! '# 1 #* " !" # " '- "" " !" # +' +, +' 86 !" %, " " 0 " !' &4. " " ! "# + " ' " #' " !" +, ' @ "# ,#" .' •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e e : + " ! $ "# O9777;%%f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• '# X6 = ## " &!!" J-+" " # ' # " # % # ',!"#1 3 #) '! #+ !" >>;7O;6778 ) +. ! ' > % # '.' > % " "% '))' # 3 #) '! #' " * "!* "# 0 #$ '." # '.' ") +#" + ' # !" ',!"' >6 = 91 ' # ' + + " # )' 3 ! - * "# %" &+, !"1 " ' + , !' &' 3 && + / @OX )' 3 " !' + / )! # " " . '!" " # ") #"#1 "# , !' # +# ! ' # = , &!'%%' P18-; ! 53$) " g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•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h@ RC - @6i - >7977;%%@ CS &!'%%' 88i " $% A6i R - 8A ;PO - AP1O; 961@; O@1A%-;! %% ! -* " &" " ( - V - "# - S ' " - ')3 " " ) ' -' S - ')3 " % %"%, " # )+ " # )+ " " -' - +-' & - +-' & - +-' & - +-' & - %'!" - %'!" +3 %"%, " %'!" 3" + 3 - ')3 " ', ! -* " +-' & 3" + 3 - ')3 " ' - % '!" %'!" " !' ' ' " " -' 3" / 8 %% #' # '%) ' )' '!!+! #%" 5&- ">6: ' "# S !' )3 '!% %'! - 3$)" '!)3' 6 -! , ! "# / 6@18-;! ',!"' >@ = , !' # %)!+%" ' "# " ! " &' 95 !%'3 = - " >6 = + 3 - ')3 " ' '* " " % " 3$)" "6 +& -" 96 % " "# )' ' !' # ' " !' +" ' " ".' ' !' ) +#" " " ' " !' " ) ,',!" +. ! ' &!'%%' ++ % # # ! %' "1 !" # '- #)+- # / " ' # " !' %'!' " #" ' )" ' " '## +" / "( " &+, !" " &!'%%' * "1 , ! - * " " + 3 - ')3 * " " ' " " _'^'#'I & " '." " "!' # )' #% # 97 " " " ' " #$ +. * + " ! " &' 4# , #" " %" ' " +. ! " A%-;I-;0' + + • '# X8 = S !'! -' [ " " ( ' # " ( % # #' # ' + + " 3 #) '! #+ ) " &4. " ' ! / +" )' " &4. " + "## " "('%" ! "' " ',!"' - * " "# #' # )' >8 # " +, +# %" !"# , !' # ',!"#1 " #' #$%) %' ! - " "% / 3'* " & # "# ' !' )' 3 ! - * "# " )$ + * "# + +'! #+# 3"< S !'! " * ++ # #+" # %' ( !' # !"# >A 0 ." !!' #/ ! +. ! " " ! * "1 , ! - * " " + 3 - ')3 * " ' + + ) + % # ' + + %' * +" )' " +# ! ! 98 #) ' +" ') 4# #% # " , !' # +# ! ' # = &!'%%' " , - RC - A8h@ - >9 )- - >7777;%%@ - 9P6777;%%@ - >67%% CS R O1O-; ! G8%-;! %% ! -* " - - +-' & - - +-' & - - +-' & - +-' & - +-' & - +-' ." - +-' ." - +-' ."# - %'!" - %'!" - %'!" - %'! - - &" " ( S - " 3" 3" - + ! - "# "# 3+)' ' ' ! -* " S_ - ')3 " " ) +3 % " + 3 - ')3 " ', - "# S " S !' % '!" )3 '!% - 3$)" '!)3' 6 -! , ! "# / >71P-;! - ' "# - %'! ) + )' '# ! - " "# #"!!"# %'!" " " 68 3 %) " # %'!" , !' 3+)' * " %'! %'! ',!"' >8 = , !' # %)!+%" ' "# " ! " &' 99 S !'! • '# XA = 3 '& -' [ " >@ ' # ' + + " # )' 3 ! - * "# " ."' # ',!"#1 ) +#" ' + % * " % $" 1 #' # ") # % # 3 && +" - "('%" " , !' ! +)+ * " / ! ' % ## & +'! #+ "# + ' #' # )' !' +# ") +#" + )' !" ',!"' >A = 100 " &4. " , !' # +# ! ' # = &!'%%' , - RC - OGh@ - @91@i - 6P77;%%@ CS " >71>-; ! 98i $% @8i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•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e e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j '# XG = %' " 56: &!!" ',!"# - " " ( ' # #) '! #+" !" >@;7P;7A ) "('%" / ! ' % ## " , !' +'! #+ "# ( % #1 #' # ' + + " # )' 3 ! - * "# &4. " ") # A 0 + ' #' # )' !' +# +# %+ ' # !" ',!"' >G = 107 # +# ! ' # , !' # = , O1@-; ! 5e e : APG777;%%@ &!'%%' CS " >O777;%%@ $% + ! - A9i - 87i $ "# >A777;%%@ - >98%-;! R %% ! -* " P7;>6O - - +-' & - - +-' & - - - ' "( V '!" #" S &" - +-' & - +-' & " ( %'!" #+ ! - "# " " - ')3 " " ) + 3 - ')3 " ', ! -* " +-' ."# 3!'%$ ' I" # #" ' ' >G7 +3 % - %'!" % '!" %'!" " +)' )+ ' 3"%" * "% 61P 8%% 5 &- ">8 : S !' %+ ' "# )3 '!% - !! - '%%" , !' 3+)' * " +" %'! %'! 718A-;! -!$ +% " ',!"' >G = , !' # %'! %)!+%" ' "# " ! 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RC - 9@h@ @OA777;%%@ 67777;%%@ CS &!'%%' " $% - AAi - 8@i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` !' +'! #' !' " " !' ) +#" " " S_ * " % # " " &' -' "# ' + &" ," !" #" ' + + ) #+ 578;7A;7A: " ;8 +, ' "%" 1 ! "('%" )' 3 "# '( !!' "# %'!" 113 " A1A %% " ! * " '%4 " ." ' " - " >A = ! +. ! " !' ," 3" % * " 114 %'!' " !'" " 6: +# ! 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